Abstract：
:Two of the better characterized antimicrobial mechanisms displayed by human neutrophils are the reactive oxygen species (ROS) production and the induction of apoptosis. Their importance in mycobacterial infections is, however, controversial and we aimed to analyze them simultaneously in neutrophils infected with either Mycobacterium tuberculosis or the non-pathogenic M. gordonae. Neither species is eliminated by neutrophils but the pattern exhibited for both activities is completely different. M. tuberculosis induces ROS production and apoptosis but M. gordonae does not. Additional evidence was provided by an attenuated strain of M. gordonae that, although it has become susceptible to the antimicrobial activity of neutrophils, it still does not promote ROS production or apoptosis. Therefore no relationship could be established between any of these activities and the ability of neutrophils to kill mycobacteria. We have also observed that neutrophil concentration, a variable that is important in the antimicrobial activity against other pathogens, has no influence in the mycobacterial intracellular growth.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
González-Cortés C,Reyes-Ruvalcaba D,Diez-Tascón C,Rivero-Lezcano OMdoi
10.1016/j.imlet.2009.07.006subject
Has Abstractpub_date
2009-09-22 00:00:00pages
16-21issue
1-2eissn
0165-2478issn
1879-0542pii
S0165-2478(09)00181-3journal_volume
126pub_type
杂志文章abstract：:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2009.08.004
更新日期：2009-09-22 00:00:00
abstract：:Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90125-t
更新日期：1991-04-01 00:00:00
abstract：:To examine whether grape seed proanthocyanidin extract (GSPE) which is known to act as an antioxidant has therapeutic effect on collagen-induced arthritis (CIA) in mice, an animal model of rheumatoid arthritis. Mice were treated with an intraperitoneal injection of GSPE (10, 50, or 100 mg/kg) or saline. Clinical, hist...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.05.001
更新日期：2009-06-04 00:00:00
abstract：:Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.06.002
更新日期：2010-08-16 00:00:00
abstract：:Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual va...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02681-8
更新日期：1997-01-01 00:00:00
abstract：:T-cell immunoglobulin mucin-1 (TIM-1) is associated with the regulation of T helper type 2 (Th2) immune responses and has been associated with asthma susceptibility. Previous studies have shown that administration of TIM-1 results in T cell hyperproliferation and increased Th2 cytokine secretion. TIM-1 has also been s...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.11.004
更新日期：2007-01-15 00:00:00
abstract：:The influence of pretreatment with interferon (IFN) on subsequent IFN synthesis was investigated in macrophage cultures of DBA/2 and C57BL/6 mice. The doses of IFN alpha/beta for pretreatment ranged from 10,000 U/ml to 100 U/ml and the incubation time was between 18 and 2 h. No blocking effect was observed for chemica...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90049-1
更新日期：1988-06-01 00:00:00
abstract：:E1, E3-deleted, replication-deficient recombinant adenoviruses are widely studied as vectors for their capacity to transfer therapeutic genes in vivo. They can infect a wide variety of dividing and quiescent cells from different organs and possess a large packaging capacity. One of the major limitations in the use of ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00049-7
更新日期：1997-06-01 00:00:00
abstract：:The induction of antigen (Ag)-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. Recently, attention has been focused on induction of active suppression by regulatory T cells (Treg cells). Also, a role for dendritic cells (DCs) in the promotion of peripheral tolera...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2004.04.015
更新日期：2004-06-15 00:00:00
abstract：:In this study, we tried to establish a relationship between the immunopotentiating effects and the antioxidant activity of the immunostimulating compound, diethyldithiocarbamate (DDC). We studied the effects of DDC treatment on enriched T and B murine spleen lymphocytes in an in vivo-ex vivo model of O2-induced immune...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90048-x
更新日期：1988-06-01 00:00:00
abstract：:We have examined whether the interaction of peptide-loaded MHC molecules on the surface of B-cells with antigen-specific T-cell receptors (TCRs) enhances Ig secretion in the presence of other antigen-independent interactions in vitro. B-cells specific for region 25-40 of beta-lactoglobulin (beta-LG) were stimulated in...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00002-9
更新日期：1998-04-01 00:00:00
abstract：:The Nramp1 gene was originally described as Ity/Lsh/Bcg, a single gene controlling resistance and susceptibility of inbred mice to a range of intramacrophage pathogens. Functional studies demonstrated that Ity/Lsh/Bcg had multiple pleiotropic effects on macrophage activation pathways, broadening interest in the gene t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00127-8
更新日期：1999-01-01 00:00:00
abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00163-4
更新日期：1994-12-01 00:00:00
abstract：:Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90155-6
更新日期：1987-12-01 00:00:00
abstract：:Development of active TB is accompanied by immune suppression and the underlining mechanisms have been explored extensively in recent years. MDSCs are a heterogeneous group of immature and progenitor myeloid cells with strong immunosuppressive ability for both natural and adaptive immunity. In our analysis of CD244 (2...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.12.003
更新日期：2014-03-01 00:00:00
abstract：:Wnt5a is a secreted pleiotropic glycoprotein produced in an inflammatory state by a wide spectrum of ubiquitous cell populations. Recently, we demonstrated that Wnt5a skews the differentiation of human monocyte derived dendritic cells (moDCs) to a tolerogenic functional state. In this study we focus our interest on th...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.08.015
更新日期：2014-11-01 00:00:00
abstract：:Molecular chaperones (heat shock proteins, Hsp-s) play a pleiotropic role in immunological functions. Hsp-s participate in the presentation of peptide antigens, folding of several immunologically important proteins, such as the MHC, and in the maintenance of the activation-competent conformation of key signaling molec...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2003.11.025
更新日期：2004-03-29 00:00:00
abstract：:There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2017.11.014
更新日期：2018-02-01 00:00:00
abstract：:Chronic rheumatoid arthritis (RA) is characterized by the hyperplasia of synovial tissue, which results from dysregulation of proliferative and antiapoptotic signals transduced in the synovial cells by unknown mechanisms. To identify candidate factors involved in the regulation of synovial hyperplasia, the expression ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.07.002
更新日期：2003-12-15 00:00:00
abstract：:Between the ages of 2 to approximately 11 days mice respond to a challenge with syngeneic IgE by producing anti-IgE antibodies; by the age of 2 weeks they are unresponsive. Even adult mice, however, produce high titers of anti-IgE antibodies when immunized with a conjugate of syngeneic IgE and a foreign antigen such a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00087-3
更新日期：1995-09-01 00:00:00
abstract：:We studied isotype profiles of anti-HIV antibodies (Ab) in HIV-1-infected African patients with high viral loads and major B cell dysfunction. We focussed on IgG1, IgG3, and IgA as these classes and subclasses tend to support neutralizing functions against HIV. Total IgG1, IgG3 and IgA were detected in the plasma of b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.02.004
更新日期：2004-04-30 00:00:00
abstract：:While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.11.005
更新日期：2005-04-15 00:00:00
abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.017
更新日期：2014-12-01 00:00:00
abstract：:CD103(+)CD11b(+) dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103(+)CD11b(+) DC...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.05.012
更新日期：2016-08-01 00:00:00
abstract：:Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90193-r
更新日期：1992-03-01 00:00:00
abstract：:Investigating the functional effects of anti-T cell monoclonal antibodies (obtained through the Second International Workshop on Human Leucocyte Differentiation Antigens), antibodies to the sheep red cell receptor (CD2) were found to block lectin-dependent cytotoxicity. Blocking was seen with all anti-CD2 reagents tes...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90151-8
更新日期：1985-01-01 00:00:00
abstract：:The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90183-x
更新日期：1994-05-01 00:00:00
abstract：:In a recent, thought-provoking novel by Elizabeth McCracken (The Giant's House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be "immune to love", explaining the concept to his perplexed interlocutor, "...people become immune to love like they become immune to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00181-3
更新日期：1999-03-01 00:00:00
abstract：:Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.014
更新日期：2014-12-01 00:00:00
abstract：:We established two clones of monoclonal hybridoma, from a non-immunized NZB mouse, which produce IgM class hemagglutinating autoantibodies reactive with the exposed murine erythrocyte autoantigens. Absorption studies revealed that one monoclonal antibody exhibits cross-reactivity to chick erythrocytes and mouse liver,...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90062-2
更新日期：1984-01-01 00:00:00
