当前位置： SCI文献检索 > IMMUNOLOGY LETTERS期刊下所有文献 > Humoral immune response directed against LEDGF in patients with VKH.

Humoral immune response directed against LEDGF in patients with VKH.

Abstract：

:Vogt-Koyanagi-Harada disease is an autoimmune systemic disorder. In Vogt-Koyanagi-Harada disease, inflammatory disorders occur in multiple organs containing melanocytes, including uvea (resulting in acute bilateral panuveitis), skin (resulting in vitiligo and alopecia), central nervous system (resulting in meningitis) and inner ears (resulting in hearing loss and tinnitus). These inflammatory aspects are attributed to the destruction of melanocytes through immunological mechanisms. Studies have been carried out to elucidate the exact etiology and target autoantigen in Vogt-Koyanagi-Harada disease, but much remains to be investigated. Identification of target autoantigen is important to understand the etiology of autoimmune diseases, and for development of antigen-specific immuno-modulation therapy. To identify the target autoantigens in Vogt-Koyanagi-Harada disease, we made use of an immunoscreening of a bovine uveal cDNA expression library with serum samples obtained from patients with Vogt-Koyanagi-Harada disease. We identified an immunoreactive cDNA clone that encodes bovine lens epithelium derived growth factor. mRNA of human lens epithelium derived growth factor was determined by reverse transcription-polymerase chain reaction and it was expressed in human uvea, retina and melanocytes. Immunoglobulin G (IgG) autoantibodies were quantitated in an enzyme-linked immunosorbent assay, using recombinant human lens epithelium derived growth factor. The prevalence of IgG anti-lens epithelium derived growth factor autoantibodies in patients with Vogt-Koyanagi-Harada disease was significantly higher than that in healthy controls (66.7% versus 21.6%, P<0.001). On the other hand, the prevalence of the autoantibody in patients with panuveitis of other etiology, Behçet's disease and sarcoidosis, was almost same as that in healthy controls. These results suggest that the humoral immune response agonist lens epithelium derived growth factor is not a mere secondary phenomena caused by uveal tissue damage.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Yamada K,Senju S,Shinohara T,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

doi

10.1016/s0165-2478(01)00243-7

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

161-8

issue

3

eissn

0165-2478

issn

1879-0542

pii

S0165247801002437

journal_volume

78

pub_type

杂志文章

相关文献

IMMUNOLOGY LETTERS文献大全
  • Homeostatic and functional analysis of mature B cells in lambda5-deficient mice.

    abstract：:The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly r...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.05.013

    authors： Harfst E,Andersson J,Grawunder U,Ceredig R,Rolink AG

    更新日期：2005-11-15 00:00:00

  • Purification and characterization of lipopolysaccharide induced TNF-like factor from rabbit serum.

    abstract：:A TNF-like factor was purified from lipopolysaccharide (LPS) induced New Zealand white rabbit serum. The TNF-like factor was purified by DEAE-Sephacel, Sephacryl S-200, Mono-Q, CM-affi gel Blue, Superose 12 H/R preparative columns to the specific activity of 4 x 10(6) U/mg protein. The purified protein was 45 kDa in i...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(97)00134-x

    authors： Lee TH,Rhim TY,Son OK,Kim YH,Kim SS

    更新日期：1998-02-01 00:00:00

  • Antibodies against growth factor receptors can inhibit the proliferation of transformed cells via a cis-interaction with inhibitory FcR.

    abstract：:When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2012.02.007

    authors： Malbec O,Daëron M

    更新日期：2012-03-30 00:00:00

  • Interleukin-3 enhances cytokine production by LPS-stimulated macrophages.

    abstract：:In addition to its hematopoietic activities, interleukin-3 (IL-3) can modulate macrophage functions. We have studied the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor (TNF) by mouse peritoneal macrophages triggered by lipopolysaccharide (LPS) in the presence or absence of IL-3. Int...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(91)90109-n

    authors： Cohen L,David B,Cavaillon JM

    更新日期：1991-05-01 00:00:00

  • Characterization of a cytotoxic factor produced by rat bladder cancer cell line: its identity to TNF alpha.

    abstract：:Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)90051-5

    authors： Hojo H,Kaneko A,Nanya K,Kayagaki N,Hashimoto Y

    更新日期：1994-06-01 00:00:00

  • Proinflammatory status influences NK cells subsets in the elderly.

    abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2014.06.015

    authors： Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

    更新日期：2014-11-01 00:00:00

  • Are T cells from healthy heart really only passengers? Characterization of cardiac tissue T cells.

    abstract：:Numerous studies have dealt with occurrence of dendritic cells in various nonlymphoid organs such as kidney, liver or heart, whereas lymphocyte patterns in these organs have not been analyzed in detail. In the present study, leukocytes were quantified as cells/mm2 in the perivascular, interstitial and parenchymal tiss...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(96)02595-3

    authors： Holzinger C,Zuckermann A,Reinwald C,Imhof M,Schöllhammer A,Kramer G,Wolner E,Steiner G

    更新日期：1996-11-01 00:00:00

  • The involvement of multifunctional TGF-β and related cytokines in pathogenesis of endometriosis.

    abstract：PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2018.10.011

    authors： Sikora J,Smycz-Kubańska M,Mielczarek-Palacz A,Bednarek I,Kondera-Anasz Z

    更新日期：2018-09-01 00:00:00

  • In vitro sensitization using thymocyte conditioned medium prepared from fetal calf, horse and rabbit sera.

    abstract：:Thymocyte conditioned medium (TCM) was prepared using 2 lots of fetal calf, and 1 lot each of horse and rabbit sera. The 4 TCM and the respective sera alone were compared in their ability to support primary in vitro sensitization to sheep red blood cells (SRBC) as assayed by direct plaque formation. As would be expect...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(87)90084-8

    authors： White LL,Smith RA

    更新日期：1987-01-01 00:00:00

  • Historical overview on the morphological characterization of large granular lymphocytes/natural killer cells.

    abstract：:Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (o...

    journal_title：Immunology letters

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.imlet.2017.07.014

    authors： Ribatti D

    更新日期：2017-10-01 00:00:00

  • Anti-ovalbumin antibody binds to 3T3 cells and induces DNA synthesis.

    abstract：:Rabbit anti-ovalbumin antibodies were found to bind to Swiss NIH 3T3 fibroblasts by indirect immunofluorescence, and to induce DNA synthesis when these cells were arrested in G0 phase of their replicating cycle (G0-S activity). The proof that these effects were related to the ovalbumin paratopes is based on the follow...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(87)90069-1

    authors： Mangalo R,Doligez-Chambost A,Marcovich H

    更新日期：1987-05-01 00:00:00

  • Presentation of the Plasmodium falciparum antigen Pf155/RESA to human T cells. Variations in responsiveness induced by antigen presenting cells from different but MHC class II identical donors.

    abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)00163-4

    authors： Troye-Blomberg M,Lepers JP,Sjöberg K,Rahalimalala L,Larsson A,Olerup O,Perlmann P

    更新日期：1994-12-01 00:00:00

  • Infection with prevalent clinical strains of Mycobacterium tuberculosis leads to differential maturation of monocyte derived dendritic cells.

    abstract：:The link between innate and adaptive host immune response to Mycobacterium tuberculosis (M.tb) is driven by dendritic cells (DC). In this study, we examined the ability of prevalent clinical strains from south India (S7, S10) and laboratory strain H37Rv (Rv) to induce maturation of monocyte derived dendritic cells (Mo...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2008.01.009

    authors： Rajashree P,Das SD

    更新日期：2008-05-15 00:00:00

  • A monoclonal antibody demonstrating specificity for drug-resistance cells.

    abstract：:We have described a monoclonal antibody with specificity for permeability-altered drug-resistant cells. This gamma G2b antibody was characterized by antibody-mediated complement-dependent cytotoxicity and by immunofluorescence analysis using a flow cytometer-cell sorter. Further experiments with the flow cytometer sho...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(82)90084-0

    authors： O'Hara CJ,Price GB

    更新日期：1982-07-01 00:00:00

  • In vivo detection of lamellocytes in Drosophila melanogaster.

    abstract：:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...

    journal_title：Immunology letters

    pub_type： 信件

    doi：10.1016/j.imlet.2009.08.004

    authors： Honti V,Kurucz E,Csordás G,Laurinyecz B,Márkus R,Andó I

    更新日期：2009-09-22 00:00:00

  • The history of the controversial relationship between mast cells and basophils.

    abstract：:Work on mast cells and basophils began with their identification by Paul Ehrlich at the end of the 19th century. Mast cells and basophils were immediately perceived as closely linked cells and early nomenclature formulated by Ehrlich himself, i.e., tissue "Mastzellen" and blood "Mastzellen", reflected this unifying vi...

    journal_title：Immunology letters

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.imlet.2011.06.008

    authors： Crivellato E,Nico B,Ribatti D

    更新日期：2011-12-30 00:00:00

  • Safety and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs.

    abstract：:Classical swine fever (CSF) and pseudorabies (PR) are both major infectious diseases of pigs, causing enormous economic losses to the swine industry in many countries. A marker vaccine that enables differentiation of infected from vaccinated animals (DIVA) is highly desirable for control and eradication of these two d...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2016.04.014

    authors： Lei JL,Xia SL,Wang Y,Du M,Xiang GT,Cong X,Luo Y,Li LF,Zhang L,Yu J,Hu Y,Qiu HJ,Sun Y

    更新日期：2016-06-01 00:00:00

  • Activated T lymphocytes from patients with high risk of type I diabetes mellitus have different ability to produce interferon-gamma, interleukin-6 and interleukin-10 and undergo anti-CD95 induced apoptosis after insulin stimulation.

    abstract：:Type I Diabetes mellitus (DM1) is the effect of T cell dependent autoimmune destruction of insulin producing beta cells in the pancreas islet. T cells are activated in response to islet dominant autoantigens, the result being the development of DM1. Insulin is one of the islet autoantigens responsible for activation o...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(00)00309-6

    authors： Tchórzewski H,Głowacka E,Banasik M,Lewkowicz P,Szałapska-Zawodniak M

    更新日期：2001-01-15 00:00:00

  • A monoclonal antibody against the human IL-2 receptor binds to paraformaldehyde-fixed but not viable frog (Xenopus) splenocytes.

    abstract：:Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(90)90151-f

    authors： Haynes L,Moynihan JA,Cohen N

    更新日期：1990-12-01 00:00:00

  • Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.

    abstract：:In transplant rejection, graft versus host or autoimmune diseases T cells are mediating the pathophysiological processes. Compared to unspecific pharmacological immune suppression specific inhibition of those T cells, that are involved in the disease, would be an alternative and attractive approach. T cells are activa...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2009.06.002

    authors： Neumann F,Sturm C,Hülsmeyer M,Dauth N,Guillaume P,Luescher IF,Pfreundschuh M,Held G

    更新日期：2009-08-15 00:00:00

  • Association of MMP-9 gene polymorphisms with Behçet's disease risk.

    abstract：:The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to invest...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2015.01.005

    authors： Naouali A,Kaabachi W,Tizaoui K,Amor AB,Hamzaoui A,Hamzaoui K

    更新日期：2015-03-01 00:00:00

  • Piperlongumine alleviates lupus nephritis in MRL-Fas(lpr) mice by regulating the frequency of Th17 and regulatory T cells.

    abstract：:Recent data have shown that piperlongumine (PL), an important component of Piper longum fruits, is known to possess anti-inflammatory and vascular-protective activities. This study aimed to examine the therapeutic effects and underlying mechanisms of PL on lupus-prone MRL-Fas(lpr) mice. Female MRL-Fas(lpr) mice were i...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2014.05.001

    authors： Yao L,Chen HP,Ma Q

    更新日期：2014-09-01 00:00:00

  • Activation of T lymphocytes by 12-O-tetradecanoylphorbol-13-acetate is resistant to inhibition by cyclosporin A.

    abstract：:Cultured T lymphocytes from pig blood can be activated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Activation is additive with that induced by the mitogenic lectin phytohaemagglutinin (PHA). Activation by TPA differs from that induced by PHA or other mitogenic lectins in that it is not inhibited e...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(83)90063-9

    authors： Kay JE,Meehan RT,Benzie CR

    更新日期：1983-01-01 00:00:00

  • Impaired activation of mast cells upon IgE-mediated antigen stimulation in a stroke-prone spontaneously hypertensive rat strain, SHRSP.Z.

    abstract：:We investigated IgE-mediated allergic responses in a metabolic syndrome model rat strain, SHRSP.Z, which develops obesity and hypertension to cast light on the relationship between metabolic disturbances and allergic responses. IgE-mediated cutaneous anaphylactic responses were severely attenuated in this strain regar...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2009.11.007

    authors： Sakanaka M,Furuta K,Ichikawa A,Tanaka S

    更新日期：2010-01-18 00:00:00

  • Suppression of phagocytosis by adrenocorticotropic hormone in murine peritoneal macrophages.

    abstract：:Phagocytosis of latex beads by peritoneal macrophages was examined by means of flow cytometry (FCM). This assay revealed that adrenocorticotropic hormone (ACTH) suppressed phagocytosis in a dose-dependent manner. ACTH (1-24) was more suppressive than ACTH (1-39). Control phagocytosis was partially suppressed in Ca(2+)...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)90080-9

    authors： Ichinose M,Sawada M,Maeno T

    更新日期：1994-10-01 00:00:00

  • Down modulation of MHC surface molecules on B cells by suppressive immune complexes obtained from chronic intestinal schistosomiasis patients.

    abstract：:Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(98)00026-1

    authors： Rezende SA,Gollob KJ,Correa-Oliveira R,Goes AM

    更新日期：1998-06-01 00:00:00

  • Integration of activatory and inhibitory signals in human B-cells.

    abstract：:Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(96)02655-7

    authors： Sármay G,Koncz G,Gergely J

    更新日期：1996-12-01 00:00:00

  • MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis.

    abstract：:Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an effective immune response against TB, (ii) MyD88 is essential, but not because it transduces signals from TLRs, (iii) adaptive immunity...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2007.11.015

    authors： Reiling N,Ehlers S,Hölscher C

    更新日期：2008-02-15 00:00:00

  • WITHDRAWN: Communication between immune cells mediated by membrane connections.

    abstract：:This article has been withdrawn at the request of the authors and Guest Editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2009.09.015

    authors： Salter RD,Watkins SC

    更新日期：2009-10-04 00:00:00

  • A monoclonal antibody targeting the dimer interface of epidermal growth factor receptor (EGFR).

    abstract：:Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2016.10.011

    authors： Guo T,Zhao L,Zhang Y,Liu G,Yao Y,Li H

    更新日期：2016-12-01 00:00:00