Abstract:
:Serum antibodies reactive with intermediate filaments of the cytoskeleton (anti-IF antibodies) are often present in infectious mononucleosis, some other viral diseases, and rheumatoid arthritis. The mechanism of their production is not known, but it is possible that the formation of this and other autoantibodies result from polyclonal activation of B-cells. Peripheral blood mononuclear cells from subjects with or without serum anti-IF antibody were therefore cultured in the presence or absence of Epstein-Barr virus (EBV). IgM anti-IF antibody was produced in both unfractionated and T-cell-depleted cultures, but not in the supernatants of the same cells cultured without added EBV.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Mortazavi-Milani SM,Stierle HE,Holborow EJdoi
10.1016/0165-2478(82)90135-3subject
Has Abstractpub_date
1982-10-01 00:00:00pages
203-5issue
4eissn
0165-2478issn
1879-0542pii
0165-2478(82)90135-3journal_volume
5pub_type
杂志文章abstract::To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted durin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90201-1
更新日期:1994-04-01 00:00:00
abstract::Inflammation elicits an acute phase response, which includes changes in plasma concentrations of a number of cytokines, reflecting changes in their gene transcription in the liver. In this study, the induction of complement factor 3 (C3) was investigated in HepG2 cells, a human hepatoma cell line often used as a model...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00180-8
更新日期:2001-03-01 00:00:00
abstract::SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90102-1
更新日期:1986-03-01 00:00:00
abstract::Linoleic and arachidonic acid concentrations in neutrophils from rats maintained on a diet with only 0.3% of the energy content as essential fatty acid (EFA, EFAD group) were reduced by 70 +/- 2.2% and 34.8 +/- 5.2%, respectively, compared with controls fed a diet with a normal 3% EFA content. Neutrophil chemiluminesc...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90053-2
更新日期:1986-10-01 00:00:00
abstract::The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was to establish the time-dependent relation between plasma cytokines interleukin (IL)-10, transforming growth factor (TGF)-beta1, ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.07.009
更新日期:2004-09-01 00:00:00
abstract::A consensus motif for a bovine major histocompatibility complex (MHC) class I molecule, A20, was derived from parainfluenza type-3 (PI-3) virus-infected muscle-derived fibroblast cells and peripheral blood leukocytes by extraction of the naturally processed peptides from MHC class I molecules by treatment with TFA and...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)00244-l
更新日期:1995-02-01 00:00:00
abstract::This study was to investigate the role of macrophage migration inhibitory factor (MIF) in mouse acute otitis media (AOM), we hypothesize that blocking MIF activity will relieve mouse AOM. A mouse AOM model was constructed by injecting lipopolysaccharide (LPS) into the middle ear of C57BL/6 mice through the tympanic me...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.07.013
更新日期:2014-11-01 00:00:00
abstract::The monoclonal antibody (mAb) AHT-107 recognized a determinant distal to the interleukin 2 (IL-2) binding site on the p55 subunit of the IL-2 receptor (IL-2R) (the Tac antigen, CD25) of human T lymphoblasts, while the mAb AHT-54 recognized a determinant close to the IL-2 binding site as did the anti-Tac. The AHT-107 i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90081-3
更新日期:1989-02-01 00:00:00
abstract::Tuberculosis is an infectious disease that affects millions of people worldwide with an annual mortality rate of 1.3 million. The mechanisms contributing to the loss of balance of immune responses and progression to active tuberculosis disease are unknown. Although CD4+ and CD8+ T cells and the cytokines they produce ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.03.009
更新日期:2014-07-01 00:00:00
abstract::A docile substrain of lymphocytic choriomeningitis virus (LCMV) causes a persistent infection in adult C3HeB mice and induces a severe autoimmune hemolytic anemia (AIHA) which is maximal around three weeks post infection (PI). Evaluations of serum immunoglobulin levels of these mice demonstrated grossly elevated IgG2a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90126-9
更新日期:1992-02-15 00:00:00
abstract::Culture of high density resting murine B cells with recombinant IL-4 caused changes in the patterns of phosphoproteins associated with the plasma membranes isolated from such cells. The principal difference was the appearance of an alkali-resistant phosphoprotein of Mr = 75,000-80,000. Culture with LPS also gave rise ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90195-8
更新日期:1989-09-01 00:00:00
abstract::Heat-killed Saccharomyces cerevisiae (HKSC) is an agonist for Dectin-1, a major fungal cell wall β-glucan receptor. We previously reported that HKSC selectively enhances IgG1 production by LPS-activated mouse B cells. To determine if this IgG1 selectivity is caused by selective IgG1 class switching, we performed RT-PC...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.08.010
更新日期:2016-10-01 00:00:00
abstract::Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00166-2
更新日期:2000-01-10 00:00:00
abstract::Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.10.020
更新日期:2006-03-15 00:00:00
abstract::This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90046-x
更新日期:1985-01-01 00:00:00
abstract::Yolkin is a product of proteolytic degradation of vitellogenin, a protein contained in eggs' yolk, with already described procognitive properties. Here, we investigated effects of yolkin on the humoral and cellular immune response in mice, phenotype of cells from lymphoid organs and function of innate immunity cells. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.01.003
更新日期:2020-04-01 00:00:00
abstract::Nervous and immune systems share specific recognition molecules for signals that originate in both systems. The information substances are polypeptides and their receptors. They comprise the multi-directional information exchange network whereby brain and nervous system function including mood and emotion can be integ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(87)90171-4
更新日期:1987-12-01 00:00:00
abstract::Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system (CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the CNS. In the initial phase of MS and its animal model, experimental autoimmune encephalomyelitis (EAE), peripheral macrophages infi...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.03.006
更新日期:2014-07-01 00:00:00
abstract::Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD2...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2010.01.007
更新日期:2010-03-10 00:00:00
abstract::Age-related changes of different individuals multicentric and polymorphic. We have approached this problem of age-related changes by examining (1) membrane densities of receptors of various ligands in different organs, and (2) changes in different classes of T cells and of antibody response. Three strategies have been...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(87)90147-7
更新日期:1987-12-01 00:00:00
abstract::Pretreatment with interleukin (IL)-10 inhibited the release of growth-related oncogene GRO-alpha but not of epithelial-cell derived neutrophil activating protein (ENA)-78, after injection of lipopolysaccharide (LPS) into healthy humans. In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha ...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-2478(01)00224-3
更新日期:2001-08-01 00:00:00
abstract::A theoretical analysis of experimental data is presented in this mini-review on non-random homo- and hetero-associations of cell surface receptors, which can be recruited in the plasma membrane or at the surface of the rough endoplasmic reticulum during the protein synthesis. In the latter case, the likely genetic ori...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(02)00024-x
更新日期:2002-06-03 00:00:00
abstract::Two crucial mediators of monocyte activation by lipopolysaccharide (LPS) are the acute phase plasma factor, lipopolysaccharide binding protein (LBP) and cell-surface-expressed CD14. Whether macrophage (M phi) recognized and respond to LPS in a similar manner is unknown. Here we show that human monocyte-derived M phi r...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02645-4
更新日期:1996-12-01 00:00:00
abstract::Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.09.026
更新日期:2013-11-01 00:00:00
abstract::A considerable body of evidence from various laboratories indicates that specific T cell responses generated during infection with Leishmania parasites play an important role both in the resolution and progression of cutaneous leishmaniasis. Recent data, summarized in this article, indicate that resolution of lesions ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90151-4
更新日期:1988-11-01 00:00:00
abstract::Recent data have shown that piperlongumine (PL), an important component of Piper longum fruits, is known to possess anti-inflammatory and vascular-protective activities. This study aimed to examine the therapeutic effects and underlying mechanisms of PL on lupus-prone MRL-Fas(lpr) mice. Female MRL-Fas(lpr) mice were i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.05.001
更新日期:2014-09-01 00:00:00
abstract::After exposure to a concanavalin A (Con A)-unreactive variant of alpha 1-acid glycoprotein (AGP), macrophages released an inhibitor of interleukin-1 (IL-1) proliferative activity in the thymocyte comitogenic assay. This effect was observed with AGP concentrations above 100 micrograms/ml in the macrophage supernatant a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90184-r
更新日期:1990-10-01 00:00:00
abstract::Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and C...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(00)00285-6
更新日期:2000-12-01 00:00:00
abstract::The T cell receptor of gamma delta is normally expressed on a small percentage of peripheral lymphocytes. Although the role of gamma delta T cells in the physiologic immune response is still unknown, there is accumulating evidence that gamma delta T cells may participate in the immune response to mycobacterial and oth...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90105-y
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Notch pathway is highly conserved across species and is involved in the regulation of cell differentiation and activity both in embryonic development and adult life. Notch signaling has an important role in the development of hematopoietic stem cells and their differentiation to committed lineages, as well a...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.04.010
更新日期:2020-07-01 00:00:00