Abstract:
:Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycytidine kinase as well as the incorporation of [5-3H]deoxycytidine were also much higher in PNA+ cell fraction than in PNA- fraction (7.7-fold and 6-fold, respectively). On the other hand, thymidine kinase activity and [5-3H]deoxythymidine incorporation were only 3.6 and 3.9 times higher, respectively. The data presented here show a high degree of DNA synthesis and preferential utilisation of [5-3H]deoxycytidine for DNA synthesis in this undifferentiated B lymphocyte fraction.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Taljanidisz J,Spasokukotskaja T,Sasvári-Székely M,Antoni F,Staub Mdoi
10.1016/0165-2478(87)90040-xsubject
Has Abstractpub_date
1987-06-01 00:00:00pages
109-15issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(87)90040-Xjournal_volume
15pub_type
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
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