Abstract：
:Whilst many physiological functions of nitric oxide (NO) have been revealed so far, recent evidence proposes an essential role for NO in T lymphocyte activation and signal transduction. NO acts as a second messenger, activating soluble guanyl cyclase and participating in signal transduction pathways involving cyclic GMP. NO modulates mitochondrial events that are involved in apoptosis and regulates mitochondrial biogenesis in many cell types, including lymphocytes. Several studies undertaken on patients with RA and SLE have documented increased endogenous NO synthesis, although the effects of NO may be distinct. Here, we discuss recent evidence that NO contributes to T cell dysfunction in both SLE and RA by altering multiple signaling pathways in T cells. Although NO may play a physiological role in lymphocyte cell signaling, its overproduction may perturb T cell activation, differentiation and effector responses, each of which may contribute in different ways to the pathogenesis of autoimmunity.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Nagy G,Clark JM,Buzás EI,Gorman CL,Cope APdoi
10.1016/j.imlet.2007.04.013subject
Has Abstractpub_date
2007-07-31 00:00:00pages
1-5issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(07)00104-6journal_volume
111pub_type
杂志文章,评审abstract：:The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heteroge...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90177-5
更新日期：1994-05-01 00:00:00
abstract：:Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and C...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(00)00285-6
更新日期：2000-12-01 00:00:00
abstract：:Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.009
更新日期：2007-03-15 00:00:00
abstract：:In this study, we examined the cytokine production by human peripheral blood mononuclear cells (PBM) from recipients of orthotopic liver transplants which had been stimulated by donor-specific alloantigen. Levels of interleukin (IL)-2, IL-4, interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta produ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00061-3
更新日期：1998-09-01 00:00:00
abstract：:The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary resident macrophages, but is killed by activated macrophages. Pretreatment of human macrophages with recombinant IFN-gamma and to a lesser extent with TNF-alpha, induced a significant trypanocidal activity. Furthermore, TNF-alpha...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90090-b
更新日期：1992-06-01 00:00:00
abstract：:Heat-killed Saccharomyces cerevisiae (HKSC) is an agonist for Dectin-1, a major fungal cell wall β-glucan receptor. We previously reported that HKSC selectively enhances IgG1 production by LPS-activated mouse B cells. To determine if this IgG1 selectivity is caused by selective IgG1 class switching, we performed RT-PC...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.08.010
更新日期：2016-10-01 00:00:00
abstract：:In order to study the effect of interferon alpha on the levels of acute phase complement proteins in vivo, serum concentrations of C9 and C1-inhibitor (C1-INH) were measured in patients with chronic hepatitis C before and 3 months after the beginning of interferon alpha2b therapy. Serum levels of the activation produc...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00183-8
更新日期：2000-05-01 00:00:00
abstract：:During a pathogenic infection, an inflammatory process is triggered in which several inflammatory mediators, such as cytokines, chemokines, growth factors, complement system components, nitric oxide, and others induce integrity alteration on the endothelial barrier. Chemokines are responsible for regulating leukocyte ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2019.06.001
更新日期：2019-08-01 00:00:00
abstract：:A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02519-9
更新日期：1996-04-01 00:00:00
abstract：:Lymphoid cell infiltration of periodontal tissues undergoing pathological destruction suggests a functional interdependence between connective tissue proteins such as collagen, fibronectin and elastin and mononuclear cells, mainly T lymphocytes. The aim of the study was to assess T lymphocyte proliferation after stimu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00060-1
更新日期：1998-10-01 00:00:00
abstract：:Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characteriz...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2021.01.001
更新日期：2021-01-06 00:00:00
abstract：:Chagas' disease is accompanied by severe anemia and oxidative stress, which may contribute to mortality. In this study, we investigated the role of 5-lipoxygenase (5-LO) in the control of parasitism and anemia associated with oxidative damage of erythrocytes in experimental Trypanosoma cruzi infection. Wild-type C57BL...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.02.002
更新日期：2009-03-24 00:00:00
abstract：BACKGROUND:CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.01.007
更新日期：2020-04-01 00:00:00
abstract：:Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00034-5
更新日期：1997-07-01 00:00:00
abstract：:Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90017-3
更新日期：1985-01-01 00:00:00
abstract：:The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytomet...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90126-0
更新日期：1989-12-01 00:00:00
abstract：:Two types of inhibition of basic peptide-induced rat mast cell secretion are reported. Pretreatment of rat peritoneal mast cells with Vibrio comma neuraminidase, an enzyme which cleaves sialic acid from oligosaccharides, led to inhibition of 5-hydroxytryptamine release induced by the basic peptides polylysine, cortico...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90134-1
更新日期：1982-10-01 00:00:00
abstract：:Based on the cerebral malaria coma scale, 39 falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups of patients that had either cerebral malaria or non-cerebral malaria. We then studied significant pathological differences, such as p...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90115-7
更新日期：1990-08-01 00:00:00
abstract：:The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90183-x
更新日期：1994-05-01 00:00:00
abstract：:Flt3 ligand, a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Its potential use in a clinical setting has been suggested. Here, we studied the effect of in situ delivery of Flt3 ligand plasmid (FL) on the antibody resp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00039-1
更新日期：2002-05-01 00:00:00
abstract：:CD27, which belongs to the TNF receptor family, is a costimulatory molecule that participates in T-cell activation. Unlike costimulatory molecules such as OX40 and 4-1BB, little is known about the role CD27 plays a role in the development of experimental diseases. We asked whether CD27 and its ligand CD70 participate ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.05.004
更新日期：2008-08-15 00:00:00
abstract：:Nervous and immune systems share specific recognition molecules for signals that originate in both systems. The information substances are polypeptides and their receptors. They comprise the multi-directional information exchange network whereby brain and nervous system function including mood and emotion can be integ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(87)90171-4
更新日期：1987-12-01 00:00:00
abstract：:CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.06.004
更新日期：2014-09-01 00:00:00
abstract：:Protozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.12.002
更新日期：2006-05-15 00:00:00
abstract：:The quasimonoclonal (QM) mouse provides a model to analyze B cell selection because major B cell antigen receptors (BCR) are composed of the knockin V(H)DJ(H) 17.2.25 (V(H)T) encoded H chain and the lambda1 or lambda2 L chain, thereby being specific for (4-hydoxy-3-nitrophenyl)acetyl (NP). We have reported that during...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.011
更新日期：2007-03-15 00:00:00
abstract：:The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.12.004
更新日期：2016-02-01 00:00:00
abstract：:Sequence-comparison indicates existing sequence-similarity between receptor-binding regions of human type 1 IFNs (IFN-alpha, -beta and -omega) and HIV-1 gp41. Previous findings had suggested that the increased levels of antibodies against human IFN-alpha and -beta in HIV-1-infected individuals are associated with a co...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00098-x
更新日期：1999-08-03 00:00:00
abstract：:Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90010-y
更新日期：1993-11-01 00:00:00
abstract：:Vogt-Koyanagi-Harada disease is an autoimmune systemic disorder. In Vogt-Koyanagi-Harada disease, inflammatory disorders occur in multiple organs containing melanocytes, including uvea (resulting in acute bilateral panuveitis), skin (resulting in vitiligo and alopecia), central nervous system (resulting in meningitis)...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00243-7
更新日期：2001-10-01 00:00:00
abstract：:Cultured T lymphocytes from pig blood can be activated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Activation is additive with that induced by the mitogenic lectin phytohaemagglutinin (PHA). Activation by TPA differs from that induced by PHA or other mitogenic lectins in that it is not inhibited e...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90063-9
更新日期：1983-01-01 00:00:00
