Abstract:
:The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) derived from Borrelia burgdorferi strain ZS7. Mice received three doses (1 microgram each) of the antigens adsorbed to aluminum hydroxide. A strong immune response to the vaccine antigen was observed. Mice were challenged after immunization, using Ixodes ricinus nymphal ticks infected with Borrelia burgdorferi strain ZS7. Infection was investigated by ear biopsy culture, xenodiagnosis with uninfected larvae and serological response to Borrelia burgdorferi antigens. All unimmunized control animals were found to be infected, while all immunized animals were found to be protected against infection by Borrelia burgdorferi. In addition, most adult ticks derived from nymphs that fed on immunized mice were found to be free of spirochetes.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Gern L,Rais O,Capiau C,Hauser P,Lobet Y,Simoen E,Voet P,Pêtre Jdoi
10.1016/0165-2478(94)90166-xsubject
Has Abstractpub_date
1994-03-01 00:00:00pages
249-58issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(94)90166-Xjournal_volume
39pub_type
杂志文章abstract::Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line. In Jurkat lymphoma cells, AFP decreases the synthesis of prostaglandins and increases the release of arachidonic acid and leukotrienes. The...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90092-7
更新日期:1987-01-01 00:00:00
abstract::Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2017.08.011
更新日期:2017-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90124-7
更新日期:1989-12-01 00:00:00
abstract::The human immune system is a complex machinery involving numerous proteins. Proteins located at the cell surface of immune cells are of particular relevance due not only to their participation in the network of interactions that regulate the immune response but also to their potential as excellent targets for diagnost...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.09.016
更新日期:2011-01-30 00:00:00
abstract::The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00126-0
更新日期:1998-01-01 00:00:00
abstract::Clonal and oligoclonal populations of gammadelta T cells, with respect to the expression of T cell receptors for antigen (Tcr), have been shown to localize in normal and inflamed tissues. The mechanisms responsible for the tissue-selective accumulation of these subsets are still not known. gammadelta T cells are the p...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00077-7
更新日期:1998-11-01 00:00:00
abstract::Replication-competent retroviruses are not known to encode or induce nuclear antigens that are immunogenic in their natural hosts. We describe here the detection of a human T-lymphotropic virus (type I and type II) associated nuclear antigen (HTLV-NA) by an anticomplement immunofluorescence assay. Antibody to HTLV-NA ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90120-3
更新日期:1986-08-01 00:00:00
abstract::Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90010-y
更新日期:1993-11-01 00:00:00
abstract::When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.02.007
更新日期:2012-03-30 00:00:00
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journal_title:Immunology letters
pub_type: 信件
doi:10.1016/j.imlet.2008.06.002
更新日期:2008-08-15 00:00:00
abstract::Work on mast cells and basophils began with their identification by Paul Ehrlich at the end of the 19th century. Mast cells and basophils were immediately perceived as closely linked cells and early nomenclature formulated by Ehrlich himself, i.e., tissue "Mastzellen" and blood "Mastzellen", reflected this unifying vi...
journal_title:Immunology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.imlet.2011.06.008
更新日期:2011-12-30 00:00:00
abstract::Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4+CD25bri regulatory ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.11.009
更新日期:2017-01-01 00:00:00
abstract::Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90044-q
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes. Therefore, the purpose ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.04.005
更新日期:2013-04-01 00:00:00
abstract::Partially purified IgE receptor(s) of rat basophilic leukemia cells (RBL) designated R and H and having apparent molecular weight of 45,000 and 55,000 daltons, respectively, were subjected to proteolysis with papain. Polyacrylamide gel electrophoresis of the digests in the presence of sodium dodecyl sulfate revealed a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90029-3
更新日期:1982-03-01 00:00:00
abstract::Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.014
更新日期:2014-12-01 00:00:00
abstract::In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively wer...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.11.005
更新日期:2004-02-15 00:00:00
abstract::Transplantation immunologists have long been intrigued by the natural allograft that results from normal mammalian pregnancy. Its general success contrasts with the rejection problems associated with most artifactual organ transplantation and raises intriguing questions concerning the nature of the mechanisms involved...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(88)90001-6
更新日期:1988-04-01 00:00:00
abstract::While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.11.005
更新日期:2005-04-15 00:00:00
abstract:OBJECTIVES:Cytokine production from activated T cells play a pathogenetic role in mucosal lesions of coeliac disease (CD). Active interleukin (IL)-18 is expressed in the small intestinal mucosa in CD but not in healthy controls. IL-18 enhances intercellular adhesion molecule-1 (ICAM-1) expression. We analyzed IL-18 ser...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00243-2
更新日期:2003-02-03 00:00:00
abstract::In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce co...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90115-q
更新日期:1991-05-01 00:00:00
abstract::A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90048-f
更新日期:1991-11-01 00:00:00
abstract::We studied isotype profiles of anti-HIV antibodies (Ab) in HIV-1-infected African patients with high viral loads and major B cell dysfunction. We focussed on IgG1, IgG3, and IgA as these classes and subclasses tend to support neutralizing functions against HIV. Total IgG1, IgG3 and IgA were detected in the plasma of b...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.02.004
更新日期:2004-04-30 00:00:00
abstract::The induction characteristics of major histocompatibility complex (MHC) class I-specific cytotoxic T lymphocytes (CTL) after footpad immunization were studied. Primary CTL were generated in the regional lymph nodes of C57Bl/6 mice by footpad injection with 10(7) irradiated (2000 rad) spleen cells from MHC class I muta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90073-6
更新日期:1994-10-01 00:00:00
abstract::Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02655-7
更新日期:1996-12-01 00:00:00
abstract::Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90090-7
更新日期:1984-01-01 00:00:00
abstract::B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.09.019
更新日期:2011-01-30 00:00:00
abstract::The antischistosomal property of a short course of cyclosporin A (CsA), administered at the time of infection was demonstrated in the rat. In comparison with vehicle-treated controls, no schistosomes were recovered from CsA-treated animals, 18-19 days post infection. Flow cytometric analysis of blood and spleen lympho...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90086-7
更新日期:1988-02-01 00:00:00
abstract::Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90086-1
更新日期:1987-01-01 00:00:00
abstract::Recent data have shown that piperlongumine (PL), an important component of Piper longum fruits, is known to possess anti-inflammatory and vascular-protective activities. This study aimed to examine the therapeutic effects and underlying mechanisms of PL on lupus-prone MRL-Fas(lpr) mice. Female MRL-Fas(lpr) mice were i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.05.001
更新日期:2014-09-01 00:00:00