Abstract：
:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to presynaptic modulation. This modulation operates through stimulation of alpha 2B-adrenoreceptors, N-nicotinic, P1-purinergic and prostaglandin E2 presynaptic receptors. Through these receptors the release of NA, i.e., the message from the central nervous system to the thymus, can be affected by endogenous ligands or drugs. A novel, potent and highly selective competitive antagonist of the alpha 2-adrenoreceptor, CH-38083, significantly enhanced the release of NA, suggesting that its release in the thymus is under tonic inhibitory control exerted by endogenously released NA. Since adrenoreceptors on thymocytes involved in the modulation of certain thymocyte functions have recently been described, it is suggested that the presynaptic modulation of the release of NA in the thymus is involved in neuro-immune communication.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Haskó G,Elenkov IJ,Vizi ESdoi
10.1016/0165-2478(95)00085-jsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
133-7issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(95)00085-Jjournal_volume
47pub_type
杂志文章abstract：:Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice conta...
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journal_title：Immunology letters
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更新日期：1986-04-01 00:00:00
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journal_title：Immunology letters
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journal_title：Immunology letters
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更新日期：1998-11-01 00:00:00
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journal_title：Immunology letters
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更新日期：2014-07-01 00:00:00
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journal_title：Immunology letters
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更新日期：2016-09-01 00:00:00
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journal_title：Immunology letters
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更新日期：1993-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.009
更新日期：2017-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.02.011
更新日期：2005-07-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90169-4
更新日期：1994-03-01 00:00:00
abstract：:We have described a monoclonal antibody with specificity for permeability-altered drug-resistant cells. This gamma G2b antibody was characterized by antibody-mediated complement-dependent cytotoxicity and by immunofluorescence analysis using a flow cytometer-cell sorter. Further experiments with the flow cytometer sho...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90084-0
更新日期：1982-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90056-3
更新日期：1987-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.01.002
更新日期：2013-02-01 00:00:00
abstract：:Human deficiency in transporter associated with antigen processing (TAP) is characterized by a very low surface expression of human leukocyte antigen (HLA) class I molecules in hematopoietic and non hematopoietic cells. Among the latter, TAP-deficient skin fibroblasts have previously been shown by us to be very sensit...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.07.010
更新日期：2006-11-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.12.009
更新日期：2014-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90134-1
更新日期：1982-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90040-x
更新日期：1987-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.001
更新日期：2008-06-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.03.001
更新日期：2009-04-27 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.04.005
更新日期：2013-04-01 00:00:00
abstract：:Sequence-comparison indicates existing sequence-similarity between receptor-binding regions of human type 1 IFNs (IFN-alpha, -beta and -omega) and HIV-1 gp41. Previous findings had suggested that the increased levels of antibodies against human IFN-alpha and -beta in HIV-1-infected individuals are associated with a co...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00098-x
更新日期：1999-08-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90072-x
更新日期：1990-02-01 00:00:00
abstract：:Pulmonary intraparenchymal leukocytes were purified from normal mice. By flow cytometry, 20-30% of the lymphocytes were positive for the expression of Mac1, a cell-surface antigen largely restricted to macrophages, neutrophils and natural killer (NK) cells. Sorted Mac1+ lung lymphocytes were large and had abundant cyt...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00034-3
更新日期：1995-05-01 00:00:00
abstract：:Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.12.008
更新日期：2008-03-15 00:00:00
abstract：:Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by the destruction of insulin-secreting β cells upon autoreactive T cell attack. Oral administration of autoantigens is an attractive approach to treating T1DM, but an effective carrier should be used in order to protect antigens. Lactococcu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.008
更新日期：2016-06-01 00:00:00
