Abstract:
:There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of heart allograft rejection. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived innate immune activators that have multiple functions in the regulation of immunity and inflammation. Recent discoveries have illustrated the close link between HMGB1 and heart allograft rejection. In this review, we summarize current knowledge of the function of HMGB1 as a ligand that can evoke inflammatory responses and ultimately cause rejection after heart transplantation.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Lv Q,Li C,Mo Y,He Ldoi
10.1016/j.imlet.2017.11.014subject
Has Abstractpub_date
2018-02-01 00:00:00pages
1-3eissn
0165-2478issn
1879-0542pii
S0165-2478(17)30414-5journal_volume
194pub_type
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pub_type: 杂志文章
doi:10.1016/0165-2478(90)90031-k
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.imlet.2005.10.020
更新日期:2006-03-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00039-x
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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doi:10.1016/0165-2478(91)90084-n
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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