Abstract：
:Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice contain significantly fewer transformable cells. Infection of Ts16 fetal liver cells by Ab1-MuLV results in a 52- and 12-fold reduction in the frequency of transformation at days 17 and 18 of gestation, respectively. By contrast, the efficiency of transformation with J2 virus, another retrovirus known to transform fetal liver cells, is only mildly (factor 2-3) affected. The Ig gene rearrangements of Ts16 and diploid retrovirally transformed fetal liver cell lines do not differ from one another. This suggests that there is a deficiency in the early stem cell compartment, rather than in the development of pre-B cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Berger CN,Epstein CJdoi
10.1016/0165-2478(92)90092-3subject
Has Abstractpub_date
1992-06-01 00:00:00pages
47-51issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(92)90092-3journal_volume
33pub_type
杂志文章abstract：:Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...
journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2010-05-04 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
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更新日期：1996-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2005-11-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：1987-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2005-04-15 00:00:00
abstract：:This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title：Immunology letters
pub_type： 撤回出版物
doi：10.1016/j.imlet.2017.08.015
更新日期：2017-08-26 00:00:00
