Abstract：
:Interleukin 18 (IL-18) gene polymorphisms have been reported to be associated with the outcomes of hepatitis C virus (HCV) infection in Americans, Indians and Europeans. We aimed to investigate whether the association can be replicated in Chinese Han population. Three IL-18 variants, -656G>T, -137G>C and +105A>C, were genotyped in three independent Han cohorts consisting of 552 cases and 784 controls. By using logistic regression analysis and multiple testing, haplotype GCC were associated with a protection from susceptibility to HCV. After stratified analysis, both the carriage of -137C allele in the older or hemodialysis subgroup and the carriage of +105C allele in the younger subgroup were found to be significantly associated with a decreased risk of HCV susceptibility. By using logistic regression analysis and multiple testing for the resolution of HCV infection, our study showed that +105C allele and haplotype GGC displayed a negative effect on HCV persistence. After stratified analysis, a significantly decreased risk for HCV persistence was found in +105C allele in the subgroups of young, male or female, drug user or hemodialysis and HCV-1 or HCV mixed genotype. No significant association was observed between -656G>T and the outcomes of HCV infection. Our results demonstrated that the carriage of -137C allele, +105C allele, haplotype -656G/-137C/+105C and haplotype -656G/-137G/+105C of IL-18 gene may contribute to better outcomes of HCV infection in high-risk Chinese Han population.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Yue M,Wang JJ,Tang SD,Feng L,Zhang Y,Liu Y,Wang J,Deng XZ,Xu K,Zhang Jdoi
10.1016/j.imlet.2013.08.007subject
Has Abstractpub_date
2013-07-01 00:00:00pages
54-60issue
1-2eissn
0165-2478issn
1879-0542pii
S0165-2478(13)00109-0journal_volume
154pub_type
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更新日期：1985-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-03-29 00:00:00
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pub_type： 杂志文章
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更新日期：1992-08-01 00:00:00
