当前位置： SCI文献检索 > IMMUNOLOGY LETTERS期刊下所有文献 > Blood cell gene expression profiling in rheumatoid arthritis. Discriminative genes and effect of rheumatoid factor.

Blood cell gene expression profiling in rheumatoid arthritis. Discriminative genes and effect of rheumatoid factor.

Abstract：

UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and seven healthy controls. Gene expression of about 10,000 genes were examined using oligonucleotide-based DNA chip microarrays. The analyses showed no significant differences in PBMC expression patterns from RF-positive and RF-negative patients. However, comparisons of gene expression patterns from all fourteen RA patients and healthy controls identified a subset of discriminative genes. These results were validated by real time reverse transcription polymerase chain reaction (RT-PCR) on another group of RA patients and healthy controls. This confirmed that the following genes had a significantly higher expression in RA patients than in healthy controls: CD14 antigen, defensin alpha-1 and alpha-3 (DEFA), fatty-acid-Coenzyme A ligase, long-chain 2 (FACL), ribonuclease 2 (RNASE2), S100 calcium-binding protein A8 and A12 (S100A8 and S100A12). In contrast, the expression of MHC class II, DQ beta1 (HLA-DQB1) was significantly reduced in RA patients compared to healthy controls. CONCLUSIONS:With the analytical procedure employed, we did not find any indication that RF-positive and RF-negative RA are two fundamentally different diseases. Most of the genes discriminative between RA patients and healthy individuals are known to be involved in immunoinflammatory responses, especially those related to altered phagocytic functions.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Bovin LF,Rieneck K,Workman C,Nielsen H,Sørensen SF,Skjødt H,Florescu A,Brunak S,Bendtzen K

doi

10.1016/j.imlet.2004.03.018

subject

Has Abstract

pub_date

2004-05-15 00:00:00

pages

217-26

issue

2-3

eissn

0165-2478

issn

1879-0542

pii

S0165247804000872

journal_volume

93

pub_type

杂志文章

相关文献

IMMUNOLOGY LETTERS文献大全
  • T cell reactivity of defined peptides from a major Plasmodium falciparum vaccine candidate: the Pf155/RESA antigen.

    abstract：:Several immunodominant B-cell epitopes of the P. falciparum antigen blood stage Pf155/RESA, a major vaccine candidate antigen, are located in the molecular regions containing amino acid repeats. We started to map Pf155/RESA for T cell reactive epitopes. For this purpose, short synthetic peptides corresponding to the 3...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(88)90147-2

    authors： Troye-Blomberg M,Kabilan L,Riley EM,Ortlund J,Andersson G,Perlmann H,Olerup O,Högh B,Petersen E,Snow RW

    更新日期：1988-11-01 00:00:00

  • Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G.

    abstract：:A monoclonal human rheumatoid factor (RF-AN) reactive with human Fc gamma is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having C gamma 2 or C gamma 3 domain deletions or IgG3m (5) or Ig3m (21) proteins having argi...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(84)90042-7

    authors： Jefferis R,Nik Jaafar MI,Steinitz M

    更新日期：1984-01-01 00:00:00

  • Distinct cell death markers identified in critical care patient survivors diagnosed with sepsis.

    abstract：:Sepsis is an abnormal immune response to infection characterized by an overwhelming systemic inflammation and cell death. Non-apoptotic cell death pertaining to pyroptosis, necroptosis and autophagy contribute to sepsis pathogenesis apart from classical apoptotic cell death. The objective of the current study is to in...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2020.12.009

    authors： Mallarpu CS,Ponnana M,Prasad S,Singarapu M,Kim J,Haririparsa N,Bratic N,Brar H,Chelluri LK,Madiraju C

    更新日期：2021-01-03 00:00:00

  • Dendritic cells in germ-free and specific pathogen-free mice have similar phenotypes and in vitro antigen presenting function.

    abstract：:Dendritic cells (DC) can direct downstream T-cell responses. Although bacterial adjuvants are strong activators of DC in vitro, the effects of normal enteric bacteria on DC in vivo are not well defined. We used germ-free (GF) mice to determine whether enteric bacteria alter DC phenotype and ability to stimulate naïve ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.07.001

    authors： Walton KL,He J,Kelsall BL,Sartor RB,Fisher NC

    更新日期：2006-01-15 00:00:00

  • Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine.

    abstract：:HIV-1 positive patients generate Nef-specific CTL response, indicating that Nef is a potent immunogen. However, Nef is also known to down regulate the expression of CD4 and MHC-I molecules, thereby protecting virally infected target cells. We compared the immunogenicity of non-functional nef vaccine constructs to wild...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(03)00141-x

    authors： Majumder B,Gray B,McBurney S,Schaefer TM,Dentchev T,Mahalingam S,Reinhart TA,Ayyavoo V

    更新日期：2003-10-31 00:00:00

  • Two screening methods show different antigen recognition patterns for four monoclonal antibodies to Candida albicans cell surface.

    abstract：:Four murine monoclonal antibodies (mAbs) showing similar reactivity with a cell-wall extract and mannan preparation obtained from Candida albicans were examined for epitope specificity. An enzyme-linked immunosorbent assay (ELISA) was used to determine total mAb binding to extracted cell-wall antigen when each mAb was...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(89)90134-x

    authors： Chaffin WL,Morrow KJ Jr

    更新日期：1989-07-01 00:00:00

  • Interaction between serum amyloid A and leukocytes - a possible role in the progression of vascular complications in diabetes.

    abstract：:Diabetes mellitus is associated with an increased incidence of cardiovascular events and microvascular complications. Serum amyloid A (SAA), a HDL apolipoprotein is a risk marker for cardiovascular disease. A permanent increase in SAA plasma levels is observed in diabetics. Because SAA acts on leukocytes, we evaluated...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2006.12.005

    authors： Hatanaka E,Monteagudo PT,Marrocos MS,Campa A

    更新日期：2007-02-15 00:00:00

  • Pharmacological targeting of immune checkpoint A2aR improves function of anti-CD19 CAR T cells in vitro.

    abstract：:In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2020.04.005

    authors： Fallah-Mehrjardi K,Mirzaei HR,Masoumi E,Jafarzadeh L,Rostamian H,Khakpoor-Koosheh M,Alishah K,Noorbakhsh F,Hadjati J

    更新日期：2020-07-01 00:00:00

  • Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways.

    abstract：:Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.10.020

    authors： Cho ML,Jung YO,Moon YM,Min SY,Yoon CH,Lee SH,Park SH,Cho CS,Jue DM,Kim HY

    更新日期：2006-03-15 00:00:00

  • Cytokine-deficient mice as a model for generation of autologous anti-cytokine monoclonal antibodies.

    abstract：:The possibility of inducing immune responses to murine interleukin-4 (IL-4) and IL-13 and generating anti-cytokine monoclonal antibodies (mAbs) was studied in IL-4- and IL-13-knockout mice. The minimal doses of IL-4 or IL-13 that could induce significant anti-cytokine responses with titers of 5000-10,000 were 20 micro...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.08.005

    authors： Shichkin VP,Spivak NY

    更新日期：2006-02-15 00:00:00

  • Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells.

    abstract：:Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation. Inducive effect of ultraviolet (UV) has been indicated because of the enhanced expression of ADF/TRX in epidermal cells of...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(95)00213-o

    authors： Sachi Y,Hirota K,Masutani H,Toda K,Okamoto T,Takigawa M,Yodoi J

    更新日期：1995-01-01 00:00:00

  • Apoptosis and oxidative burst in neutrophils infected with Mycobacterium spp.

    abstract：:Two of the better characterized antimicrobial mechanisms displayed by human neutrophils are the reactive oxygen species (ROS) production and the induction of apoptosis. Their importance in mycobacterial infections is, however, controversial and we aimed to analyze them simultaneously in neutrophils infected with eithe...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2009.07.006

    authors： González-Cortés C,Reyes-Ruvalcaba D,Diez-Tascón C,Rivero-Lezcano OM

    更新日期：2009-09-22 00:00:00

  • Plasma levels of sTNFR p75 and IL-8 in patients with HIV-1 infection.

    abstract：:We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may refl...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(96)02583-7

    authors： Hober D,Benyoucef S,Delannoy AS,De Groote D,Ajana F,Mouton Y,Wattré P

    更新日期：1996-08-01 00:00:00

  • Selective induction of CD8+CD4- thymocyte apoptosis mediated by the B-subunit of Escherichia coli heat-labile enterotoxin.

    abstract：:Receptor-binding by the B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) induces apoptosis of peripheral CD8(+), but not CD4(+) T-cells. Given that peripheral CD8(+) and CD4(+) T cells arise from a common developmental pathway in the thymus, we investigated the effects of EtxB on different thymocyte popula...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(03)00049-x

    authors： Salmond RJ,Williams R,Hirst TR,Williams NA

    更新日期：2003-07-03 00:00:00

  • Use of antibody gene library for the isolation of specific single chain antibodies by ampicillin-antigen conjugates.

    abstract：:Isolation of recombinant antibodies from antibody libraries is commonly performed by different molecular display formats including phage display and ribosome display or different cell-surface display formats. We describe a new method which allows the selection of Escherichia coli cells producing the required single ch...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.02.005

    authors： Neumann-Schaal M,Messerschmidt K,Grenz N,Heilmann K

    更新日期：2013-03-01 00:00:00

  • LMP-1, the Epstein-Barr virus-encoded oncogene with a B cell activating mechanism similar to CD40.

    abstract：:Many details in the expression pattern of Epstein-Barr virus (EBV)-encoded proteins, their role in blast and growth transformation in infected B lymphocytes are known, but 'black holes' still exist. The two main types of virus-B lymphocyte interactions are denoted as Type I and Type III. These are characterized by the...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-2478(99)00044-9

    authors： Klein E,Teramoto N,Gogolák P,Nagy N,Björkholm M

    更新日期：1999-05-03 00:00:00

  • Phosphatidylinositol metabolism in lymphocytes of chronic alcoholic patients after anti-CD3 stimulation.

    abstract：:The immunological alterations observed in chronic alcoholic patients may be due to alterations of signal transduction across the lymphocyte membrane. Upon binding of mitogens or antigens to specific plasma membrane receptors, the activation of phospholipase C leads to the hydrolysis of inositol phospholipids, producin...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(95)00019-2

    authors： Hrelia S,Celadon M,Bordoni A,Castelli E,Foschi FG,Stefanini GF,Rossi CA,Biagi PL

    更新日期：1995-05-01 00:00:00

  • Innate lymphoid cells, precursors and plasticity.

    abstract：:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2016.07.004

    authors： Gronke K,Kofoed-Nielsen M,Diefenbach A

    更新日期：2016-11-01 00:00:00

  • IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1.

    abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2008.11.001

    authors： Hadjur S,Bruno L,Hertweck A,Cobb BS,Taylor B,Fisher AG,Merkenschlager M

    更新日期：2009-01-29 00:00:00

  • The role of autoantigen in autoimmunity.

    abstract：:Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(87)90155-6

    authors： Roitt IM,Cooke A

    更新日期：1987-12-01 00:00:00

  • Human endogenous retrovirus IDDMK(1,2)22 and mouse mammary tumor virus superantigens differ in their ability to stimulate murine T cell hybridomas.

    abstract：:Recently, a newly identified human HERV-K18 like endogenous retrovirus (IDDMK(1,2)22) has been associated to the etiology of type I diabetes (IDDM). Although the exact mechanism remains unclear, it was postulated that the 3' end ORF product of the env gene of IDDMK(1,2)22 would trigger a V beta 7-specific human T cell...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(01)00340-6

    authors： Azar GA,Thibodeau J

    更新日期：2002-04-01 00:00:00

  • Granzyme B-expressing treg cells are enriched in colorectal cancer and present the potential to eliminate autologous T conventional cells.

    abstract：:In addition to expressing inhibitory cytokines and suppressive molecules, Treg cells could downplay inflammation by releasing cytotoxic molecules and eliminating proinflammatory immune cells. Colorectal cancer (CRC) is a common malignancy that has led to many cancer-related deaths. In this study, we investigated the c...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2019.10.007

    authors： Sun B,Liu M,Cui M,Li T

    更新日期：2020-01-01 00:00:00

  • Human T cell subsets differ in their ability to migrate in vitro and to produce T cell migration inhibitory factor.

    abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90122-7

    authors： Kowalczyk D,Pryjma J,Zembala M

    更新日期：1986-08-01 00:00:00

  • Infection with prevalent clinical strains of Mycobacterium tuberculosis leads to differential maturation of monocyte derived dendritic cells.

    abstract：:The link between innate and adaptive host immune response to Mycobacterium tuberculosis (M.tb) is driven by dendritic cells (DC). In this study, we examined the ability of prevalent clinical strains from south India (S7, S10) and laboratory strain H37Rv (Rv) to induce maturation of monocyte derived dendritic cells (Mo...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2008.01.009

    authors： Rajashree P,Das SD

    更新日期：2008-05-15 00:00:00

  • Genetic regulation of macrophage priming/activation: the Lsh gene story.

    abstract：:This paper describes functional and genetic studies on the macrophage resistance gene Lsh/Ity/Bcg first described almost two decades ago. Working in vitro with resident peritoneal, liver (Kupffer cells) and bone marrow derived macrophages from congenic B10 (LshS) and B10.L-LshR mice it has been possible to demonstrate...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0165-2478(91)90032-6

    authors： Blackwell JM,Roach TI,Atkinson SE,Ajioka JW,Barton CH,Shaw MA

    更新日期：1991-10-01 00:00:00

  • Up-regulation of IL-10 expression in dendritic cells is involved in Trichosanthin-induced immunosuppression.

    abstract：:We report here that Trichosanthin (Tk), a primary active component isolated from a Chinese traditional medicinal herb, Trichosanthes kirilowii, potently inhibits lymphocyte proliferative response in vitro. We found that Tk treatment increased production of the interleukins IL-4 and IL-10, while production of IL-2 and ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2007.03.008

    authors： Zhou X,Yang N,Lu L,Ding Q,Jiao Z,Zhou Y,Chou KY

    更新日期：2007-05-15 00:00:00

  • Circulating CXCR3-CCR6-CXCR5+CD4+ T cells are associated with acute allograft rejection in liver transplantation.

    abstract：:Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...

    journal_title：Immunology letters

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.imlet.2019.03.003

    authors： Zhang K,Sun YL,Zhou SN,Xu RN,Liu ZW,Wang FS,Shi M

    更新日期：2019-09-01 00:00:00

  • Recombinant interleukin-2 inhibits growth of human tumor xenografts in congenitally athymic mice.

    abstract：:Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(87)90013-7

    authors： Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová E

    更新日期：1987-04-01 00:00:00

  • Human T-cell leukemia virus-associated nuclear antigen (HTLV-NA).

    abstract：:Replication-competent retroviruses are not known to encode or induce nuclear antigens that are immunogenic in their natural hosts. We describe here the detection of a human T-lymphotropic virus (type I and type II) associated nuclear antigen (HTLV-NA) by an anticomplement immunofluorescence assay. Antibody to HTLV-NA ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90120-3

    authors： Lee TH,Essex M,Klein E,Klein G

    更新日期：1986-08-01 00:00:00

  • The use of Fab-Fc recombinant antibodies for studying the mechanism of triggering the effector activities of immunoglobulins.

    abstract：:Immunoglobulin species, recombined from Fab and Fc fragments with anti-red cell specificity were used as cytophilic antibodies in studies of triggering the effector activity of immunoglobulins. Recombinant immunoglobulins containing a single Fab' appeared inactive in binding to cell receptors and triggering antibody d...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(84)90046-4

    authors： Uracz W,Bobrzecka K,Konieczny L,Rybarska J,Zembala M

    更新日期：1984-01-01 00:00:00