Abstract:
:Several studies have implicated a role for the cell surface glycoprotein CD44 in lymphocyte differentiation, adhesion to the matrix, homing, activation and apoptosis. However, the requirement of CD44 in B cell maturation remains elusive. To address this point, we analyzed the generation and activation of B lymphocytes in CD44-deficient mice. Unexpectedly, both maturation and autoreconstitution of early bone marrow B cell progenitors after sublethal irradiation as well as frequencies of splenic B cell subsets are indistinguishable in wild-type and CD44-deficient mice. Furthermore, splenic CD44-deficient B lymphocytes show a normal activation pattern after stimulation with LPS, anti-IgM/IL-4 or anti-CD40/IL-4. These results show for the first time that CD44 is clearly dispensable for development, reconstitution and activation of B lymphocytes.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Bradl H,Schuh W,Jäck HMdoi
10.1016/j.imlet.2004.06.004subject
Has Abstractpub_date
2004-08-15 00:00:00pages
71-5issue
1eissn
0165-2478issn
1879-0542pii
S0165247804001622journal_volume
95pub_type
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pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.01.002
更新日期:2004-04-15 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-30 00:00:00
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更新日期:2014-09-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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journal_title:Immunology letters
pub_type: 杂志文章
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