Abstract:
:Histamine and putrescine (a precursor of polyamines) are formed by histidine decarboxylase (HDC) and ornithine decarboxylase (ODC), respectively. Within a few hours after injection of a lipopolysaccharide (LPS) into mice, HDC is induced in the liver, spleen, lung and bone marrow, and ODC is induced in the liver, spleen and bone marrow. Since LPS is known to stimulate the production of various cytokines, the abilities of various cytokines to induce HDC and ODC in the tissues of mice were examined. IL-2, IL-6, IL-8, IFN gamma and M-CSF were ineffective. IL-1 alpha, IL-1 beta, TNF alpha and TNF beta induced HDC and ODC, as does LPS. On the other hand, GM-CSF and G-CSF induced HDC and ODC only in the spleen and bone marrow within a few hours after their injection. These results suggest that, in addition to their roles in inflammation or immune responses, HDC and ODC are also involved in an early stage of hematopoiesis.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Endo Y,Kikuchi T,Takeda Y,Nitta Y,Rikiishi H,Kumagai Kdoi
10.1016/0165-2478(92)90086-4subject
Has Abstractpub_date
1992-06-01 00:00:00pages
9-13issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(92)90086-4journal_volume
33pub_type
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