Degenerative changes in the A375 melanoma line induced by transforming growth factor beta 1.


:A375 human melanoma cell cultures grown in the presence of TGF beta contained greatly reduced cell numbers and exhibited drastic alterations in cell morphology compared to the control cultures. Preincubation of the cells with the cytokine for only 18 h was sufficient to induce these changes irreversibly. Examination of TGF beta-treated cells in the electron microscope revealed large numbers of lipid-filled vacuoles in the cytoplasm, greatly contracted nuclei and some loss of the otherwise abundant microvilli. Thus TGF beta may have a direct toxic effect on the A375 melanoma cells.


Immunol Lett


Immunology letters


Larisch-Bloch S,Yarom R,Sulitzeanu D




Has Abstract


1992-07-01 00:00:00














  • Association of MMP-9 gene polymorphisms with Behçet's disease risk.

    abstract::The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to invest...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Naouali A,Kaabachi W,Tizaoui K,Amor AB,Hamzaoui A,Hamzaoui K

    更新日期:2015-03-01 00:00:00

  • Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro.

    abstract::Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. Besides its toxic properties, BPA is also well-known for its antioxidant chemical properties. This in vitro study investigated the interference of BPA with interferon-γ (IFN-γ)-induced tryptophan b...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Gostner JM,Raggl E,Becker K,Überall F,Schennach H,Pease JE,Fuchs D

    更新日期:2015-12-01 00:00:00

  • Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity.

    abstract::Mice were exposed to restraint stress for 3h. During this period, low body temperature (hypothermia, 39 degrees C-->less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150 mg/dl-->up to 220 mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines incr...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Watanabe M,Tomiyama-Miyaji C,Kainuma E,Inoue M,Kuwano Y,Ren H,Shen J,Abo T

    更新日期:2008-01-15 00:00:00

  • The role of TGF-beta superfamily during T cell development: new insights.

    abstract::Members of the transforming growth factor beta (TGF-beta) superfamily are soluble factors that regulate a variety of functional responses including proliferation, differentiation, apoptosis and cell cycle, among others, depending not only on the cell type and its differentiation state, but also on the milieu of cytoki...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Licona-Limón P,Soldevila G

    更新日期:2007-03-15 00:00:00

  • A monoclonal antibody against the human IL-2 receptor binds to paraformaldehyde-fixed but not viable frog (Xenopus) splenocytes.

    abstract::Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Haynes L,Moynihan JA,Cohen N

    更新日期:1990-12-01 00:00:00

  • Chloroquine: modes of action of an undervalued drug.

    abstract::For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Thomé R,Lopes SC,Costa FT,Verinaud L

    更新日期:2013-06-01 00:00:00

  • Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells.

    abstract::ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Gergely J,Pecht I,Sármay G

    更新日期:1999-05-03 00:00:00

  • Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.

    abstract::In transplant rejection, graft versus host or autoimmune diseases T cells are mediating the pathophysiological processes. Compared to unspecific pharmacological immune suppression specific inhibition of those T cells, that are involved in the disease, would be an alternative and attractive approach. T cells are activa...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Neumann F,Sturm C,Hülsmeyer M,Dauth N,Guillaume P,Luescher IF,Pfreundschuh M,Held G

    更新日期:2009-08-15 00:00:00

  • The 'monocytic' cell line I937 displays typical B cell characteristics.

    abstract::The monocytic cell line I937 was derived from U937 by sorting for cells with high expression of MHC class II molecules. Further analysis of these class II molecules revealed the presence of the HLA-DR3 subtype suggesting that the cell line was a potential candidate for testing antigen presentation to T cells restricte...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Reischl IG,Pöllabauer EM,Peiritsch S,Schlager S,Gladstone P,Vooijs WC,Woisetschläger M,Mudde GC

    更新日期:1996-01-01 00:00:00

  • Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-alpha and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia.

    abstract::Pretreatment with interleukin (IL)-10 inhibited the release of growth-related oncogene GRO-alpha but not of epithelial-cell derived neutrophil activating protein (ENA)-78, after injection of lipopolysaccharide (LPS) into healthy humans. In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha ...

    journal_title:Immunology letters

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Olszyna DP,Pajkrt D,van Deventer SJ,van der Poll T

    更新日期:2001-08-01 00:00:00

  • Autoimmune T-lymphocytes with specificity for pancreatic islet antigens.

    abstract::The question is still unresolved whether in insulin-dependent (type I) diabetes T-lymphocytes mediate an autoimmune response towards pancreatic islets. We now present direct evidence in an animal model for autoimmune T-lymphocytes with specificity for islet antigens. Mice of strain C57BL/6 were immunized repeatedly wi...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kolb H,Ben-Nun A,Cohen IR,Barberena I,Kiesel U

    更新日期:1985-01-01 00:00:00

  • Liver nonparenchymal cells involved in hyporesponsiveness induced by portal vein injection of alloantigen.

    abstract:INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Chen Y,McKenna GJ,Ong C,Mui AL,Chung SW

    更新日期:2002-04-01 00:00:00

  • Desensitization of IL-4 secretion from mouse bone marrow-derived mast cells.

    abstract::Several recent findings indicate that mouse bone marrow-derived mast cells (BMMC) express RNA encoding interleukin-4 (IL-4) and secrete detectable amounts of IL-4 in response to cross-linking of Fc epsilon RI receptors, Fc gamma R receptors, or to ionomycin. We investigated the desensitization of BMMC from the view po...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Nakamura M,MacGlashan D Jr

    更新日期:1994-07-01 00:00:00

  • Hepatic phase of malaria is the target of cellular mechanisms induced by the previous and the subsequent stages. A crucial role for liver nonparenchymal cells.

    abstract::Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity ...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Mazier D,Rénia L,Nussler A,Pied S,Marussig M,Goma J,Grillot D,Miltgen F,Drapier JC,Corradin G

    更新日期:1990-08-01 00:00:00

  • Preferential utilisation of deoxycytidine by undifferentiated (peanut positive) tonsillar lymphocytes.

    abstract::Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycy...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Taljanidisz J,Spasokukotskaja T,Sasvári-Székely M,Antoni F,Staub M

    更新日期:1987-06-01 00:00:00

  • Adjuvant effect of liposomes in the autoimmune response to rat male accessory glands.

    abstract::Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Correa SG,Riera CM

    更新日期:1991-04-01 00:00:00

  • Induction and characterization of antisera against terminal and internal peptides of SV40 large T antigen.

    abstract::Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as d...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Friedrich U,Scheidtmann KH,Walter G

    更新日期:1986-04-01 00:00:00

  • Constitutive expression of HLA class II mRNA in synovial fibroblast-like cells from patients with rheumatoid arthritis .

    abstract::We describe the quantification of the absolute amounts of HLA class II mRNA and class II transactivator (CIITA) mRNA by competitive reverse transcription polymerase chain reaction in cultured synovial fibroblast-like cells (SFC) of patients with rheumatoid arthritis. High basal levels of transcription of class II mRNA...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Navarrete Santos A,Riemann D,Thiele K,Kehlen A,Navarrete Santos A,Langner J

    更新日期:1997-06-01 00:00:00

  • Synergistic effect of prolactin on IFN-gamma-mediated growth arrest in human monoblastic cells: correlation with the up-regulation of IFN-gamma receptor gene expression.

    abstract::Interferon-gamma (IFN-gamma) stimulates the development of monocytic features in human myeloid precursors. Because transcriptional regulation of IFN-gamma and the pituitary hormone prolactin (PRL) has been described to involve common Jak-STAT pathways, we addressed here the question of whether PRL plays a role in mono...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Sedo A,Van Weyenbergh J,Rouillard D,Bauvois B

    更新日期:1996-11-01 00:00:00

  • Considering genetic profiles in functional studies of immune responsiveness to HIV-1.

    abstract::Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults ( The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Carrington M,Nelson G,O'Brien SJ

    更新日期:2001-11-01 00:00:00

  • N-Acetyl-l-cysteine exacerbates generation of IL-10 in cells stimulated with endotoxin in vitro and produces antipyresis via IL-10 dependent pathway in vivo.

    abstract::N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Wrotek S,Jędrzejewski T,Piotrowski J,Kozak W

    更新日期:2016-09-01 00:00:00

  • Two screening methods show different antigen recognition patterns for four monoclonal antibodies to Candida albicans cell surface.

    abstract::Four murine monoclonal antibodies (mAbs) showing similar reactivity with a cell-wall extract and mannan preparation obtained from Candida albicans were examined for epitope specificity. An enzyme-linked immunosorbent assay (ELISA) was used to determine total mAb binding to extracted cell-wall antigen when each mAb was...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Chaffin WL,Morrow KJ Jr

    更新日期:1989-07-01 00:00:00

  • Human neonates display altered ex vivo monokine production related to healthy adults.

    abstract::The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an a...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Antas PR,Pedro TQ,Santiago EA,Lima JR,Silva FC,Melca LA,Ponte CG

    更新日期:2016-02-01 00:00:00

  • HIV and human complement: inefficient virolysis and effective adherence.

    abstract::Both, HIV envelope proteins gp120 and gp41 can directly activate complement system, even in the absence of HIV-specific antibodies. During the budding process HIV acquires host membrane-associated molecules among these complement regulatory proteins (CRPs). The presence of CRPs on the viral surface rescues HIV from co...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Bánki Z,Stoiber H,Dierich MP

    更新日期:2005-03-15 00:00:00

  • Targeting PPAR ligands as possible approaches for metabolic reprogramming of T cells in cancer immunotherapy.

    abstract::Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Bahrambeigi S,Molaparast M,Sohrabi F,Seifi L,Faraji A,Fani S,Shafiei-Irannejad V

    更新日期:2020-04-01 00:00:00

  • Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs).

    abstract::Cigarette smoke contains nicotine, an immunomodulatory component that is thought to affect immune surveillance and increase the progression of diseases. Dendritic cells (DCs) constitute a family of antigen-presenting (APCs) with inherent abilities to sense and translate environmental cues and to shape host immunity. W...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Nouri-Shirazi M,Tinajero R,Guinet E

    更新日期:2007-04-15 00:00:00

  • Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery.

    abstract::Type 1 diabetes (T1D) is an autoimmune disease caused by the selective destruction of the insulin-producing β cells. Research into the pathogenesis of T1D has been hindered by the lack of detection of the autoimmune process during the asymptomatic period and by the inaccessibility to the target tissue. Therefore curre...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Planas R,Pujol-Borrell R,Vives-Pi M

    更新日期:2010-10-30 00:00:00

  • Variations of serum IgG subclass levels in hepatitis C virus infection during interferon-alpha therapy.

    abstract::Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual va...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Musset L,Ghillani P,Lunel F,Cacoub P,Cresta P,Frangeul L,Rosenheim M,Preud'homme JL

    更新日期:1997-01-01 00:00:00

  • Follicular helper T cell-mediated mucosal barrier maintenance.

    abstract::The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Winstead CJ

    更新日期:2014-12-01 00:00:00

  • Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1.

    abstract::ErbB2, a member of the EGF receptor family of tyrosine kinases is overexpressed on many tumor cells of epithelial origin and is the molecular target of trastuzumab (Herceptin), the first humanized antibody used in the therapy of solid tumors. Trastuzumab, which is thought to act, at least in part, by downregulating Er...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Zsebik B,Citri A,Isola J,Yarden Y,Szöllosi J,Vereb G

    更新日期:2006-04-15 00:00:00