Abstract：
:Culture of high density resting murine B cells with recombinant IL-4 caused changes in the patterns of phosphoproteins associated with the plasma membranes isolated from such cells. The principal difference was the appearance of an alkali-resistant phosphoprotein of Mr = 75,000-80,000. Culture with LPS also gave rise to a characteristic alteration in phosphoprotein profiles, but this was distinct from the cytokine-induced changes and did not include induction of a 75 kDa signal. Culture in medium plus serum only failed to produce an alteration of the phosphoprotein profile of membranes isolated from B cells cultured in this manner. Culture of high density murine splenic B cells with IL-4 in the presence of the 11B11 anti-IL-4 monoclonal antibody prevented the appearance of the 75 kDa phosphoprotein, indicating that IL-4 binding was necessary for induction of the 75 kDa phosphoprotein signal. The possible molecular identity of the 75 kDa phosphoprotein and its role in control of B lymphocyte differentiation is discussed.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
McGarvie GM,Cushley Wdoi
10.1016/0165-2478(89)90195-8subject
Has Abstractpub_date
1989-09-01 00:00:00pages
221-6issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(89)90195-8journal_volume
22pub_type
杂志文章abstract：:Based on the cerebral malaria coma scale, 39 falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups of patients that had either cerebral malaria or non-cerebral malaria. We then studied significant pathological differences, such as p...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90115-7
更新日期：1990-08-01 00:00:00
abstract：:The effect of B cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. Thirteen CBA mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse Ig antibody from 24 hours to 8 weeks after birth. Controls were given normal rabbit IgG (...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90063-1
更新日期：1989-01-15 00:00:00
abstract：:Opioid receptors are expressed not only on neuroendocrine cells but also on immunocompetent cells such as lymphocytes, monocytes and macrophages. micro-Opioid receptor agonists were found to exert immunosuppressive effects, whereas delta-opioid receptor agonists have been shown to act as immunostimulants. delta-Opioid...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.006
更新日期：2008-06-15 00:00:00
abstract：:The cell-surface glycoproteins encoded by the major histocompatibility complex (MHC) bind to processed foreign antigens and present them to T lymphocytes. Two classes of MHC molecules and their corresponding gene sequences have been extensively studied in eutherian mammals and birds, but data on the marsupial MHC are ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00314-x
更新日期：2001-02-01 00:00:00
abstract：:Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line. In Jurkat lymphoma cells, AFP decreases the synthesis of prostaglandins and increases the release of arachidonic acid and leukotrienes. The...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90092-7
更新日期：1987-01-01 00:00:00
abstract：:In this study, we tried to establish a relationship between the immunopotentiating effects and the antioxidant activity of the immunostimulating compound, diethyldithiocarbamate (DDC). We studied the effects of DDC treatment on enriched T and B murine spleen lymphocytes in an in vivo-ex vivo model of O2-induced immune...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90048-x
更新日期：1988-06-01 00:00:00
abstract：:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90056-7
更新日期：1984-01-01 00:00:00
abstract：:The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.06.005
更新日期：2012-09-01 00:00:00
abstract：:Secondary lymphoid organs (SLO) are crucial structures for immune-surveillance and rapid immune responses allowing resident lymphocytes to encounter antigen-presenting cells that carry antigens from peripheral tissues. These structures develop during embryonic life through a tightly regulated process that involves int...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.08.001
更新日期：2013-11-01 00:00:00
abstract：:N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.06.005
更新日期：2016-09-01 00:00:00
abstract：:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2016.07.004
更新日期：2016-11-01 00:00:00
abstract：:We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90197-x
更新日期：1990-01-01 00:00:00
abstract：:Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.06.002
更新日期：2014-11-01 00:00:00
abstract：:Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence tumor cell-induced T-cell d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.10.003
更新日期：2010-01-04 00:00:00
abstract：:Abnormal activation of the transcriptional factor STAT3 (signal transducer and activator of transcription 3) was recently associated with Alzheimer Disease (AD). STAT3 phosphorylation is critical for cytokine secretion linked to neuroinflammation. Moreover, STAT3 may act as a transcriptional regulator of BACE1 (β-APP ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.10.004
更新日期：2020-12-01 00:00:00
abstract：:Homogeneous IgG fractions were obtained by chromatography of the sera of patients with multiple sclerosis (MS) on Protein G-Sepharose under conditions that remove non-specifically bound proteins. These IgGs contained several chelated metals, the relative amount of which decreases in the order: Fe>or=Ca>Cu>or=Zn>or=Mg>...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.018
更新日期：2006-02-28 00:00:00
abstract：:In human tumors of neuroectodermal origin cell surface expression of individual gangliosides is either increased or decreased relative to comparable normal cells. We have previously shown that gangliosides shed from melanoma cells can immunomodulate T cell activity. Monocytes/macrophages (m/m) are known to play an imp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90034-5
更新日期：1989-03-01 00:00:00
abstract：:The role of the immune system in the defense against cancer, a process termed tumor immunosurveillance, has been extensively studied. Evidence is accumulating that the molecular organization of proteins and lipids in the plasma membrane of immune cells is of critical importance. Tetraspanin proteins are expressed in t...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2011.03.010
更新日期：2011-08-30 00:00:00
abstract：:Between the ages of 2 to approximately 11 days mice respond to a challenge with syngeneic IgE by producing anti-IgE antibodies; by the age of 2 weeks they are unresponsive. Even adult mice, however, produce high titers of anti-IgE antibodies when immunized with a conjugate of syngeneic IgE and a foreign antigen such a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00087-3
更新日期：1995-09-01 00:00:00
abstract：:The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1-8 h)- and concentration (1-30 μM)-dependently increased the HO-1 mRNA and protein expression associated with increased...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.01.003
更新日期：2011-05-01 00:00:00
abstract：:Non-Alcoholic Fatty Liver Disease (NALD) is considering a hepatic manifestation of metabolic syndrome. Although the pathogenesis of NALD is not completely understood, insulin resistance and inflammatory cytokines are implicated. Considering that component C5 is a central mediator of inflammation, we investigated the r...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.07.014
更新日期：2016-09-01 00:00:00
abstract：:Incorporation of [3h]thymidine ([3H]TdR) into concanavalin A (Con A)-stimulated murine splenocytes was found to be enhanced by addition of certain concentrations of ethanol, 2-propanol and acetone. The alcohol/acetone-induced enhancement of the Con A response was found to be accompanied by an increase of the percentag...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90057-8
更新日期：1982-06-01 00:00:00
abstract：:In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively wer...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.11.005
更新日期：2004-02-15 00:00:00
abstract：:The purpose of this study is to show that anti-Leu M1 antibody (anti-CD15), which has different staining characteristics in lymphoid and non-lymphoid cells, reacted against the surface antigen of a defined monoclonal B cell line. This antibody recognizes the sugar moiety, lacto-N-fucopentaose (LNF-III), which is linke...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90153-3
更新日期：1989-11-01 00:00:00
abstract：:An effective HIV vaccine will likely need to induce potent and broad-based immunity, including CD8+ T cell responses. Hence, a quantitative assay to measure such responses in animal models will be important in the evaluation of candidate HIV vaccines. We show here that a single immunization with HIV DNA vaccines, foll...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00237-7
更新日期：2003-01-22 00:00:00
abstract：:Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the presen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.03.012
更新日期：2018-06-01 00:00:00
abstract：:H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90111-0
更新日期：1982-11-01 00:00:00
abstract：:Monoclonal antibodies of the Orthoclone series were used to identify total T lymphocytes (OKT3) and their helper-inducer (OKT4) and cytotoxic-suppressor (OKT8) subsets in 25 patients with chronic Chagas' disease and 25 healthy controls. No significant difference in the number of total T cells (OKT3+) circulating in th...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90011-7
更新日期：1984-01-01 00:00:00
abstract：:Soluble C3d applied to human blood-derived B lymphocytes inhibited anti-mu, T cell-produced growth factor, and EBV-induced DNA synthesis in serum-free culture. C3d added to the B cell cultures 1 and 2 days after the stimulus, still exerted inhibition, though with gradually diminishing efficiency. C3d, fixed on zymosan...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90175-p
更新日期：1990-10-01 00:00:00
abstract：:A broad array of biological responses including cell polarization, movement, immune and inflammatory responses, as well as prevention of HIV-1 infection, are triggered by the chemokines, a family of secreted and structurally related chemoattractant proteins that bind to class A-specific seven-transmembrane receptors l...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2012.04.012
更新日期：2012-07-30 00:00:00
