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Changes in the acute phase complement component and IL-6 levels in patients with chronic hepatitis C receiving interferon alpha-2b.

Abstract：

:In order to study the effect of interferon alpha on the levels of acute phase complement proteins in vivo, serum concentrations of C9 and C1-inhibitor (C1-INH) were measured in patients with chronic hepatitis C before and 3 months after the beginning of interferon alpha2b therapy. Serum levels of the activation product of terminal complement pathway, C5b-9, HCV RNA and IL-6 were also determined. IFN alpha treatment significantly (P<0.0001) increased the serum concentrations of both complement proteins. C5b-9 levels were found to significantly decrease during the same period of time. When the patients were divided into responders or non-responders (more or less than 50% decrease in plasma HCV RNA concentrations) C9 and C1-INH levels were elevated only in the responder patients. There was no correlation between the changes of IL-6 levels or the amounts of IFN alpha administrated on one hand, and the changes in the complement protein levels on the other. These findings suggest that the marked increase in the serum concentrations of the acute phase complement proteins is a secondary phenomenon due to the IFN alpha-caused diminution of the viral load and the resulting immune complex-induced complement activation.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Bíró L,Varga L,Pár A,Nemesánszky E,Csepregi A,Telegdy L,Ibrányi E,Dávid K,Horváth G,Szentgyörgyi L,Nagy I,Dalmi L,Abonyi M,Füst G,Horányi M

doi

10.1016/s0165-2478(00)00183-8

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

69-74

issue

2

eissn

0165-2478

issn

1879-0542

pii

S0165247800001838

journal_volume

72

pub_type

杂志文章

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