Decreased antibody-dependent and spontaneous cell-mediated cytotoxicity in patients with chronic renal failure.

Abstract:

:Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as compared to the corresponding mean values of healthy control persons and non-uremic patients with the same underlying diseases. The addition of autologous serum further reduced the impaired cytotoxic capacity of uremic lymphocytes. Uremic sera also inhibited the antibody-dependent and spontaneous lymphocytotoxicity of healthy individuals.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Láng I,Taraba I,Petrányi G

doi

10.1016/0165-2478(81)90003-1

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

267-71

issue

5

eissn

0165-2478

issn

1879-0542

pii

0165-2478(81)90003-1

journal_volume

3

pub_type

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