A monoclonal antibody demonstrating specificity for drug-resistance cells.

abstract：:In several diseases where the immune system plays an important role there has been a tremendous progress in treatment efficacy during the last decades. Based on necessary basic science these improvements are results of rapid, numerous and open-minded clinical trials where pieces of positive results step by step have b...

journal_title：Immunology letters

authors： Ludvigsson J

更新日期：2014-05-01 00:00:00

abstract：:Interleukin (IL)-17A is a cytokine that plays an important role in infectious, autoimmune, and inflammatory diseases. In this study, we found that TCRγδ(+)CD4(-)CD8(-) T cells, but not TCRαβ(+)CD4(+) T cells, are the primary producers of IL-17A in the genital tract of female mice in the steady-state condition. High mR...

journal_title：Immunology letters

authors： Kim JO,Cha HR,Kim ED,Kweon MN

更新日期：2012-09-01 00:00:00

abstract：:We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...

journal_title：Immunology letters

authors： Torbett BE,Laxer JA,Glasebrook AL

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Integrin αvβ6 can convert the transforming growth factor (TGF)-β precursor to the mature form. Resiquimod (R848) can generate TGF-β-producing regulatory T cells (Treg). Thus, to concurrent administration of specific antigen and R848 may generate antigen-specific Tregs, that is expected to restore immune tole...

journal_title：Immunology letters

authors： Ma F,Zhang YY,Yang G,Mo LH,Liu DB,Yang LT,Liu ZG,Ning Y,Yang PC

更新日期：2021-02-01 00:00:00

abstract：:The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests in...

journal_title：Immunology letters

authors： Takashi T,Kasai M,Tanaka N,Takahashi T,Tokunaga T

更新日期：1985-01-01 00:00:00

abstract：:Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...

journal_title：Immunology letters

authors： Garnica MR,Silva JS,de Andrade Junior HF

更新日期：2003-10-31 00:00:00

abstract：:The mechanism of cytolysis by natural killer cells has been shown to involve a soluble lytic factor - the natural killer cytotoxic factor (NKCF). We have investigated the generation of NKCF on exposure of subpopulations of human blood lymphocytes to autologous B lymphocytes and EBV infected B lymphocytes (BEBV), and t...

journal_title：Immunology letters

authors： Saranath D,Masucci MG,Klein E

更新日期：1986-03-01 00:00:00

abstract：:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...

journal_title：Immunology letters

authors： Kaslow DC,Kumar S

更新日期：1996-07-01 00:00:00

abstract：:The influence of human recombinant granulocyte-macrophage colony-stimulating factor (rH GM-CSF) on respiratory burst response of isolated human neutrophils was examined. Preincubation of cells with rH GM-CSF significantly increased the respiratory burst in response to formyl-methionyl-leucyl-phenylalanine (FMLP), meas...

journal_title：Immunology letters

authors： Leino L,Nuutila J,Pelliniemi TT,Rajamäki A

更新日期：1993-09-01 00:00:00

abstract：:Parenteral administration of antigen induces in the earthworms Lumbricus terrestris and Eisenia foetida the formation of antigen-binding protein. Labelled antigen was efficiently digested in the coelomic fluids of both species since the total amount of radioactivity in the coelomic fluids decreased. Antigen internaliz...

journal_title：Immunology letters

authors： Rejnek J,Tucková L,Síma P,Bilej M

更新日期：1993-05-01 00:00:00

abstract：:The presence of specific glutamate receptors on T lymphocytes separated from normal human blood was investigated. Upon study of T lymphocytes interaction with [3H]glutamate the last one was found to bind specifically to these cells, Kd = 2.36 x 10(-7) M. Thirteen unlabelled compounds were tested as potential glutamate...

journal_title：Immunology letters

authors： Kostanyan IA,Merkulova MI,Navolotskaya EV,Nurieva RI

更新日期：1997-08-01 00:00:00

abstract：:The effect of melphalan (L-PAM; L-phenylalanine mustard) administration on natural killer (NK) and natural cytotoxic (NC) activities of spleen cells from normal noninoculated BALB/c mice and mice bearing large MOPC-315 plasmacytoma tumors was investigated. Injection of L-PAM (7.5 or 15.0 mg/kg) had no effect on NK and...

journal_title：Immunology letters

authors： Nahas F,Ophir R,Ben-Efraim S

更新日期：1985-01-01 00:00:00

abstract：:BAFF deficiency in mice impairs B cell development beyond the transitional stage 1 in the spleen and thus severely reduces the size of follicular and marginal zone B cell compartments. Moreover, humoral immune responses in these mice are dramatically impaired. We now addressed the question whether the decrease in matu...

journal_title：Immunology letters

authors： Swee LK,Tardivel A,Schneider P,Rolink A

更新日期：2010-06-15 00:00:00

abstract：:Diabetes mellitus is associated with an increased incidence of cardiovascular events and microvascular complications. Serum amyloid A (SAA), a HDL apolipoprotein is a risk marker for cardiovascular disease. A permanent increase in SAA plasma levels is observed in diabetics. Because SAA acts on leukocytes, we evaluated...

journal_title：Immunology letters

authors： Hatanaka E,Monteagudo PT,Marrocos MS,Campa A

更新日期：2007-02-15 00:00:00

abstract：:A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...

journal_title：Immunology letters

authors： Krishnaraj R,Bhooma T

更新日期：1996-04-01 00:00:00

abstract：:Oral vaccine responsiveness is often lower in children from less developed countries. Childhood malnutrition may be associated with poor immune response to oral vaccines. The present study was designed to investigate whether protein energy malnutrition (PEM) impairs B cell immunity and ultimately reduces oral vaccine ...

journal_title：Immunology letters

authors： Rho S,Kim H,Shim SH,Lee SY,Kim MJ,Yang BG,Jang MH,Han BW,Song MK,Czerkinsky C,Kim JO

更新日期：2017-10-01 00:00:00

abstract：:Maturation of dendritic cells is a key step during induction of adaptive immune responses. Multiple pathways and factors are involved in the regulation of dendritic cell maturation. Alternative splicing of pre-mRNA, which is regulated by splicing factors, plays an important role in many biological processes, including...

journal_title：Immunology letters

authors： Jia R,Li X,Yu C,Fan M,Guo J

更新日期：2013-06-01 00:00:00

abstract：:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are thought to play key roles in viral control and liver damage. We have used HLA-A*02 tetramer complex to human HBV core 18-27 (Tc 18-27), envelope 183-191 (Te 183-191), envelope 335-343 (Te 335-343), and polymerase 575-583 (Tp 575-583) epitopes to chara...

journal_title：Immunology letters

authors： Wu Y,Zhang J,Chen S,Chen A,Wang L,Li J,Zhao T,Zou L,Tang Y,Tingrong L,Wang F

更新日期：2004-04-15 00:00:00

abstract：:Two cell lines producing monoclonal antibodies have been established from peripheral blood of a negative Rhesus blood donor which has been immunized with positive Rhesus red blood cells. Two monoclonal antibodies Co II 8.8 and Co II 7.12 have been selected. Both are IgG1 antibodies, but recognize different epitopes on...

journal_title：Immunology letters

authors： Paire J,Monestier M,Rigal D,Martel F,Desgranges C

更新日期：1986-09-01 00:00:00

abstract：:The prevalence of asthma and allergic disease has increased in many countries and there has been speculation that immunization promotes allergic sensitization. Bordetella pertussis infection exacerbates allergic asthmatic responses. We investigated whether whole-cell pertussis vaccine (Pw) enhanced or prevented B. per...

journal_title：Immunology letters

authors： Ennis DP,Cassidy JP,Mahon BP

更新日期：2005-02-15 00:00:00

abstract：:To test whether apoptotic thymocytes can be identified by altered packing of lipids in their plasma membranes, thymocytes were isolated from mice injected with hydrocortisone and stained with merocyanine 540 (MC540), a fluorescent probe sensitive to lipid packing. At 9-10 h after injection, a subpopulation of H2-Klo c...

journal_title：Immunology letters

authors： Schlegel RA,Stevens M,Lumley-Sapanski K,Williamson P

更新日期：1993-06-01 00:00:00

abstract：:A fragment of non-glycosylated E2 antigen of classical swine fever virus (CSFV), lacking the trans-membrane anchor (TM-) of the native glycoprotein, was produced in recombinant Escherichia coli strain BL21(DE3) in the form of inclusion bodies. These inclusion bodies isolated from the bacteria cells were administrated ...

journal_title：Immunology letters

authors： Kesik M,Saczyńska V,Szewczyk B,Płucienniczak A

更新日期：2004-02-15 00:00:00

abstract：:We have previously reported that the capacity of highly malignant B16BL6 murine melanoma cells to induce cell death in naive syngeneic lymphocytes stems from the absence of major histocompatibility complex (MHC) class I glycoproteins in these melanoma cells. Our present study provides evidence that the above-mentioned...

journal_title：Immunology letters

authors： Kellman-Pressman S,Fishman D,Tsory S,Segal S

更新日期：2005-09-15 00:00:00

abstract：:We have mapped a T cell epitope in the circumsporozoite (CS) protein of the murine malaria parasite, Plasmodium yoelii. A 21-mer synthetic peptide corresponding to the amino acid positions 59-79 (referred to as Py1), induced specific proliferation in BALB/c and C57BL/6 mice, and provided help for the production of ant...

journal_title：Immunology letters

authors： Del Giudice G,Grillot D,Rénia L,Müller I,Corradin G,Louis JA,Mazier D,Lambert PH

更新日期：1990-08-01 00:00:00

abstract：:An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...

journal_title：Immunology letters

authors： Naiki M,Imai Y,Kamita Y,Osawa T

更新日期：1988-08-01 00:00:00

abstract：:Sequence-comparison indicates existing sequence-similarity between receptor-binding regions of human type 1 IFNs (IFN-alpha, -beta and -omega) and HIV-1 gp41. Previous findings had suggested that the increased levels of antibodies against human IFN-alpha and -beta in HIV-1-infected individuals are associated with a co...

journal_title：Immunology letters

authors： Chen YH,Wu W,Yang J,Sui SF,Sun J,Dierich MP

更新日期：1999-08-03 00:00:00

abstract：:We investigated IgE-mediated allergic responses in a metabolic syndrome model rat strain, SHRSP.Z, which develops obesity and hypertension to cast light on the relationship between metabolic disturbances and allergic responses. IgE-mediated cutaneous anaphylactic responses were severely attenuated in this strain regar...

journal_title：Immunology letters

authors： Sakanaka M,Furuta K,Ichikawa A,Tanaka S

更新日期：2010-01-18 00:00:00

abstract：:Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production b...

journal_title：Immunology letters

authors： Thomson AW,Brown PA,Simpson JG,Whiting PH,Davidson RJ

更新日期：1985-01-01 00:00:00

abstract：:The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in...

journal_title：Immunology letters

authors： Arena A,Gugliandolo C,Stassi G,Pavone B,Iannello D,Bisignano G,Maugeri TL

更新日期：2009-04-27 00:00:00

abstract：:The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...

journal_title：Immunology letters

authors： Stanton T,Maynard M

更新日期：1984-01-01 00:00:00