Abstract：
:Several immunodominant B-cell epitopes of the P. falciparum antigen blood stage Pf155/RESA, a major vaccine candidate antigen, are located in the molecular regions containing amino acid repeats. We started to map Pf155/RESA for T cell reactive epitopes. For this purpose, short synthetic peptides corresponding to the 3'- and 5' repeat regions of the molecule as well as to non-repeated sequences outside these regions were prepared. T cells from P. falciparum primed donors from two highly endemic areas of Africa were tested for their responsiveness to the peptides by thymidine incorporation and/or interferon gamma (IFN-gamma) release. There was a considerable variation in the response to the different peptides. However, the strongest and most frequent responses were seen with a few peptides from the 3'- and 5'-repeat regions. Thus, the immunodominant B cell epitope regions of Pf155/RESA, contain several T cell epitopes. Since the repeat regions are known to be conserved in different P. falciparum strains, the T cell epitopes reported here may be suitable constituents of a P. falciparum subunit vaccine.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Troye-Blomberg M,Kabilan L,Riley EM,Ortlund J,Andersson G,Perlmann H,Olerup O,Högh B,Petersen E,Snow RWdoi
10.1016/0165-2478(88)90147-2subject
Has Abstract,Author List Incompletepub_date
1988-11-01 00:00:00pages
229-33issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(88)90147-2journal_volume
19pub_type
杂志文章abstract：:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90056-7
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更新日期：2007-01-15 00:00:00
abstract：:T and B cell receptor repertoires are diversified by variable region gene rearrangement and selected based on functionality and lack of self-reactivity. Repertoires can also be defined based on phenotype and function rather than receptor specificity - such as the diversity of T helper cell subsets. Natural killer (NK)...
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abstract：:The cell-surface glycoproteins encoded by the major histocompatibility complex (MHC) bind to processed foreign antigens and present them to T lymphocytes. Two classes of MHC molecules and their corresponding gene sequences have been extensively studied in eutherian mammals and birds, but data on the marsupial MHC are ...
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pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00314-x
更新日期：2001-02-01 00:00:00
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journal_title：Immunology letters
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doi：10.1016/j.imlet.2008.07.005
更新日期：2008-10-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00143-1
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：1991-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2011-08-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-2478(82)90070-0
更新日期：1982-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(88)90001-6
更新日期：1988-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2004.04.015
更新日期：2004-06-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)02455-7
更新日期：1995-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.04.016
更新日期：2017-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90003-3
更新日期：1985-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90069-1
更新日期：1987-05-01 00:00:00
abstract：:The effect of B cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. Thirteen CBA mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse Ig antibody from 24 hours to 8 weeks after birth. Controls were given normal rabbit IgG (...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90063-1
更新日期：1989-01-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90051-5
更新日期：1994-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90003-1
更新日期：1981-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90056-3
更新日期：1987-10-01 00:00:00
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更新日期：1997-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1990-09-01 00:00:00
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更新日期：2003-02-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90103-9
更新日期：1987-02-01 00:00:00
abstract：:Screening of expression cDNA libraries derived from human neoplasms with autologous sera (SEREX) is an established method for defining antigens immunogenic in individual cancer patients. Although the majority of SEREX-derived cDNA clones encode autoantigens, some of them represent shared cancer antigens with cancer-re...
journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2003-01-02 00:00:00
abstract：:Cellular membranes contain microdomains known as 'lipid rafts' or detergent-insoluble microdomains (DRM), enriched in cholesterol and sphingolipids. DRM can play an important role in many cellular processes, including signal transduction, cytoskeletal organization, and pathogen entry. Many receptors like T cell recept...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2007.12.003
更新日期：2008-03-15 00:00:00
abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.09.004
更新日期：2003-12-15 00:00:00
abstract：:BAFF deficiency in mice impairs B cell development beyond the transitional stage 1 in the spleen and thus severely reduces the size of follicular and marginal zone B cell compartments. Moreover, humoral immune responses in these mice are dramatically impaired. We now addressed the question whether the decrease in matu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.03.007
更新日期：2010-06-15 00:00:00
abstract：:Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.009
更新日期：2007-03-15 00:00:00
