当前位置： SCI文献检索 > IMMUNOLOGY LETTERS期刊下所有文献 > hsBAFF enhances activity of NK cells by regulation of CD4(+) T lymphocyte function.

hsBAFF enhances activity of NK cells by regulation of CD4(+) T lymphocyte function.

Abstract：

:B cell activating factor belonging to the TNF family (BAFF, also called BLyS, TALL-1, THANK, or zTNF4) is an important survival factor for B cells, and is able to regulate T cell activation. Recently, we have demonstrated that human soluble BAFF (hsBAFF) potently elevates NK cell activity of murine splenic cells in vivo. In this study, we further show that hsBAFF markedly enhanced NK cell activity of in vitro mouse splenic cells. Purified NK cell activities treated with hsBAFF in the presence of IL-2 or IFN-gamma, but not with hsBAFF alone were obviously elevated. hsBAFF strongly increased the activity of NK cells co-incubated with mixed T and B lymphocytes or T lymphocytes alone, but not with B lymphocytes alone. We also found that culture supernatants, from mixed T and B lymphocytes or T lymphocytes alone, but not from B lymphocytes alone post-hsBAFF treatment, effectively increased NK cell activity, and noticed that IL-2 and IFN-gamma levels significantly increased in the culture supernatants of hsBAFF-treated T lymphocytes. Of importance, we pinpointed that hsBAFF elicited robust population of CD4(+) T lymphocytes in vitro, and further demonstrated that hsBAFF induced significantly high IL-2 and IFN-gamma secretion of CD4(+) T lymphocytes. These findings indicate that hsBAFF results in the elevation of NK cell activity by regulation of CD4(+) T lymphocytes contributing to IL-2 and IFN-gamma generation.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Zhang W,Wen L,Huang X,Liang J,Gao W,Zhang S,Chen L

doi

10.1016/j.imlet.2008.07.005

subject

Has Abstract

pub_date

2008-10-30 00:00:00

pages

96-102

issue

1-2

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(08)00185-5

journal_volume

120

pub_type

杂志文章

相关文献

IMMUNOLOGY LETTERS文献大全
  • The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells.

    abstract：:Maturation of dendritic cells is a key step during induction of adaptive immune responses. Multiple pathways and factors are involved in the regulation of dendritic cell maturation. Alternative splicing of pre-mRNA, which is regulated by splicing factors, plays an important role in many biological processes, including...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.06.004

    authors： Jia R,Li X,Yu C,Fan M,Guo J

    更新日期：2013-06-01 00:00:00

  • Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways.

    abstract：:Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(02)00010-x

    authors： An H,Xu H,Yu Y,Zhang M,Qi R,Yan X,Liu S,Wang W,Guo Z,Qin Z,Cao X

    更新日期：2002-05-01 00:00:00

  • Cytokine effects on a B-cell line.

    abstract：:The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(84)90085-3

    authors： Stanton T,Maynard M

    更新日期：1984-01-01 00:00:00

  • Efficient generation of a monoclonal antibody against the human C-type lectin receptor DCIR by targeting murine dendritic cells.

    abstract：:Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral i...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2010.06.002

    authors： Heidkamp GF,Neubert K,Haertel E,Nimmerjahn F,Nussenzweig MC,Dudziak D

    更新日期：2010-08-16 00:00:00

  • Liver nonparenchymal cells involved in hyporesponsiveness induced by portal vein injection of alloantigen.

    abstract：INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(01)00322-4

    authors： Chen Y,McKenna GJ,Ong C,Mui AL,Chung SW

    更新日期：2002-04-01 00:00:00

  • Eosinophil-mediated cellular cytotoxicity induced by zymosan-activated serum.

    abstract：:The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90078-7

    authors： De Simone C,Ferrari M,Pugnaloni L,Ferrarelli G,Rumi C,Sorice F

    更新日期：1986-01-01 00:00:00

  • Inclusion bodies from recombinant bacteria as a novel system for delivery of vaccine antigen by the oral route.

    abstract：:A fragment of non-glycosylated E2 antigen of classical swine fever virus (CSFV), lacking the trans-membrane anchor (TM-) of the native glycoprotein, was produced in recombinant Escherichia coli strain BL21(DE3) in the form of inclusion bodies. These inclusion bodies isolated from the bacteria cells were administrated ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2003.12.001

    authors： Kesik M,Saczyńska V,Szewczyk B,Płucienniczak A

    更新日期：2004-02-15 00:00:00

  • CD45RA-expressing memory/effector Th cells committed to production of interferon-gamma lack expression of CD31.

    abstract：:It has been considered before that human naive and memory/effector CD4+ T-cells cannot be subdivided solely according to the differential expression of CD45 isoforms. By the lack of expression of CD31 we have identified a subset of CD4+ CD45RA+ CD31- cells which show distinct features of antigen-experienced Th1 cells....

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(97)00056-4

    authors： Thiel A,Schmitz J,Miltenyi S,Radbruch A

    更新日期：1997-06-01 00:00:00

  • Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E(2).

    abstract：:Donor-specific blood transfusion (DST) improves allograft survival, although the exact mechanism(s) is not completely understood. The purpose of this study was to determine the role of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in DST-protective effects, using a rat cardiac transplantation model. Lewis rats (RT...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(02)00086-x

    authors： Inuzuka S,Koga S,Nishikido M,Miyata Y,Kanda S,Shimokawa I,Tanaka M,Saito Y,Kanetake H

    更新日期：2002-09-02 00:00:00

  • Interaction between viruses and monoclonal antibodies studied by surface plasmon resonance.

    abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(92)90011-c

    authors： Dubs MC,Altschuh D,Van Regenmortel MH

    更新日期：1992-01-01 00:00:00

  • Apoptosis and the CD95 system in HIV disease: impact of highly active anti-retroviral therapy (HAART).

    abstract：:Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(98)00167-9

    authors： Gougeon ML,Lecoeur H,Sasaki Y

    更新日期：1999-03-01 00:00:00

  • Early induction of anti-double-stranded DNA antibodies in lupus-prone MRL mice inoculated with Ly-24+ cells cloned from lymph node cells of an MRL/Mp-lpr/lpr mouse: possible effect of putative cytokines produced by cloned Ly-24+ cells.

    abstract：:We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(90)90035-o

    authors： Kanai Y,Isonishi S,Katagiri T,Koizumi T,Miura K,Kurosawa Y

    更新日期：1990-03-01 00:00:00

  • Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T-cell clone.

    abstract：:A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(97)02696-5

    authors： Buseyne F,Stevanovic S,Rammensee HG,Rivière Y

    更新日期：1997-03-01 00:00:00

  • Induction and characterization of antisera against terminal and internal peptides of SV40 large T antigen.

    abstract：:Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as d...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90006-4

    authors： Friedrich U,Scheidtmann KH,Walter G

    更新日期：1986-04-01 00:00:00

  • Adjuvant effect of liposomes in the autoimmune response to rat male accessory glands.

    abstract：:Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(91)90125-t

    authors： Correa SG,Riera CM

    更新日期：1991-04-01 00:00:00

  • Use of antibody gene library for the isolation of specific single chain antibodies by ampicillin-antigen conjugates.

    abstract：:Isolation of recombinant antibodies from antibody libraries is commonly performed by different molecular display formats including phage display and ribosome display or different cell-surface display formats. We describe a new method which allows the selection of Escherichia coli cells producing the required single ch...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.02.005

    authors： Neumann-Schaal M,Messerschmidt K,Grenz N,Heilmann K

    更新日期：2013-03-01 00:00:00

  • Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood.

    abstract：:This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(85)90046-x

    authors： Pass A,Avidor B,Golenser J,Laskov R,Sulitzeanu D

    更新日期：1985-01-01 00:00:00

  • FcgammaRI (CD64) resides constitutively in lipid rafts.

    abstract：:Cellular membranes contain microdomains known as 'lipid rafts' or detergent-insoluble microdomains (DRM), enriched in cholesterol and sphingolipids. DRM can play an important role in many cellular processes, including signal transduction, cytoskeletal organization, and pathogen entry. Many receptors like T cell recept...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2007.12.003

    authors： Beekman JM,van der Linden JA,van de Winkel JG,Leusen JH

    更新日期：2008-03-15 00:00:00

  • Possible conformation of interferons: a prediction based on amino acid composition and sequence.

    abstract：:Using the method of estimation of alpha-helical and beta-folded types of secondary structure from amino acid composition, it has been established that interferons contain about 60-70% of alpha-helices and not more than 10-20% of beta-structure. The same result was obtained using empirical and stereochemical rules for ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(82)90070-0

    authors： Zav'yalov VP,Denesyuk AI

    更新日期：1982-01-01 00:00:00

  • Differential modulation of host macrophage function by AK-5 tumor is dependent on the site of tumor transplantation.

    abstract：:We have studied the mechanisms involved in the activation or suppression of the immune response by the tumor cells, which is also dependent on the site of tumor transplantation. AK-5 tumor cells when transplanted s.c. activated peritoneal macrophages through the induction of different cytokines, whereas tumor cells wh...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(02)00034-2

    authors： Mitra R,Bhaumik S,Khar A

    更新日期：2002-07-03 00:00:00

  • Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO.

    abstract：:The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2012.06.005

    authors： Inostroza-Nieves Y,Venkatraman P,Zavala-Ruiz Z

    更新日期：2012-09-01 00:00:00

  • Effects of interleukin-2 on bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching.

    abstract：:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2015.06.009

    authors： Aksyonov A,Mitrokhin VM,Mladenov MI

    更新日期：2015-09-01 00:00:00

  • Enhancement of complement-induced cell lysis: a novel mechanism for the anticancer effects of Hsp90 inhibitors.

    abstract：:Molecular chaperones (heat shock proteins, Hsp-s) play a pleiotropic role in immunological functions. Hsp-s participate in the presentation of peptide antigens, folding of several immunologically important proteins, such as the MHC, and in the maintenance of the activation-competent conformation of key signaling molec...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2003.11.025

    authors： Sreedhar AS,Nardai G,Csermely P

    更新日期：2004-03-29 00:00:00

  • The involvement of multifunctional TGF-β and related cytokines in pathogenesis of endometriosis.

    abstract：PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2018.10.011

    authors： Sikora J,Smycz-Kubańska M,Mielczarek-Palacz A,Bednarek I,Kondera-Anasz Z

    更新日期：2018-09-01 00:00:00

  • Induction of complement-mediated lysis of HIV-1 by a combination of HIV-specific and HLA allotype-specific antibodies.

    abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...

    journal_title：Immunology letters

    pub_type： 信件

    doi：10.1016/j.imlet.2009.08.005

    authors： Hildgartner A,Wilflingseder D,Gassner C,Dierich MP,Stoiber H,Bánki Z

    更新日期：2009-09-22 00:00:00

  • Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3.

    abstract：:Satratoxins have been recognized as potential immunomodulatory agents in outbreaks of building-related illness. Here we report that satratoxin G-treated human leukemia HL-60 cells underwent apoptosis through the action of caspase-3 which was activated by both caspase-8 and caspase-9. Western blot analysis of caspase-3...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(02)00127-x

    authors： Nagase M,Shiota T,Tsushima A,Murshedul Alam M,Fukuoka S,Yoshizawa T,Sakato N

    更新日期：2002-10-21 00:00:00

  • Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G.

    abstract：:A monoclonal human rheumatoid factor (RF-AN) reactive with human Fc gamma is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having C gamma 2 or C gamma 3 domain deletions or IgG3m (5) or Ig3m (21) proteins having argi...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(84)90042-7

    authors： Jefferis R,Nik Jaafar MI,Steinitz M

    更新日期：1984-01-01 00:00:00

  • Down-regulation of murine B lymphocyte growth: arrest of B cells in G1 underlies immunosuppression induced by an IgM antibody.

    abstract：:Previous studies have demonstrated that culture supernatants of LPS-stimulated murine splenic B lymphocytes (BLPSSN) are able to inhibit the growth of freshly isolated B cells via an IgM antibody. In this work we investigated the progress of LPS-activated B lymphocytes through the cell cycle in the presence of this an...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(92)90070-5

    authors： Uher F,Mihalik R,Alonso ME,Gergely J

    更新日期：1992-08-01 00:00:00

  • The ambiguity of opioids revealed by immunology is changing the knowledge and the therapeutic approach in cancer and non-cancer pain: A narrative review.

    abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2020.06.011

    authors： Santoni A,Arcuri E

    更新日期：2020-10-01 00:00:00

  • Variations of serum IgG subclass levels in hepatitis C virus infection during interferon-alpha therapy.

    abstract：:Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual va...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(96)02681-8

    authors： Musset L,Ghillani P,Lunel F,Cacoub P,Cresta P,Frangeul L,Rosenheim M,Preud'homme JL

    更新日期：1997-01-01 00:00:00