Abstract：
:The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to investigate the association of four single nucleotide polymorphisms (SNPs) in MMP-9 gene: -1562 C/T, 2003 G/A (R668Q), 836 A/G (Q279R) and 1721 C/G (R574P) with BD risk in the Tunisian population. The distribution of MMP-9 gene polymorphisms was analyzed by polymerase chain-reaction (PCR) and restriction fragment length polymorphism (RFLP) for 240 BD patients and 288 controls. Our study indicated that the MMP-9 -1562 C/T polymorphism (rs3918242) was not associated with BD risk. We found a significant association of the MMP-9 2003 G/A (rs17577) with an increased susceptibility to BD. However, the MMP-9 1721 C/G polymorphism (rs2250889) had a protective role against the development of BD. Subgroup analysis based on stratification by gender revealed that the MMP-9 2003 G/A polymorphism was associated with a highly significant BD risk in women's group (G vs. A: P=0.0000001). However, the MMP-9 836 A/G polymorphism had a protective role in men's group (G vs. A: P=0.00043). The MMP-9 1721 C/G polymorphism was associated with a protective effect in both men and women groups (CG+GG vs. CC: P=0.04 and P=0.0002, respectively). The haplotype analysis did not show any association with BD risk. A significant difference in the MMP-9 serum levels were observed in the patient subgroup with ocular lesions manifestations.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Naouali A,Kaabachi W,Tizaoui K,Amor AB,Hamzaoui A,Hamzaoui Kdoi
10.1016/j.imlet.2015.01.005subject
Has Abstractpub_date
2015-03-01 00:00:00pages
18-24issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(15)00006-1journal_volume
164pub_type
杂志文章abstract：:DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00235-8
更新日期：2001-09-03 00:00:00
abstract：:Murine peritoneal macrophages were isolated by adherence and their listericidal activity assessed in the presence or absence of selected cytokines. Untreated macrophages were not highly listericidal, showing moderate killing in the first 2 h after infection, and allowed progressive microbial growth thereafter (up to 9...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90158-7
更新日期：1991-03-01 00:00:00
abstract：:Recent data suggests that autoimmune factors play an important role in the pathogenesis of atherosclerosis. In this context several autoantigens have been shown to elicit an immune response that results in accelerated atherosclerotic plaque formation. In the present study, we investigated whether elevated titers of an...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00050-4
更新日期：1999-06-01 00:00:00
abstract：:Work on mast cells and basophils began with their identification by Paul Ehrlich at the end of the 19th century. Mast cells and basophils were immediately perceived as closely linked cells and early nomenclature formulated by Ehrlich himself, i.e., tissue "Mastzellen" and blood "Mastzellen", reflected this unifying vi...
journal_title：Immunology letters
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.imlet.2011.06.008
更新日期：2011-12-30 00:00:00
abstract：:RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While age...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.01.005
更新日期：2006-05-15 00:00:00
abstract：:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00085-j
更新日期：1995-07-01 00:00:00
abstract：:Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system (CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the CNS. In the initial phase of MS and its animal model, experimental autoimmune encephalomyelitis (EAE), peripheral macrophages infi...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.03.006
更新日期：2014-07-01 00:00:00
abstract：:Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis facto...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.11.001
更新日期：2018-09-01 00:00:00
abstract：:Neuraminidases act as a virulence factors for several pathogens that invade the human body through Peyer's patch M-cells. Because of the structural similarity of Aleuria aurantia lectin (AAL) to neuraminidases, we hypothesized that AAL might also target human M-cells. In an in vitro human M-cell co-culture model signi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.03.020
更新日期：2005-09-15 00:00:00
abstract：:Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.12.008
更新日期：2008-03-15 00:00:00
abstract：:NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signallin...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.02.009
更新日期：2020-05-01 00:00:00
abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.09.004
更新日期：2003-12-15 00:00:00
abstract：:Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cel...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.09.010
更新日期：2006-03-15 00:00:00
abstract：:This paper describes a new murine monoclonal antibody, UN5, raised against human thymocytes. This antibody recognizes a molecule of approximately 45 kDa on thymocytes. Flow cytometric analysis reveals a high intensity of labeling with the majority of thymocytes, whereas only CD20+ cells from peripheral whole-blood sam...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90098-1
更新日期：1994-02-01 00:00:00
abstract：:We describe the quantification of the absolute amounts of HLA class II mRNA and class II transactivator (CIITA) mRNA by competitive reverse transcription polymerase chain reaction in cultured synovial fibroblast-like cells (SFC) of patients with rheumatoid arthritis. High basal levels of transcription of class II mRNA...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)02712-0
更新日期：1997-06-01 00:00:00
abstract：:Indoleamine 2,3-dioxygenase (IDO) is an enzyme with an immunosuppressive effect whose function is diverted by tumor cells to counteract immune cell functions, inducing immune escape of tumor cells. The aim of this study was to investigate the clinical significance of IDO in nasopharyngeal carcinoma (NPC). Compared to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.11.012
更新日期：2016-01-01 00:00:00
abstract：:Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90037-3
更新日期：1984-01-01 00:00:00
abstract：:B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.09.019
更新日期：2011-01-30 00:00:00
abstract：:It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2004.08.018
更新日期：2005-01-31 00:00:00
abstract：:Cloned human T-cell lines were produced by limiting dilution of lymphocytes alloactivated in mixed leukocyte cultures, followed by expansion of clonal progeny with interleukin 2. Selected clones were analyzed for cell-mediated cytotoxicity (CTX) against a variety of targets susceptible or resistant to lytic attack by ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90044-x
更新日期：1982-05-01 00:00:00
abstract：:Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation. Inducive effect of ultraviolet (UV) has been indicated because of the enhanced expression of ADF/TRX in epidermal cells of...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00213-o
更新日期：1995-01-01 00:00:00
abstract：:Among tumor necrosis factor (TNF) superfamily, TNF-related apoptosis inducing ligand (TRAIL) along with TNF-alpha and FasL is known as death ligand due to its selective cytotoxicity against transformed tumor cells. TRAIL can also induce alternative angiogenic and/or proinflammatory signals other than apoptosis, howeve...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.01.010
更新日期：2008-05-15 00:00:00
abstract：:Phagolysis of apoptotic eosinophils plays an important role in the successful resolution of asthmatic inflammation. However, little is known about underlying mechanisms. Our aim is to investigate whether annexin I is involved in the dexamethasone-mediated enhancement of phagolysis of apoptotic eosinophils by A549 cell...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2007.06.002
更新日期：2007-08-15 00:00:00
abstract：:Multiple antigen peptides (MAP), consisting of a number of peptide copies synthesized on a branching lysyl core, offer a novel approach for rendering small peptides immunoreactive in solid-phase immunoassays. An octameric MAP, carrying 6 repeats of the sequence -N-A-A-G-, tandem repeated in the immunodominant region o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90092-o
更新日期：1991-09-01 00:00:00
abstract：:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00117-5
更新日期：1999-01-01 00:00:00
abstract：:Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90093-9
更新日期：1987-01-01 00:00:00
abstract：:Normal and tumor-bearing host (TBH) peritoneal macrophage (M phi) responses to in vitro lipopolysaccharide (LPS) treatment were measured by assessing functional and phenotypic changes. Both normal and TBH untreated M phi suppressed mixed lymphocyte reaction (MLR) reactivity at all concentrations. Normal host M phi tre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90031-k
更新日期：1990-03-01 00:00:00
abstract：:In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90095-x
更新日期：1981-04-01 00:00:00
abstract：:Proliferation of mouse lymph node lymphocytes in response to concanavalin A in serum-free medium is normally dependent upon the presence of transferrin. In the absence of transferrin, little proliferation occurred, but the response was restored by addition of the iron complex of pyridoxal isonicotinoyl hydrazone (FePI...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90071-x
更新日期：1987-05-01 00:00:00
abstract：:The present study was designed to investigate whether human equivalents of murine T helper cell subsets can be demonstrated by propagation of peripheral blood lymphocytes (PBL) with either recombinant human (rh) interleukin (IL) 2 or rhIL4 in the presence of neutralising antibodies. Cells of both cultures, termed T-IL...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90142-w
更新日期：1991-02-01 00:00:00
