Local administration of cyclosporin allows reduction of the dose prolonging survival of heart tissue allografts.


:In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts.


Immunol Lett


Immunology letters


Górecki D,Kruszewski A,Jakóbisiak M,Lasek W




Has Abstract


1990-02-01 00:00:00














  • Increased expression of C1-inhibitor mRNA in patients with hereditary angioedema treated with Danazol.

    abstract::The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Pappalardo E,Zingale LC,Cicardi M

    更新日期:2003-05-01 00:00:00

  • Molecular analysis of interleukin-10 gene polymorphisms in patients with Behçet's disease.

    abstract:BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...

    journal_title:Immunology letters

    pub_type: 临床试验,杂志文章


    authors: Afkari B,Babaloo Z,Dolati S,Khabazi A,Jadidi-Niaragh F,Talei M,Shanehbandi D,Mahmoudi S,Hazhirkarzar B,Sakhinia E

    更新日期:2018-02-01 00:00:00

  • The interactions of anti-MLI monoclonal antibodies with isoforms of the lectin from Viscum album.

    abstract::Monoclonal antibodies (mAb) reacting with native (TA5, TB12) and denatured (T33, T35) plant toxin mistletoe lectin I (MLI) from Viscum album have been obtained. The interaction between mAbs and native toxin with ML isoforms (MLII, MLIII) has been investigated. An immunological cross-reaction has been shown to take pla...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Tonevitsky AG,Rakhmanova VA,Agapov II,Shamshiev AT,Usacheva EA,Prokoph'ev SA,Denisenko ON,Alekseev YuO,Pfueller U

    更新日期:1995-01-01 00:00:00

  • Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes.

    abstract::Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Moriyama H,Yonehara S

    更新日期:2007-03-15 00:00:00

  • Simple screening of Bence-Jones proteins from unconcentrated urine.

    abstract::A rapid, sensitive and simple method is provided for detecting Bence-Jones proteins in unconcentrated urine by electrosyneresis. This is based on the fact that the free light-chains, similar to the intact immunoglobulin molecules, form complexes with albumin under the effect of glutaraldehyde. Consequently, the origin...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ottó S

    更新日期:1983-04-01 00:00:00

  • Hepatic phase of malaria is the target of cellular mechanisms induced by the previous and the subsequent stages. A crucial role for liver nonparenchymal cells.

    abstract::Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity ...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Mazier D,Rénia L,Nussler A,Pied S,Marussig M,Goma J,Grillot D,Miltgen F,Drapier JC,Corradin G

    更新日期:1990-08-01 00:00:00

  • Advanced age negatively influences mesenteric lymph node T cell responses after burn injury.

    abstract::While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Choudhry MA,Plackett TP,Schilling EM,Faunce DE,Gamelli RL,Kovacs EJ

    更新日期:2003-04-03 00:00:00

  • Nonspecific modification of cellular immunity by Yersinia enterocolitica.

    abstract::An isogenic pair of virulent and avirulent Yersinia enterocolitica O9 strains was used to examine the influence of the virulence plasmid on the non-specific modification of the cellular immunity in BALB/c mice after experimental infection with yersiniae. The modification of contact hypersensitivity response to dinitro...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ruiz-Bravo A,Jimenez-Valera M,Roman SM

    更新日期:1996-01-01 00:00:00

  • Pathological effect of IL-17A-producing TCRγδ(+) T cells in mouse genital mucosa against HSV-2 infection.

    abstract::Interleukin (IL)-17A is a cytokine that plays an important role in infectious, autoimmune, and inflammatory diseases. In this study, we found that TCRγδ(+)CD4(-)CD8(-) T cells, but not TCRαβ(+)CD4(+) T cells, are the primary producers of IL-17A in the genital tract of female mice in the steady-state condition. High mR...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kim JO,Cha HR,Kim ED,Kweon MN

    更新日期:2012-09-01 00:00:00

  • Antibodies against growth factor receptors can inhibit the proliferation of transformed cells via a cis-interaction with inhibitory FcR.

    abstract::When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Malbec O,Daëron M

    更新日期:2012-03-30 00:00:00

  • Eosinophil-mediated cellular cytotoxicity induced by zymosan-activated serum.

    abstract::The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: De Simone C,Ferrari M,Pugnaloni L,Ferrarelli G,Rumi C,Sorice F

    更新日期:1986-01-01 00:00:00

  • Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator.

    abstract::Proliferation of mouse lymph node lymphocytes in response to concanavalin A in serum-free medium is normally dependent upon the presence of transferrin. In the absence of transferrin, little proliferation occurred, but the response was restored by addition of the iron complex of pyridoxal isonicotinoyl hydrazone (FePI...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Brock JH,Stevenson J

    更新日期:1987-05-01 00:00:00

  • Deficient transformation of murine trisomy 16 fetal liver cells by the Abelson and J2 viruses.

    abstract::Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice conta...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Berger CN,Epstein CJ

    更新日期:1992-06-01 00:00:00

  • Electron microscopic localization of the Pa and RT1.Aa antigens on the placenta of the rat.

    abstract::A major factor in the ability of the placenta to avoid allograft rejection is the differential expression of MHC class I antigens on its surface. Using monoclonal antibodies and the electron microscopic immunogold technique, we have demonstrated that only the pregnancy-associated (Pa) antigen, which carries a broadly ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kanbour A,Macpherson TA,Kunz HW,Gill TJ 3rd

    更新日期:1987-12-01 00:00:00

  • Biomarkers for rheumatoid arthritis: From molecular processes to diagnostic applications-current concepts and future perspectives.

    abstract::Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Nakken B,Papp G,Bosnes V,Zeher M,Nagy G,Szodoray P

    更新日期:2017-09-01 00:00:00

  • Frequencies of epitope-specific cytotoxic T lymphocytes in active chronic viral hepatitis B infection by using MHC class I peptide tetramers.

    abstract::Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are thought to play key roles in viral control and liver damage. We have used HLA-A*02 tetramer complex to human HBV core 18-27 (Tc 18-27), envelope 183-191 (Te 183-191), envelope 335-343 (Te 335-343), and polymerase 575-583 (Tp 575-583) epitopes to chara...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Wu Y,Zhang J,Chen S,Chen A,Wang L,Li J,Zhao T,Zou L,Tang Y,Tingrong L,Wang F

    更新日期:2004-04-15 00:00:00

  • Antigen processing in earthworms.

    abstract::The administration of protein antigens into earthworms Lumbricus terrestris and Eisenia foetida induces the formation of antigen-binding protein (ABP) with the maximum response occurring between days 4 and 8. High proteolytic activities observed both in coelomocytes and in coelomic fluids cause rapid antigen degradati...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Tucková L,Bilej M

    更新日期:1994-07-01 00:00:00

  • Pneumococcal pneumonia suppresses allergy development but preserves respiratory tolerance in mice.

    abstract::Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hartmann C,Behrendt AK,Henken S,Wölbeling F,Maus UA,Hansen G

    更新日期:2015-03-01 00:00:00

  • Induction of FMLP-mediated calcium mobilization requires crosslinking of surface immunoglobulin in Daudi cells.

    abstract::We have explored the requirements for the induction of the N-formyl-methionyl-leucyl-phenylalanine (FMLP) response in Daudi cells after anti-immunoglobulin treatment. Our results indicate that (a) induction of responsiveness to FMLP was observed in Daudi only after crosslinking of surface immunoglobulin by anti-immuno...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kalunta CI,Kaptein JS,Scott SJ,Lin CK,Gu DG,Lad PM

    更新日期:1992-04-01 00:00:00

  • ELNKWA-epitope specific antibodies induced by epitope-vaccine recognize ELDKWA- and other two neutralizing-resistant mutated epitopes on HIV-1 gp41.

    abstract::Based on the fact that monoclonal antibody (mAb) 2F5 recognizing ELDKWA-epitope on HIV-1 gp41 separately or in combination with other mAbs showed potent neutralizing activity to a wide range of primary HIV-1 isolates in vivo and in vitro, but this epitope undergoes restricted mutation. ELNKWA is a neutralizing-resista...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Dong XN,Xiao Y,Chen YH

    更新日期:2001-01-01 00:00:00

  • Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv200(19), secreted from Saccharomyces cerevisiae.

    abstract::The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kaslow DC,Kumar S

    更新日期:1996-07-01 00:00:00

  • Decreased antibody-dependent and spontaneous cell-mediated cytotoxicity in patients with chronic renal failure.

    abstract::Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as c...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Láng I,Taraba I,Petrányi G

    更新日期:1981-11-01 00:00:00

  • Induction of apoptosis in bone marrow cells by gangliosides produced by a T cell lymphoma.

    abstract::The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Bharti AC,Singh SM

    更新日期:2000-04-03 00:00:00

  • Monoclonal antibodies and immune therapies for adult precursor B-acute lymphoblastic leukemia.

    abstract::Adult B-acute lymphoblastic leukemia (B-ALL) does not share the favorable prognosis seen in pediatric patients with the same disease. Less than 50% of patients experience long-term survival and for those adults over age 60, long-term survival is only 10%. At time of relapse, 5-year prognosis is a dismal 7%. Novel and ...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Sikaria S,Aldoss I,Akhtari M

    更新日期:2016-04-01 00:00:00

  • Protection against murine cysticercosis using cDNA expression library immunization.

    abstract::Genetic or DNA-based immunization, including genomic immunization, has shown to be a viable alternative approach to induce protective immunity against a number of pathogens in several disease models. Here we describe a new method, cDNA expression library immunization (cDELI), based on the use of a large number of cDNA...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Manoutcharian K,Terrazas LI,Gevorkian G,Govezensky T

    更新日期:1998-07-01 00:00:00

  • Isotype of antibodies responsible for immune lysis in Trypanosoma cruzi infected mice.

    abstract::Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Stefani MM,Takehara HA,Mota I

    更新日期:1983-01-01 00:00:00

  • Stromal cell-derived factor-1 production by spleen cells is affected by nitric oxide in protective immunity against blood-stage Plasmodium chabaudi CR in C57BL/6j mice.

    abstract::Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Garnica MR,Silva JS,de Andrade Junior HF

    更新日期:2003-10-31 00:00:00

  • Massive infiltration of basophilic cells in inflamed tissue after injection of RANTES.

    abstract::Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Conti P,Reale M,Barbacane RC,Frydas S,Felaco M,Grilli A,Placido FC,Cataldo I,Feliciani C,Di Gioacchino M,Anogianakis G,Dimitriadou D,Vacalis D,Trakatellis A

    更新日期:1997-07-01 00:00:00

  • Unusual "cytokine" activities of the random polymer (Glu60, Phe40) in murine immune systems.

    abstract::When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Maurer PH,Liu DC,Grun JL

    更新日期:1987-12-01 00:00:00

  • Anti-vascular endothelial growth factor receptor (VEGFR) 2 autoantibody identification in glioblastoma patient using single B cell-based antibody gene cloning.

    abstract::Antibody direct cloning from single B cells is simple and efficient and has been successful in antibody identification of infectious diseases. However, although a recent whole-exome sequencing revealed abundant heterogeneic mutation accumulation in cancers, identification and synthesis of autoantibodies against specif...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Iizuka A,Komiyama M,Oshita C,Kume A,Ashizawa T,Mitsuya K,Hayashi N,Nakasu Y,Yamaguchi K,Akiyama Y

    更新日期:2014-05-01 00:00:00