Abstract:
:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Martínez-Pomares L,Gordon Sdoi
10.1016/s0165-2478(98)00117-5subject
Has Abstractpub_date
1999-01-01 00:00:00pages
9-13issue
1-2eissn
0165-2478issn
1879-0542pii
S0165-2478(98)00117-5journal_volume
65pub_type
杂志文章abstract::Many types of cells in the immune system have been found to produce nitric oxide (NO), which performs multiplex functions. However, in myelin basic protein peptide 68-86 (MBP 68-86)-induced experimental autoimmune encephalomyelitis (EAE) in Lewis rats, we found that elevated NO production was generated from spleen cel...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00154-1
更新日期:2000-03-01 00:00:00
abstract::An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90175-7
更新日期:1988-08-01 00:00:00
abstract::Recent advances in next-generation sequencing have enabled rapid and efficient evaluation of the mutational landscape of cancers. As a result, many cancer-specific neoantigens, which can generate antitumor cytotoxic T-cells inside tumors, have been identified. Previously, we reported a metastatic melanoma case with hi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.02.004
更新日期:2019-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.11.028
更新日期:2004-03-29 00:00:00
abstract::We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90035-o
更新日期:1990-03-01 00:00:00
abstract::The immunomodulating properties of a neuropeptide hormone, corticotropin-releasing factor (CRF), led us to investigate its effect on cAMP production by human peripheral blood mononuclear cells (MNC). In response to stimulation with CRF (100 nM), a statistically significant (P = 0.019) increase occurred in the amount o...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90189-9
更新日期:1993-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.02.015
更新日期:2005-06-15 00:00:00
abstract::HIV-1 positive patients generate Nef-specific CTL response, indicating that Nef is a potent immunogen. However, Nef is also known to down regulate the expression of CD4 and MHC-I molecules, thereby protecting virally infected target cells. We compared the immunogenicity of non-functional nef vaccine constructs to wild...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00141-x
更新日期:2003-10-31 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.05.012
更新日期:2017-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02655-7
更新日期:1996-12-01 00:00:00
abstract::To test whether apoptotic thymocytes can be identified by altered packing of lipids in their plasma membranes, thymocytes were isolated from mice injected with hydrocortisone and stained with merocyanine 540 (MC540), a fluorescent probe sensitive to lipid packing. At 9-10 h after injection, a subpopulation of H2-Klo c...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90101-7
更新日期:1993-06-01 00:00:00
abstract::Based on the cerebral malaria coma scale, 39 falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups of patients that had either cerebral malaria or non-cerebral malaria. We then studied significant pathological differences, such as p...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90115-7
更新日期:1990-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90134-1
更新日期:1982-10-01 00:00:00
abstract::The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...
journal_title:Immunology letters
pub_type: 信件
doi:10.1016/j.imlet.2008.06.002
更新日期:2008-08-15 00:00:00
abstract::The purpose of this study is to show that anti-Leu M1 antibody (anti-CD15), which has different staining characteristics in lymphoid and non-lymphoid cells, reacted against the surface antigen of a defined monoclonal B cell line. This antibody recognizes the sugar moiety, lacto-N-fucopentaose (LNF-III), which is linke...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90153-3
更新日期:1989-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.02.005
更新日期:2013-03-01 00:00:00
abstract::Microparticles are recently recognized players of intercellular communication. They are involved in signal transduction, cell activation and apoptosis. Their importance is also suggested in autoimmune diseases such as rheumatoid arthritis and systemic sclerosis. We investigated the role of microparticles in polymyosit...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.12.018
更新日期:2010-02-16 00:00:00
abstract::Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.05.012
更新日期:2015-08-01 00:00:00
abstract::Differentiation between a non-infective and an infective Leishmania promastigote population was demonstrated. Promastigotes in the stationary phase (day 5) were found to be highly infective in vitro to BALB/c mouse peritoneal macrophages, compared with those of the logarithmic phase (day 3). The infective promastigote...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90114-2
更新日期:1985-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90044-3
更新日期:1993-05-01 00:00:00
abstract::T cell specific, B cell specific and Ia specific polyclonal antisera, as well as monoclonal antibodies, were employed to characterize cells involved in regulation of T cells, proliferating upon stimulation with concanavalin A or phytohaemagglutinin. Evidence for Ia+ accessory cells was obtained and the constellation o...
journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1986-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.10.011
更新日期:2015-12-01 00:00:00
abstract::Partially purified IgE receptor(s) of rat basophilic leukemia cells (RBL) designated R and H and having apparent molecular weight of 45,000 and 55,000 daltons, respectively, were subjected to proteolysis with papain. Polyacrylamide gel electrophoresis of the digests in the presence of sodium dodecyl sulfate revealed a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90029-3
更新日期:1982-03-01 00:00:00
abstract::This paper describes functional and genetic studies on the macrophage resistance gene Lsh/Ity/Bcg first described almost two decades ago. Working in vitro with resident peritoneal, liver (Kupffer cells) and bone marrow derived macrophages from congenic B10 (LshS) and B10.L-LshR mice it has been possible to demonstrate...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90032-6
更新日期:1991-10-01 00:00:00
abstract::N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.06.005
更新日期:2016-09-01 00:00:00
abstract::The human immune system is a complex machinery involving numerous proteins. Proteins located at the cell surface of immune cells are of particular relevance due not only to their participation in the network of interactions that regulate the immune response but also to their potential as excellent targets for diagnost...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.09.016
更新日期:2011-01-30 00:00:00
abstract::Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00166-2
更新日期:2000-01-10 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.06.009
更新日期:2015-09-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective way to cure hematological malignancies. However, graft-versus-host disease (GVHD) following transplantation limits the clinical application to some extent. The donor T lymphocytes play a central role in the occurrence and development of GVH...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2011.01.010
更新日期:2011-05-01 00:00:00
abstract::It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02497-2
更新日期:1996-03-01 00:00:00