Abstract:
:The mechanism of cytolysis by natural killer cells has been shown to involve a soluble lytic factor - the natural killer cytotoxic factor (NKCF). We have investigated the generation of NKCF on exposure of subpopulations of human blood lymphocytes to autologous B lymphocytes and EBV infected B lymphocytes (BEBV), and the sensitivity of these lymphocytes to the cytotoxic factor. We present evidence that the low density lymphocytes representing majority of NK cells, can be stimulated to produce NKCF by the autologous B/BEBV cells. Allogeneic B/BEBV cells did not induce NKCF production. Recognition of the autologous B/BEBV cells did not seem to involve Dr antigens. Although the autologous B/BEBV cells could stimulate NKCF production, the NKCF was lytic only to K562 targets. The autologous B/BEBV cells could neither be lysed by the factor produced, nor could these cells absorb the factor.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Saranath D,Masucci MG,Klein Edoi
10.1016/0165-2478(86)90096-9subject
Has Abstractpub_date
1986-03-01 00:00:00pages
141-6issue
2-3eissn
0165-2478issn
1879-0542pii
0165-2478(86)90096-9journal_volume
12pub_type
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pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00