Abstract:
:The effect of melphalan (L-PAM; L-phenylalanine mustard) administration on natural killer (NK) and natural cytotoxic (NC) activities of spleen cells from normal noninoculated BALB/c mice and mice bearing large MOPC-315 plasmacytoma tumors was investigated. Injection of L-PAM (7.5 or 15.0 mg/kg) had no effect on NK and NC activities of spleen cells from normal mice whereas stimulation by PHA was markedly suppressed. NK activity was markedly suppressed in spleens of tumor-bearing mice whereas NC activity was not affected. Therapy with L-PAM of tumor-bearing mice led to transient recovery of NK activity which was possibly related to the effect of L-PAM on macrophage suppressive activity on NK cells. It is concluded that NK and NC cell activities and the response to PHA stimulation are selectively affected by L-PAM administration.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Nahas F,Ophir R,Ben-Efraim Sdoi
10.1016/0165-2478(85)90128-2subject
Has Abstractpub_date
1985-01-01 00:00:00pages
333-7issue
6eissn
0165-2478issn
1879-0542pii
0165-2478(85)90128-2journal_volume
10pub_type
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pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
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pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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journal_title:Immunology letters
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doi:10.1016/j.imlet.2013.12.014
更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 临床试验,杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90079-4
更新日期:1987-05-01 00:00:00
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更新日期:2003-10-31 00:00:00