Activation of T lymphocytes by 12-O-tetradecanoylphorbol-13-acetate is resistant to inhibition by cyclosporin A.

abstract：:Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...

journal_title：Immunology letters

authors： Ma Y,Liu X,Wei Z,Wang X,Xu D,Dai S,Li Y,Gao M,Ji C,Guo C,Zhang L,Wang X

更新日期：2014-11-01 00:00:00

abstract：:As a cytokine adjuvant, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been demonstrated to play central roles in the enhancement of the immune response and protection elicited by experimental vaccines. However, in our previous work, the co-administration of GM-CSF produced untoward effects on the immun...

journal_title：Immunology letters

authors： Chen H,Gao N,Wu J,Zheng X,Li J,Fan D,An J

更新日期：2014-11-01 00:00:00

abstract：:The link between innate and adaptive host immune response to Mycobacterium tuberculosis (M.tb) is driven by dendritic cells (DC). In this study, we examined the ability of prevalent clinical strains from south India (S7, S10) and laboratory strain H37Rv (Rv) to induce maturation of monocyte derived dendritic cells (Mo...

journal_title：Immunology letters

authors： Rajashree P,Das SD

更新日期：2008-05-15 00:00:00

abstract：:Recent data provide evidence that antigen-specific CD4+ T-cell clones or antigen-activated T-cell lines can kill antigen-presenting cells (APC). We focused our studies on monocytes acting as APC in cultures of T cells freshly isolated from peripheral blood. The presence of monocytes in culture was monitored by their a...

journal_title：Immunology letters

authors： Pryjma J,Zembala M,Baran J,Ernst M,Flad HD

更新日期：1995-06-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a chronic liver disease mediated by immunity, and could lead to liver fibrosis and hepatocellular carcinoma. However, the mechanisms for breaking hepatic tolerance and driving AIH still remain elusive. We herein reported that the non-specific liver inflammation triggered by carbon tetrach...

journal_title：Immunology letters

authors： Chi G,Pei JH,Ma QY,Ru YX,Feng ZH

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...

journal_title：Immunology letters

authors： Yen JH,Tsai WC,Chen CJ,Lin CH,Ou TT,Hu CJ,Liu HW

更新日期：2003-08-05 00:00:00

abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...

journal_title：Immunology letters

authors： Mbarik M,Kaabachi W,Henidi B,Sassi FH,Hamzaoui K

更新日期：2015-07-01 00:00:00

abstract：:ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...

journal_title：Immunology letters

authors： Gergely J,Pecht I,Sármay G

更新日期：1999-05-03 00:00:00

abstract：:When murine BALB/c splenocytes are pretreated for 2 h with different concentrations of 25-hydroxycholesterol (25-HC) or 7 beta-hydroxycholesterol (7-HC), washed and stimulated either with irradiated C57BL/6 splenocytes or with Con A, IL-2 secretion is inhibited in a dose-dependent way as well as the subsequent cell pr...

journal_title：Immunology letters

authors： Richert L,Beck JP,Shinitzky M

更新日期：1986-11-03 00:00:00

abstract：:It is widely known that mast cells and cytokine TNF-alpha are both involved in inflammatory reactions. Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. The experiments were performed in vitro on mast cells isolated from tissues by enzymatic dispe...

journal_title：Immunology letters

authors： Brzezińska-Błaszczyk E,Pietrzak A

更新日期：1997-12-01 00:00:00

abstract：:The cellular source of murine LAIF detected by an indirect leukocyte adherence inhibition (LAI) assay using capillary tubes was investigated using non-inducing peritoneal cells (PC) from normal and spindle-cell sarcoma-bearing A/J mice. Cell populations containing greater than 95% T-cells, B-cells or macrophages were ...

journal_title：Immunology letters

authors： Myers WL,O'Keefe ML,Gregory S

更新日期：1981-11-01 00:00:00

abstract：:In several diseases where the immune system plays an important role there has been a tremendous progress in treatment efficacy during the last decades. Based on necessary basic science these improvements are results of rapid, numerous and open-minded clinical trials where pieces of positive results step by step have b...

journal_title：Immunology letters

authors： Ludvigsson J

更新日期：2014-05-01 00:00:00

abstract：:The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...

journal_title：Immunology letters

authors： Stanton T,Maynard M

更新日期：1984-01-01 00:00:00

abstract：:The leukocyte common antigen, CD45, is one of the major glycoproteins on cells of hemopoietic origin showing considerable heterogeneity in both structure and expression. Biochemical heterogeneity has been attributed to differences in the primary sequence and glycosylation. In this paper we report an additional basis f...

journal_title：Immunology letters

authors： Oravecz T,Monostori E,Adrian O,Kurucz E,Andó I

更新日期：1994-04-01 00:00:00

abstract：:The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that...

journal_title：Immunology letters

authors： Inostroza-Nieves Y,Venkatraman P,Zavala-Ruiz Z

更新日期：2012-09-01 00:00:00

abstract：:Protozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are...

journal_title：Immunology letters

authors： Hernández MX,Barçante TA,Vilela L,Tafuri WL,Afonso LC,Vieira LQ

更新日期：2006-05-15 00:00:00

abstract：:Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre...

journal_title：Immunology letters

authors： Zav'yalov VP,Denesyuk AI

更新日期：1987-01-01 00:00:00

abstract：:Antibody-like molecules were formed by artificial recombination of proteolytic IgG fragments (Fab' with anti-SRBC activity, and Fc) and used for studies concerning the complement fixation. Such molecules, when composed of single Fab' bound to Fc fragment appeared inactive, while species containing two Fab' fragments r...

journal_title：Immunology letters

authors： Rybarska J,Konieczny L,Bobrzecka K,Laidler P

更新日期：1982-05-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) stimulates the development of monocytic features in human myeloid precursors. Because transcriptional regulation of IFN-gamma and the pituitary hormone prolactin (PRL) has been described to involve common Jak-STAT pathways, we addressed here the question of whether PRL plays a role in mono...

journal_title：Immunology letters

authors： Sedo A,Van Weyenbergh J,Rouillard D,Bauvois B

更新日期：1996-11-01 00:00:00

abstract：:CD8+CD28- regulatory T cells (Tregs) play important roles in chronic viral infections. Programmed death 1 (PD-1) is highly expressed on hepatitis C virus (HCV)-specific CTLs. However, little is known regarding the role of CD8+CD28-PD1+ T cells in hepatitis C. Herein, we found that the frequency of CD8+CD28-PD1+, but n...

journal_title：Immunology letters

authors： Wang W,Tong Z,Zhong J,Zhang L,Zhang H,Su Y,Gao B,Zhang C

更新日期：2018-10-01 00:00:00

abstract：:When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led ...

journal_title：Immunology letters

authors： Maurer PH,Liu DC,Grun JL

更新日期：1987-12-01 00:00:00

abstract：:Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an effective immune response against TB, (ii) MyD88 is essential, but not because it transduces signals from TLRs, (iii) adaptive immunity...

journal_title：Immunology letters

authors： Reiling N,Ehlers S,Hölscher C

更新日期：2008-02-15 00:00:00

abstract：:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...

journal_title：Immunology letters

authors： Kaslow DC,Kumar S

更新日期：1996-07-01 00:00:00

abstract：:A direct role for delayed hypersensitivity in organized granuloma formation has been emphasized in the literature, but some clinical and experimental studies have suggested a more complicated relationship. In order to further evaluate T-cell function in cutaneous granulomatous inflammation, hepatic granulomas isolated...

journal_title：Immunology letters

authors： Epstein WL,Okamoto M,Suya H,Fukuyama K

更新日期：1986-11-17 00:00:00

abstract：:Mice were exposed to restraint stress for 3h. During this period, low body temperature (hypothermia, 39 degrees C-->less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150 mg/dl-->up to 220 mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines incr...

journal_title：Immunology letters

authors： Watanabe M,Tomiyama-Miyaji C,Kainuma E,Inoue M,Kuwano Y,Ren H,Shen J,Abo T

更新日期：2008-01-15 00:00:00

abstract：:When IL-4 mRNA was distinguished from mRNA encoding its antagonist, the splice variant IL-4delta2, it was found to correlate directly with expression of TLR2 in fresh peripheral blood mononuclear cells (PBMCs) from normal donors (p=0.0013). Similarly IL-4 mRNA was high when TLR2 mRNA was abundant compared to levels of...

journal_title：Immunology letters

authors： Chang JS,Dheda K,Huggett JF,Kim LU,Zumla A,Rook GA

更新日期：2006-08-15 00:00:00

abstract：:CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...

journal_title：Immunology letters

authors： Bretz NP,Salnikov AV,Doberstein K,Garbi N,Kloess V,Joumaa S,Naumov I,Boon L,Moldenhauer G,Arber N,Altevogt P

更新日期：2014-09-01 00:00:00

abstract：:Forkhead box O1 (FoxO1) has a crucial role in the early B cell development. To understand the functional importance of FoxO1 gene in the early B cell expansion, we established a FoxO1 knockdown model using 70Z/3 pre-B cell line. The FoxO1 knockdown 70Z/3 cells (70Z/3-KD cells) showed the down-regulated expression of i...

journal_title：Immunology letters

authors： Li Z,Zhang N,Hui F,Zahid D,Zheng W,Xu X,Li W

更新日期：2019-12-01 00:00:00

abstract：:This paper describes a new murine monoclonal antibody, UN5, raised against human thymocytes. This antibody recognizes a molecule of approximately 45 kDa on thymocytes. Flow cytometric analysis reveals a high intensity of labeling with the majority of thymocytes, whereas only CD20+ cells from peripheral whole-blood sam...

journal_title：Immunology letters

authors： Tassone P,Bonelli P,Tuccillo F,Bond HM,Turco MC,Morrone G,Cecco L,Cerra M,Venuta S

更新日期：1994-02-01 00:00:00

abstract：:Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual va...

journal_title：Immunology letters

authors： Musset L,Ghillani P,Lunel F,Cacoub P,Cresta P,Frangeul L,Rosenheim M,Preud'homme JL

更新日期：1997-01-01 00:00:00