Abstract:
:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-specific Abs. Although HIV-specific and HLA allo-type specific Abs induced only weak CML of HIV primary isolates, several combinations of HLA allo-type specific Abs with HIV-specific Abs could enhance CML significantly. Nevertheless, certain HLA-specific Abs did not improve but even inhibit CML of HIV, although the corresponding HLA molecules were present. Thus, our results emphasize a possible limitation of allo-immunization as a potential approach to induce protective immunity against HIV.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Hildgartner A,Wilflingseder D,Gassner C,Dierich MP,Stoiber H,Bánki Zdoi
10.1016/j.imlet.2009.08.005subject
Has Abstractpub_date
2009-09-22 00:00:00pages
85-90issue
1-2eissn
0165-2478issn
1879-0542pii
S0165-2478(09)00209-0journal_volume
126pub_type
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