Abstract:
:Immunoselection screening methods were developed for the detection of the free heavy chain determinants of biological fluids. The optimal sensitivity range of the electrosyneresis and electroimmunoassay type methods lies between 400 ng and 2 micrograms/ml and between 3 micrograms and 1 mg/ml for immunoglobulins. The sensitive, relatively rapid and cheap variants of the procedure are suitable for the detection of "heavy chain diseases" and of heavy chain fragments.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Ottó S,Végh Z,Kocsis Gdoi
10.1016/0165-2478(84)90080-4subject
Has Abstractpub_date
1984-01-01 00:00:00pages
211-4issue
4eissn
0165-2478issn
1879-0542pii
0165-2478(84)90080-4journal_volume
8pub_type
杂志文章abstract:OBJECTIVE:Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the curre...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.11.005
更新日期:2019-08-01 00:00:00
abstract::The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90078-7
更新日期:1986-01-01 00:00:00
abstract::IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting with a previously isolated cDNA clone encoding human gp130, recombinant soluble gp130 (sgp130) lacking the transmembrane and cytoplasmic r...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90138-e
更新日期:1992-02-01 00:00:00
abstract::Opioid receptors are expressed not only on neuroendocrine cells but also on immunocompetent cells such as lymphocytes, monocytes and macrophages. micro-Opioid receptor agonists were found to exert immunosuppressive effects, whereas delta-opioid receptor agonists have been shown to act as immunostimulants. delta-Opioid...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.03.006
更新日期:2008-06-15 00:00:00
abstract::A major factor in the ability of the placenta to avoid allograft rejection is the differential expression of MHC class I antigens on its surface. Using monoclonal antibodies and the electron microscopic immunogold technique, we have demonstrated that only the pregnancy-associated (Pa) antigen, which carries a broadly ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90157-x
更新日期:1987-12-01 00:00:00
abstract::In transgenic mice over-expressing CD200 (CD200(tg)) graft survival is associated with increased intra-graft expression of mRNAs for genes associated with altered T cell subset differentiation (Foxp3; TGFβ; IL-10). Grafts are rejected in recipients lacking the inhibitory receptor for CD200, CD200R1. We compared grafts...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.11.004
更新日期:2013-01-01 00:00:00
abstract::Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.06.009
更新日期:2015-09-01 00:00:00
abstract::Non-Alcoholic Fatty Liver Disease (NALD) is considering a hepatic manifestation of metabolic syndrome. Although the pathogenesis of NALD is not completely understood, insulin resistance and inflammatory cytokines are implicated. Considering that component C5 is a central mediator of inflammation, we investigated the r...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.07.014
更新日期:2016-09-01 00:00:00
abstract::The expression of antigen presenting MHC class I molecules can be enhanced through cytokines, e.g. upon infection with bacteria or viruses, either directly by enhancing class I gene transcription or by increasing the amounts of accessory proteins of the loading complex. Tapasin plays a significant role in the peptide ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00104-9
更新日期:2002-10-01 00:00:00
abstract::Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00290-0
更新日期:2003-03-03 00:00:00
abstract::Although several components of the microbial wall of gram-positive bacteria and fungi possess immunostimulatory properties, their pathogenetic role remains incompletely evaluated. The purpose of this study was to assess the basic immune status of patients susceptible to infections and their capability for cytokine pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.12.014
更新日期:2014-05-01 00:00:00
abstract::Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2007.12.008
更新日期:2008-03-15 00:00:00
abstract::Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90040-8
更新日期:1983-01-01 00:00:00
abstract::The role of the immunomodulator Protein A (PA) (from Staphylococcus aureus, Cowan I strain) in the control of leishmanial infection was studied in experimental animals. Treatment of Leishmania donovani infected hamsters with PA led to a moderate level of reduction of parasite load in their spleen (68%) and liver (46%)...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00102-3
更新日期:1999-02-01 00:00:00
abstract::As one studies more and more the immune systems of invertebrates their multiplicity and diversity increase. On one hand, the number of different local and systemic innate mechanisms (or cascades of mechanisms) increases with every phylum studied, on the other hand the diversity increases within each system as multiple...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2003.10.012
更新日期:2004-03-29 00:00:00
abstract::Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, di...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.06.009
更新日期:2020-09-01 00:00:00
abstract::DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00235-8
更新日期:2001-09-03 00:00:00
abstract::This study was to investigate the role of macrophage migration inhibitory factor (MIF) in mouse acute otitis media (AOM), we hypothesize that blocking MIF activity will relieve mouse AOM. A mouse AOM model was constructed by injecting lipopolysaccharide (LPS) into the middle ear of C57BL/6 mice through the tympanic me...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.07.013
更新日期:2014-11-01 00:00:00
abstract::Protective immunity against Salmonella infection is known to require CD4 Th1 cells and B cells, but the role of MHC class-I-restricted CD8 T cells is less clear. Previous studies have suggested that CD8 T cells participate in secondary, but not primary, bacterial clearance. However, these studies have used experimenta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.10.009
更新日期:2012-12-17 00:00:00
abstract::Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.05.012
更新日期:2015-08-01 00:00:00
abstract::Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.05.002
更新日期:2013-05-01 00:00:00
abstract::Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.06.002
更新日期:2014-11-01 00:00:00
abstract::Proliferation of mouse lymph node lymphocytes in response to concanavalin A in serum-free medium is normally dependent upon the presence of transferrin. In the absence of transferrin, little proliferation occurred, but the response was restored by addition of the iron complex of pyridoxal isonicotinoyl hydrazone (FePI...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90071-x
更新日期:1987-05-01 00:00:00
abstract::Recent data provide evidence that antigen-specific CD4+ T-cell clones or antigen-activated T-cell lines can kill antigen-presenting cells (APC). We focused our studies on monocytes acting as APC in cultures of T cells freshly isolated from peripheral blood. The presence of monocytes in culture was monitored by their a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00051-6
更新日期:1995-06-01 00:00:00
abstract::Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90010-y
更新日期:1993-11-01 00:00:00
abstract::Control animals and rats infected 90 days earlier, by inoculation of 1 x 10(6) trypomastigotes of Trypanosoma cruzi at weaning, were subjected to adult thymectomy (ATx) or sham operation (S-ATx) and assessed 3 months later for the presence of myocardial lesions and levels of lymph node and spleen T-cell populations. C...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90028-z
更新日期:1993-08-01 00:00:00
abstract::Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD2...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2010.01.007
更新日期:2010-03-10 00:00:00
abstract::Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.06.011
更新日期:2020-10-01 00:00:00
abstract::The antibody (Ab) response induced by DNA-based immunization was compared in various strains of inbred, H-2 congenic and outbred mice with different haplotypes of mouse major histocompatibility complex (H-2). Two different plasmid expression vectors encoding Aequorea victoria green fluorescent protein (GFP) or Escheri...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00266-2
更新日期:2000-11-01 00:00:00
abstract::Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site. Mutational analyses reve...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.10.015
更新日期:2006-03-15 00:00:00