Abstract:
:Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing human lymphoproliferative disease. CTL protection required a single dose of polyethylene-glycol-conjugated IL2. Mice were not protected by CTL that did not specifically recognize EBV-transformed B cells or by mitogen-activated lymphocytes.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Buchsbaum RJ,Fabry JA,Lieberman Jdoi
10.1016/0165-2478(96)02602-8subject
Has Abstractpub_date
1996-09-01 00:00:00pages
145-52issue
2-3eissn
0165-2478issn
1879-0542pii
0165-2478(96)02602-8journal_volume
52pub_type
杂志文章abstract::A major factor in the ability of the placenta to avoid allograft rejection is the differential expression of MHC class I antigens on its surface. Using monoclonal antibodies and the electron microscopic immunogold technique, we have demonstrated that only the pregnancy-associated (Pa) antigen, which carries a broadly ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90157-x
更新日期:1987-12-01 00:00:00
abstract::Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02655-7
更新日期:1996-12-01 00:00:00
abstract::Recently, a newly identified human HERV-K18 like endogenous retrovirus (IDDMK(1,2)22) has been associated to the etiology of type I diabetes (IDDM). Although the exact mechanism remains unclear, it was postulated that the 3' end ORF product of the env gene of IDDMK(1,2)22 would trigger a V beta 7-specific human T cell...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00340-6
更新日期:2002-04-01 00:00:00
abstract::Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.09.026
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.05.005
更新日期:2013-05-01 00:00:00
abstract::MHC tetramers are used to directly enumerate and visualize the antigen-specific T lymphocyte population of interest by flow cytometry, regardless of the T lymphocyte's functional capacity. Assay sensitivity can be hindered by non-specific binding activity, which is due to the inherent interactions of CD8 and MHC. Poin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.11.016
更新日期:2005-05-15 00:00:00
abstract::We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90035-o
更新日期:1990-03-01 00:00:00
abstract::The ability of immune checkpoint inhibitors (ICIs) to reactivate the killing function of the immune system to tumor cells has led to long lasting immune response presenting highly promising clinical advances. Recently, immune checkpoint inhibitors related resistance due to the specialized tumor microenvironment has al...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2019.03.006
更新日期:2020-04-01 00:00:00
abstract::Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90155-6
更新日期:1987-12-01 00:00:00
abstract::The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein expressed by rat mast cells and basophils. MAFA clustering by its specific monoclonal antibody, (mAb) G63, efficiently inhibits the FcvarepsilonRI induced secretory response of mucosal-type mast cells of the RBL-2H3 line, as well as b...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00013-5
更新日期:2002-06-03 00:00:00
abstract::The previously called "hemoglobinase" Sm32 molecule of the adult worm of Schistosoma mansoni was chemically synthesized in 22 polymeric peptides based on the t-boc strategy. Their immunogenicity was evaluated in rabbits to which a mixture of five to six peptides of 20 amino acids long were given in three doses with Fr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00086-5
更新日期:2003-09-08 00:00:00
abstract::Disease-modifying osteoarthritis (OA) therapy is not yet available. Several adjuvant therapies have demonstrated promising results in the treatment of OA. The present study aimed to investigate the therapeutic effects and underlying mechanisms of a combination of Lactobacillus acidophilus, vitamin B, and curcumin in t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.10.008
更新日期:2020-12-01 00:00:00
abstract::Cigarette smoke contains nicotine, an immunomodulatory component that is thought to affect immune surveillance and increase the progression of diseases. Dendritic cells (DCs) constitute a family of antigen-presenting (APCs) with inherent abilities to sense and translate environmental cues and to shape host immunity. W...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2007.02.005
更新日期:2007-04-15 00:00:00
abstract::Pulmonary intraparenchymal leukocytes were purified from normal mice. By flow cytometry, 20-30% of the lymphocytes were positive for the expression of Mac1, a cell-surface antigen largely restricted to macrophages, neutrophils and natural killer (NK) cells. Sorted Mac1+ lung lymphocytes were large and had abundant cyt...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00034-3
更新日期:1995-05-01 00:00:00
abstract::A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90194-f
更新日期:1991-07-01 00:00:00
abstract::A375 human melanoma cell cultures grown in the presence of TGF beta contained greatly reduced cell numbers and exhibited drastic alterations in cell morphology compared to the control cultures. Preincubation of the cells with the cytokine for only 18 h was sufficient to induce these changes irreversibly. Examination o...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90040-u
更新日期:1992-07-01 00:00:00
abstract::Work done in our laboratories, using a murine model, indicates that suppression of host immune responses might be due to secretion of soluble factors by tumor cells. The H238 cells (BALB/c embryonic fibroblasts transformed by UV-inactivated herpes simplex virus Type 2) exhibit progressive tumor growth with subsequent ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90087-q
更新日期:1991-09-01 00:00:00
abstract::DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00235-8
更新日期:2001-09-03 00:00:00
abstract:BACKGROUND:Vitamin D (vitD) is involved in important regulatory functions of the innate and adaptive immune system. So, it has been hypothesized that vitD might influence the course of atopic dermatitis (AD). Also obesity may have impact on immune system. The aim of our study was to investigate vitamin D status and bod...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.11.004
更新日期:2017-01-01 00:00:00
abstract::In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90067-z
更新日期:1990-02-01 00:00:00
abstract::Mice were exposed to restraint stress for 3h. During this period, low body temperature (hypothermia, 39 degrees C-->less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150 mg/dl-->up to 220 mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines incr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2007.09.010
更新日期:2008-01-15 00:00:00
abstract::The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00156-5
更新日期:2000-04-03 00:00:00
abstract::Secondary lymphoid organs (SLO) are crucial structures for immune-surveillance and rapid immune responses allowing resident lymphocytes to encounter antigen-presenting cells that carry antigens from peripheral tissues. These structures develop during embryonic life through a tightly regulated process that involves int...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2013.08.001
更新日期:2013-11-01 00:00:00
abstract::As shown earlier, the cells transformed in vitro by several different oncogenes, or spontaneously, during in vivo growth in normal hosts would be gradually replaced by the highly-tumorigenic descendants co-expressing high H2O2-catabolizing and PGE2-releasing activities. Acquisition of (H2O2(CA) + PGE(S)) phenotype pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00123-6
更新日期:1999-10-01 00:00:00
abstract::Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis facto...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.11.001
更新日期:2018-09-01 00:00:00
abstract::N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.06.005
更新日期:2016-09-01 00:00:00
abstract::Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2017.08.011
更新日期:2017-10-01 00:00:00
abstract::While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90091-f
更新日期:1993-02-01 00:00:00
abstract::The biological activity of six synthetic peptides of the 124-144 region of the human interferon alpha-2 (IFN alpha-2) molecule was studied. Peptides were examined for their ability to inhibit mitogen induced proliferation of human blood cells in vitro. Only the peptide corresponding to the amino acid sequence 124-138 ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90004-8
更新日期:1992-01-01 00:00:00
abstract::The cytotoxicity of natural killer (NK) and lymphokine activated killer (LAK) cells against two human bladder tumor cell lines (BT-A and BT-B) was investigated using a fluorometric assay by labeling tumor cell DNA with Hoechst dye No. 33342. Our results demonstrate that BT-A and BT-B cells have low sensitivity to the ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90150-9
更新日期:1991-03-01 00:00:00