Increased Th17 cells and interleukin-17 contribute to immune activation and disease aggravation in patients with chronic hepatitis B virus infection.

abstract：:Abnormal activation of the transcriptional factor STAT3 (signal transducer and activator of transcription 3) was recently associated with Alzheimer Disease (AD). STAT3 phosphorylation is critical for cytokine secretion linked to neuroinflammation. Moreover, STAT3 may act as a transcriptional regulator of BACE1 (β-APP ...

journal_title：Immunology letters

authors： Millot P,San C,Bennana E,Porte B,Vignal N,Hugon J,Paquet C,Hosten B,Mouton-Liger F

更新日期：2020-12-01 00:00:00

abstract：:Studies on natural cytotoxicity of peripheral blood monocytes were conducted in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis etiopathogenically linked to viral hepatitis B, and in asymptomatic carriers of HBs antigen. In the majority of cases of viral hepatitis in the acute stage o...

journal_title：Immunology letters

authors： Kiczka W,Szkaradkiewicz A,Flieger J

更新日期：1985-01-01 00:00:00

abstract：:We have studied the mechanisms involved in the activation or suppression of the immune response by the tumor cells, which is also dependent on the site of tumor transplantation. AK-5 tumor cells when transplanted s.c. activated peritoneal macrophages through the induction of different cytokines, whereas tumor cells wh...

journal_title：Immunology letters

authors： Mitra R,Bhaumik S,Khar A

更新日期：2002-07-03 00:00:00

abstract：:In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acut...

journal_title：Immunology letters

authors： Caprara GV,Nisini R,Castellani V,Vittorio P,Alessandri G,Vincenzo Z,Claudia F,Valentina G,Andrea PD,Biondo MI,Milanetti F,Salerno G,Vincenzo V,Mario P,Aniballi E,Simonetta S,Angela S,D'Amelio R

更新日期：2017-08-01 00:00:00

abstract：:Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD2...

journal_title：Immunology letters

authors： Bjørgo E,Taskén K

更新日期：2010-03-10 00:00:00

abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...

journal_title：Immunology letters

authors： Dubs MC,Altschuh D,Van Regenmortel MH

更新日期：1992-01-01 00:00:00

abstract：:Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...

journal_title：Immunology letters

authors： Demopoulos CA,Tsabikakis GE,Kapoulas VM

更新日期：1981-08-01 00:00:00

abstract：:The Nramp1 gene was originally described as Ity/Lsh/Bcg, a single gene controlling resistance and susceptibility of inbred mice to a range of intramacrophage pathogens. Functional studies demonstrated that Ity/Lsh/Bcg had multiple pleiotropic effects on macrophage activation pathways, broadening interest in the gene t...

journal_title：Immunology letters

authors： Blackwell JM,Searle S

更新日期：1999-01-01 00:00:00

abstract：:The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhib...

journal_title：Immunology letters

authors： Fábry Z,Erdei A,Gergely J

更新日期：1983-06-01 00:00:00

abstract：:The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytomet...

journal_title：Immunology letters

authors： Schmidt C,Burman K,Moss DJ,Ryan J,Burrows SR,Misko IS

更新日期：1989-12-01 00:00:00

abstract：:Four murine monoclonal antibodies (mAbs) showing similar reactivity with a cell-wall extract and mannan preparation obtained from Candida albicans were examined for epitope specificity. An enzyme-linked immunosorbent assay (ELISA) was used to determine total mAb binding to extracted cell-wall antigen when each mAb was...

journal_title：Immunology letters

authors： Chaffin WL,Morrow KJ Jr

更新日期：1989-07-01 00:00:00

abstract：:It is widely known that mast cells and cytokine TNF-alpha are both involved in inflammatory reactions. Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. The experiments were performed in vitro on mast cells isolated from tissues by enzymatic dispe...

journal_title：Immunology letters

authors： Brzezińska-Błaszczyk E,Pietrzak A

更新日期：1997-12-01 00:00:00

abstract：:Natural levels of goat antiphosphorylethanolamine (anti-PE) antibodies decreased after injection of purified human C-reactive protein (CRP). The concentration of anti-CRP antibodies followed a continuous increment from non-detectable levels to a plateau at 80 days after first injection. ...

journal_title：Immunology letters

authors： Coll JM

更新日期：1988-05-01 00:00:00

abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...

journal_title：Immunology letters

authors： Pappalardo E,Zingale LC,Cicardi M

更新日期：2003-05-01 00:00:00

abstract：:Monoclonal antibodies (mAb) reacting with native (TA5, TB12) and denatured (T33, T35) plant toxin mistletoe lectin I (MLI) from Viscum album have been obtained. The interaction between mAbs and native toxin with ML isoforms (MLII, MLIII) has been investigated. An immunological cross-reaction has been shown to take pla...

journal_title：Immunology letters

authors： Tonevitsky AG,Rakhmanova VA,Agapov II,Shamshiev AT,Usacheva EA,Prokoph'ev SA,Denisenko ON,Alekseev YuO,Pfueller U

更新日期：1995-01-01 00:00:00

abstract：:Even though IgA is considered to play an important role in immunity, surprisingly little is known about the presence of IgA Fc receptor (Fc alpha R)-expressing effector cells in tissues. Difficulties in obtaining human tissue macrophages, led us to study peritoneal macrophages in a human Fc alpha RI transgenic (Tg) mo...

journal_title：Immunology letters

authors： van Egmond M,Hanneke van Vuuren AJ,van de Winkel JG

更新日期：1999-05-03 00:00:00

abstract：:The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...

journal_title：Immunology letters

authors： Stanton T,Maynard M

更新日期：1984-01-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifaceted hematopoietic cytokine and the culture of mouse bone marrow with GM-CSF produces a variety of myeloid cells including granulocytes, macrophages, and dendritic cells. In the present study, we cultured mouse splenocytes with GM-CSF and examined ...

journal_title：Immunology letters

authors： Ryu SH,Na HY,Sohn M,Han SM,Choi W,In H,Hong S,Jeon H,Seo JY,Ahn J,Park CG

更新日期：2016-05-01 00:00:00

abstract：:Whilst many physiological functions of nitric oxide (NO) have been revealed so far, recent evidence proposes an essential role for NO in T lymphocyte activation and signal transduction. NO acts as a second messenger, activating soluble guanyl cyclase and participating in signal transduction pathways involving cyclic G...

journal_title：Immunology letters

authors： Nagy G,Clark JM,Buzás EI,Gorman CL,Cope AP

更新日期：2007-07-31 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen presenting cells, well equipped to initiate an immune response. For effective induction of an immune response, DC should migrate from the periphery to the lymph node to present the antigen to T lymphocytes. Currently, tumor-antigen loaded DCs are used in clinical vaccinat...

journal_title：Immunology letters

authors： Eggert AA,van der Voort R,Torensma R,Moulin V,Boerman OC,Oyen WJ,Punt CJ,Diepstra H,de Boer AJ,Figdor CG,Adema GJ

更新日期：2003-10-09 00:00:00

abstract：:Heat-sensitive serum masking cofactor(s) of antiphospholipid antibody (aPL) in normal human sera (NHS) are specifically inactivated at 56 degrees C. The degree of binding in ELISA by unmasked aPL in NHS was equivalent to that in non-heated, aPL-reactive autoimmune SLE sera. Previously "negative" SLE sera also reacted ...

journal_title：Immunology letters

authors： Cheng HM,Wong KK

更新日期：1990-01-01 00:00:00

abstract：:House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...

journal_title：Immunology letters

authors： Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota S

更新日期：2003-01-02 00:00:00

abstract：:The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to invest...

journal_title：Immunology letters

authors： Naouali A,Kaabachi W,Tizaoui K,Amor AB,Hamzaoui A,Hamzaoui K

更新日期：2015-03-01 00:00:00

abstract：:Although several components of the microbial wall of gram-positive bacteria and fungi possess immunostimulatory properties, their pathogenetic role remains incompletely evaluated. The purpose of this study was to assess the basic immune status of patients susceptible to infections and their capability for cytokine pro...

journal_title：Immunology letters

authors： Tsigou E,Aloizos S,Myrianthefs P,Gourgiotis S,Tsakris A,Baltopoulos G

更新日期：2014-05-01 00:00:00

abstract：:In human tumors of neuroectodermal origin cell surface expression of individual gangliosides is either increased or decreased relative to comparable normal cells. We have previously shown that gangliosides shed from melanoma cells can immunomodulate T cell activity. Monocytes/macrophages (m/m) are known to play an imp...

journal_title：Immunology letters

authors： Hoon DS,Jung T,Naungayan J,Cochran AJ,Morton DL,McBride WH

更新日期：1989-03-01 00:00:00

abstract：:While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...

journal_title：Immunology letters

authors： Wu P,Hyodoh F,Hatayama T,Sakaguchi H,Hatada S,Miura Y,Takata-Tomokuni A,Katsuyama H,Otsuki T

更新日期：2005-04-15 00:00:00

abstract：:The observation that protective immunity induced by immunization with radiation attenuated Plasmodium berghei and Plasmodium yoelii sporozoites is dependent on CD8+ T lymphocytes in some strains of mice led us to speculate that immunization with sporozoites induces cytotoxic T lymphocytes (CTL) that recognize malaria ...

journal_title：Immunology letters

authors： Hoffman SL,Weiss W,Mellouk S,Sedegah M

更新日期：1990-08-01 00:00:00

abstract：:It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes...

journal_title：Immunology letters

authors： Comerford I,Nibbs RJ

更新日期：2005-01-31 00:00:00

abstract：:To elucidate the role of macrophage migration inhibitory factor (MIF) in ocular inflammation, we examined the localization of MIF in the normal anterior uveal tract of rats. Immunohistochemistry using an anti-MIF antibody revealed that MIF was present in non-pigment epithelial cells of the ciliary body and the epithel...

journal_title：Immunology letters

authors： Matsuda A,Kotake S,Tagawa Y,Matsuda H,Nishihira J

更新日期：1996-10-01 00:00:00

abstract：:Pulmonary intraparenchymal leukocytes were purified from normal mice. By flow cytometry, 20-30% of the lymphocytes were positive for the expression of Mac1, a cell-surface antigen largely restricted to macrophages, neutrophils and natural killer (NK) cells. Sorted Mac1+ lung lymphocytes were large and had abundant cyt...

journal_title：Immunology letters

authors： Kawakami K,Teruya K,Tohyama M,Kudeken N,Yonamine Y,Saito A

更新日期：1995-05-01 00:00:00