Abstract:
:Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as compared to the corresponding mean values of healthy control persons and non-uremic patients with the same underlying diseases. The addition of autologous serum further reduced the impaired cytotoxic capacity of uremic lymphocytes. Uremic sera also inhibited the antibody-dependent and spontaneous lymphocytotoxicity of healthy individuals.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Láng I,Taraba I,Petrányi Gdoi
10.1016/0165-2478(81)90003-1subject
Has Abstractpub_date
1981-11-01 00:00:00pages
267-71issue
5eissn
0165-2478issn
1879-0542pii
0165-2478(81)90003-1journal_volume
3pub_type
杂志文章abstract::Molecular chaperones (heat shock proteins, Hsp-s) play a pleiotropic role in immunological functions. Hsp-s participate in the presentation of peptide antigens, folding of several immunologically important proteins, such as the MHC, and in the maintenance of the activation-competent conformation of key signaling molec...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2003.11.025
更新日期:2004-03-29 00:00:00
abstract::The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytomet...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90126-0
更新日期:1989-12-01 00:00:00
abstract::The thymus contains a low frequency of B cells, about 0.1-0.5% of total population of thymocytes that were shown to contribute in thymic negative selection. The fact that B cells in the periphery have been contributed in the generation of the T regulatory cell compartment emerged the idea that this process may indeed ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.03.007
更新日期:2017-05-01 00:00:00
abstract::Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephe...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02522-9
更新日期:1996-05-01 00:00:00
abstract::Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90044-q
更新日期:1990-06-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.10.011
更新日期:2016-12-01 00:00:00
abstract::Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00026-1
更新日期:1998-06-01 00:00:00
abstract::Receptor-binding by the B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) induces apoptosis of peripheral CD8(+), but not CD4(+) T-cells. Given that peripheral CD8(+) and CD4(+) T cells arise from a common developmental pathway in the thymus, we investigated the effects of EtxB on different thymocyte popula...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00049-x
更新日期:2003-07-03 00:00:00
abstract::Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90086-1
更新日期:1987-01-01 00:00:00
abstract::In this study the effect of PHA activation on the phosphatase activity of CD45 has been investigated in human leukemic T-cell lines. It has been found that in vivo activation of the cells with PHA resulted in 2-4-fold increase in enzyme activity. Addition of PHA to the postnuclear supernatant of cell lysates also resu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90086-8
更新日期:1994-10-01 00:00:00
abstract::Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.09.004
更新日期:2003-12-15 00:00:00
abstract::Serum antibodies reactive with intermediate filaments of the cytoskeleton (anti-IF antibodies) are often present in infectious mononucleosis, some other viral diseases, and rheumatoid arthritis. The mechanism of their production is not known, but it is possible that the formation of this and other autoantibodies resul...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90135-3
更新日期:1982-10-01 00:00:00
abstract::Monoclonal antibodies (mAb) reacting with native (TA5, TB12) and denatured (T33, T35) plant toxin mistletoe lectin I (MLI) from Viscum album have been obtained. The interaction between mAbs and native toxin with ML isoforms (MLII, MLIII) has been investigated. An immunological cross-reaction has been shown to take pla...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)00181-p
更新日期:1995-01-01 00:00:00
abstract::IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releas...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.04.003
更新日期:2019-06-01 00:00:00
abstract::A survey of the appearance of natural antibodies in C57BL/6 mice, measured by a complement-dependent cytotoxicity test against syngeneic radiation leukemia virus-induced lymphoma, was performed. Activity could be detected in sera from 5- to 14-month-old animals. This activity could be attributed mainly to IgM antibodi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(81)90074-2
更新日期:1981-10-01 00:00:00
abstract::Autoimmune hepatitis (AIH) is a chronic liver disease mediated by immunity, and could lead to liver fibrosis and hepatocellular carcinoma. However, the mechanisms for breaking hepatic tolerance and driving AIH still remain elusive. We herein reported that the non-specific liver inflammation triggered by carbon tetrach...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.11.010
更新日期:2020-02-01 00:00:00
abstract::Work done in our laboratories, using a murine model, indicates that suppression of host immune responses might be due to secretion of soluble factors by tumor cells. The H238 cells (BALB/c embryonic fibroblasts transformed by UV-inactivated herpes simplex virus Type 2) exhibit progressive tumor growth with subsequent ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90087-q
更新日期:1991-09-01 00:00:00
abstract::Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2007.12.008
更新日期:2008-03-15 00:00:00
abstract::Homogeneous IgG fractions were obtained by chromatography of the sera of patients with multiple sclerosis (MS) on Protein G-Sepharose under conditions that remove non-specifically bound proteins. These IgGs contained several chelated metals, the relative amount of which decreases in the order: Fe>or=Ca>Cu>or=Zn>or=Mg>...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.10.018
更新日期:2006-02-28 00:00:00
abstract::Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (o...
journal_title:Immunology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.imlet.2017.07.014
更新日期:2017-10-01 00:00:00
abstract::The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...
journal_title:Immunology letters
pub_type: 信件
doi:10.1016/j.imlet.2008.06.002
更新日期:2008-08-15 00:00:00
abstract::Chagas' disease is accompanied by severe anemia and oxidative stress, which may contribute to mortality. In this study, we investigated the role of 5-lipoxygenase (5-LO) in the control of parasitism and anemia associated with oxidative damage of erythrocytes in experimental Trypanosoma cruzi infection. Wild-type C57BL...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.02.002
更新日期:2009-03-24 00:00:00
abstract::Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.01.006
更新日期:2020-04-01 00:00:00
abstract::This study tested the hypothesis that the Vδ3 subset of human γδ T cells, like their Vδ2 counterparts, can influence differentiation, antibody secretion and cytokine production by B cells. Vδ3 T cells constitute a minor subset of peripheral blood lymphocytes but are enriched in the liver and gut and are expanded in pa...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.02.002
更新日期:2018-04-01 00:00:00
abstract::Two chicken monoclonal antibodies (MAbs), HU/Ch2-7 and HU/Ch6-1, against heterophil Hanganutziu-Deicher (HD) antigens with N-glycolylneuraminic acid (NeuGc) at a terminal carbohydrate were established by cell fusions using chicken B cell lines lacking thymidine kinase and spleen cells from chickens immunized with II3N...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90205-3
更新日期:1992-03-01 00:00:00
abstract::Human milk lactotransferrin at a concentration ranging from 1 to 10 micrograms/ml stimulated up to 5 times the humoral immune response to sheep red blood cells, expressed as the number of plaque-forming cells, when injected into mice 3 h before immunization. Further, lactotransferrin-treated thymocytes given intraveno...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90099-v
更新日期:1991-09-01 00:00:00
abstract::Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.11.001
更新日期:2009-01-29 00:00:00
abstract::In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90213-t
更新日期:1991-07-01 00:00:00
abstract::Antibody direct cloning from single B cells is simple and efficient and has been successful in antibody identification of infectious diseases. However, although a recent whole-exome sequencing revealed abundant heterogeneic mutation accumulation in cancers, identification and synthesis of autoantibodies against specif...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.02.004
更新日期:2014-05-01 00:00:00
abstract::The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02570-9
更新日期:1996-07-01 00:00:00