Abstract:
:Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity against pre-erythrocytic stages is clearly established. The potential interest of triggering peptide-primed CD4+ T cells has to be considered regarding protection. Indeed, CD4+ T cells induced by the non-repetitive part of the CS protein of Plasmodium yoelii are protective, by eliminating malaria from hepatocytes. The crucial role of the liver NPC has to be emphasized, their participation in TNF schizonticidal effect and in ADCC mechanisms being strongly supported by our data.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Mazier D,Rénia L,Nussler A,Pied S,Marussig M,Goma J,Grillot D,Miltgen F,Drapier JC,Corradin Gdoi
10.1016/0165-2478(90)90093-6subject
Has Abstract,Author List Incompletepub_date
1990-08-01 00:00:00pages
65-70issue
1-3eissn
0165-2478issn
1879-0542pii
0165-2478(90)90093-6journal_volume
25pub_type
杂志文章,评审abstract::CD70, the ligand of CD27, is a member of the TNF family, which includes molecules essential in the regulation of lymphocyte growth and survival. It is absent on resting lymphocytes but can be induced in vitro with activating stimuli. To extend information about its expression by different T-cell subpopulations, and it...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02693-4
更新日期:1997-02-01 00:00:00
abstract:AIM:To develop new approach for tumor immunotherapy with VEGFR2-based DNA vaccine. METHODS:VEGFR2 derived from different species were prepared by RT-PCR and subjected to recombinant constructs. The chimeric gene of VEGFR2 was prepared by integrating different epitopes in different species. By transfecting into cells, ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.07.013
更新日期:2009-09-22 00:00:00
abstract::The monocytic cell line I937 was derived from U937 by sorting for cells with high expression of MHC class II molecules. Further analysis of these class II molecules revealed the presence of the HLA-DR3 subtype suggesting that the cell line was a potential candidate for testing antigen presentation to T cells restricte...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)02478-6
更新日期:1996-01-01 00:00:00
abstract::Monoclonal antibodies (mAb) reacting with native (TA5, TB12) and denatured (T33, T35) plant toxin mistletoe lectin I (MLI) from Viscum album have been obtained. The interaction between mAbs and native toxin with ML isoforms (MLII, MLIII) has been investigated. An immunological cross-reaction has been shown to take pla...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)00181-p
更新日期:1995-01-01 00:00:00
abstract::Numerous studies have dealt with occurrence of dendritic cells in various nonlymphoid organs such as kidney, liver or heart, whereas lymphocyte patterns in these organs have not been analyzed in detail. In the present study, leukocytes were quantified as cells/mm2 in the perivascular, interstitial and parenchymal tiss...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02595-3
更新日期:1996-11-01 00:00:00
abstract::For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2013.07.004
更新日期:2013-06-01 00:00:00
abstract::A docile substrain of lymphocytic choriomeningitis virus (LCMV) causes a persistent infection in adult C3HeB mice and induces a severe autoimmune hemolytic anemia (AIHA) which is maximal around three weeks post infection (PI). Evaluations of serum immunoglobulin levels of these mice demonstrated grossly elevated IgG2a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90126-9
更新日期:1992-02-15 00:00:00
abstract::Retroplacental blood lymphocytes (RPL) obtained from women without complications at the term delivery were studied for proliferative response to mitogens and surface phenotype and were compared with autologous peripheral blood lymphocytes (PBL). Proliferation of RPL induced by phytohemagglutinin (PHA) was significantl...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90042-9
更新日期:1988-03-01 00:00:00
abstract::Phagocytosis of latex beads by peritoneal macrophages was examined by means of flow cytometry (FCM). This assay revealed that adrenocorticotropic hormone (ACTH) suppressed phagocytosis in a dose-dependent manner. ACTH (1-24) was more suppressive than ACTH (1-39). Control phagocytosis was partially suppressed in Ca(2+)...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90080-9
更新日期:1994-10-01 00:00:00
abstract::Forkhead box O1 (FoxO1) has a crucial role in the early B cell development. To understand the functional importance of FoxO1 gene in the early B cell expansion, we established a FoxO1 knockdown model using 70Z/3 pre-B cell line. The FoxO1 knockdown 70Z/3 cells (70Z/3-KD cells) showed the down-regulated expression of i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.09.004
更新日期:2019-12-01 00:00:00
abstract::The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90078-7
更新日期:1986-01-01 00:00:00
abstract::The aim of this work was to raise allotype specific monoclonal antibodies to human CD45, with the long-term objective of producing a reagent which could be used to prolong graft survival in renal transplantation through removal of passenger leukocytes from the graft. At present there are no anti-CD45 monoclonal antibo...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00056-5
更新日期:1999-06-01 00:00:00
abstract::A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90048-f
更新日期:1991-11-01 00:00:00
abstract::The effect of priming with various antigens on subsequent vaccination with the pneumococcal conjugate vaccine (CPV) was determined using BALB/c mice. Priming with pneumococcal polysaccharide or cross-reactive polysaccharide did not inhibit the IgG response to CPV immunization. Additionally, live intranasal colonizatio...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.04.013
更新日期:2006-08-15 00:00:00
abstract::Rabbit anti-ovalbumin antibodies were found to bind to Swiss NIH 3T3 fibroblasts by indirect immunofluorescence, and to induce DNA synthesis when these cells were arrested in G0 phase of their replicating cycle (G0-S activity). The proof that these effects were related to the ovalbumin paratopes is based on the follow...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90069-1
更新日期:1987-05-01 00:00:00
abstract::RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While age...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.01.005
更新日期:2006-05-15 00:00:00
abstract::Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90193-r
更新日期:1992-03-01 00:00:00
abstract::An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90175-7
更新日期:1988-08-01 00:00:00
abstract::Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.12.003
更新日期:2005-05-15 00:00:00
abstract::Normal and tumor-bearing host (TBH) peritoneal macrophage (M phi) responses to in vitro lipopolysaccharide (LPS) treatment were measured by assessing functional and phenotypic changes. Both normal and TBH untreated M phi suppressed mixed lymphocyte reaction (MLR) reactivity at all concentrations. Normal host M phi tre...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90031-k
更新日期:1990-03-01 00:00:00
abstract::A direct correlation between the constitutive expression of IL-1 alpha and reduced tumorigenicity of fibrosarcomas was observed. This was established in fibrosarcoma cell lines which produce IL-1 alpha 'spontaneously', possibly as an aberration of oncogene-mediated transformation or upon IL-1 alpha gene transfer. In f...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(93)90163-v
更新日期:1993-12-01 00:00:00
abstract::We describe the quantification of the absolute amounts of HLA class II mRNA and class II transactivator (CIITA) mRNA by competitive reverse transcription polymerase chain reaction in cultured synovial fibroblast-like cells (SFC) of patients with rheumatoid arthritis. High basal levels of transcription of class II mRNA...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)02712-0
更新日期:1997-06-01 00:00:00
abstract::The leukocyte common antigen, CD45, is one of the major glycoproteins on cells of hemopoietic origin showing considerable heterogeneity in both structure and expression. Biochemical heterogeneity has been attributed to differences in the primary sequence and glycosylation. In this paper we report an additional basis f...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90198-8
更新日期:1994-04-01 00:00:00
abstract::Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.imlet.2019.03.003
更新日期:2019-09-01 00:00:00
abstract::A considerable body of evidence from various laboratories indicates that specific T cell responses generated during infection with Leishmania parasites play an important role both in the resolution and progression of cutaneous leishmaniasis. Recent data, summarized in this article, indicate that resolution of lesions ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90151-4
更新日期:1988-11-01 00:00:00
abstract::Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.11.002
更新日期:2010-01-18 00:00:00
abstract::Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the presen...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.03.012
更新日期:2018-06-01 00:00:00
abstract::Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.05.002
更新日期:2013-05-01 00:00:00
abstract::Screening of expression cDNA libraries derived from human neoplasms with autologous sera (SEREX) is an established method for defining antigens immunogenic in individual cancer patients. Although the majority of SEREX-derived cDNA clones encode autoantigens, some of them represent shared cancer antigens with cancer-re...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00209-2
更新日期:2003-01-02 00:00:00
abstract::Much evidence indicates that atherosclerotic lesions are largely of an inflammatory nature. Activated macrophages and macrophage-derived foam cells laden with cholesterol esters are a major constituent of these lesions and can influence lesion formation via several potential mechanisms. One such mechanism is Fcgamma r...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00217-6
更新日期:2001-07-02 00:00:00