Abstract:
:Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role of IC obtained from chronic intestinal schistosomiasis patients (ISP) in the reactivity of peripheral blood mononuclear cells (PBMC). The results have shown that these immune complexes are able to suppress cell reactivity by inducing an increase in the production of soluble mediators such as prostaglandins and IL-10. To gain a better understanding of how this suppression occurs the present study examines the phenotypic pattern of PBMC after immune complex treatment in cell proliferation assays. These data show that cultures including immune complex present a higher percentage of B lymphocytes in which a lower expression of a MHC-class II gene product, HLA-DR was detected. This altered expression of the HLA-DR molecule on B lymphocytes after IC treatment suggests a novel mechanism for the suppression observed, that is, IC might decrease the antigen-presenting function of B lymphocytes.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Rezende SA,Gollob KJ,Correa-Oliveira R,Goes AMdoi
10.1016/s0165-2478(98)00026-1subject
Has Abstractpub_date
1998-06-01 00:00:00pages
67-73issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(98)00026-1journal_volume
62pub_type
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