Abstract:
:Investigating the functional effects of anti-T cell monoclonal antibodies (obtained through the Second International Workshop on Human Leucocyte Differentiation Antigens), antibodies to the sheep red cell receptor (CD2) were found to block lectin-dependent cytotoxicity. Blocking was seen with all anti-CD2 reagents tested regardless of epitope specificity, immunoglobulin subclass or other factors. Antibodies to other T cell differentiation antigens had no effect.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Görög G,Laskay T,Petrányi GGdoi
10.1016/0165-2478(85)90151-8subject
Has Abstractpub_date
1985-01-01 00:00:00pages
107-9issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(85)90151-8journal_volume
11pub_type
杂志文章abstract::When human peripheral blood lymphocytes (PBL) are cultured with either concanavalin A (Con A)-treated or control autologous T lymphocytes, the mitogenic responses of the PBL co-cultured with Con A-treated cells are much lower. We have investigated the cell surface receptor changes during culture of T cells with and wi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90031-2
更新日期:1984-01-01 00:00:00
abstract::The effect of melphalan (L-PAM; L-phenylalanine mustard) administration on natural killer (NK) and natural cytotoxic (NC) activities of spleen cells from normal noninoculated BALB/c mice and mice bearing large MOPC-315 plasmacytoma tumors was investigated. Injection of L-PAM (7.5 or 15.0 mg/kg) had no effect on NK and...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90128-2
更新日期:1985-01-01 00:00:00
abstract::Both CD8 and CD2 are T cell surface receptors involved in physical cell interaction and in transmembrane signalling. The present paper addresses their role in the induction of two different functions of the cloned murine cytotoxic T cell C196: target cell lysis and IFN-gamma production. These functions were induced in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90018-6
更新日期:1991-10-01 00:00:00
abstract::The immunosuppressant rapamycin is known to be a potent inhibitor of cytokine driven proliferation of T-lymphocytes and other cell types. Here we have examined the effect of rapamycin on the myeloblastic cell line M1 which responds to interleukin-6 (IL-6) with growth arrest and monocytoid differentiation. Single-agent...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00110-7
更新日期:1997-11-01 00:00:00
abstract::Soluble C3d applied to human blood-derived B lymphocytes inhibited anti-mu, T cell-produced growth factor, and EBV-induced DNA synthesis in serum-free culture. C3d added to the B cell cultures 1 and 2 days after the stimulus, still exerted inhibition, though with gradually diminishing efficiency. C3d, fixed on zymosan...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90175-p
更新日期:1990-10-01 00:00:00
abstract:PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.10.011
更新日期:2018-09-01 00:00:00
abstract::Natural anti-cholesterol antibodies (ACHAs) exist in mammalian species, moreover their level sensitively changes in pathological situations, such as atherosclerosis or HIV infection. The conditions of their production and functional role, however, still remained ill defined. Recently we developed IgG3 type monoclonal ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.01.009
更新日期:2012-03-30 00:00:00
abstract::Homogeneous IgG fractions were obtained by chromatography of the sera of patients with multiple sclerosis (MS) on Protein G-Sepharose under conditions that remove non-specifically bound proteins. These IgGs contained several chelated metals, the relative amount of which decreases in the order: Fe>or=Ca>Cu>or=Zn>or=Mg>...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.10.018
更新日期:2006-02-28 00:00:00
abstract::During a pathogenic infection, an inflammatory process is triggered in which several inflammatory mediators, such as cytokines, chemokines, growth factors, complement system components, nitric oxide, and others induce integrity alteration on the endothelial barrier. Chemokines are responsible for regulating leukocyte ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2019.06.001
更新日期:2019-08-01 00:00:00
abstract::The immunomodulating properties of a neuropeptide hormone, corticotropin-releasing factor (CRF), led us to investigate its effect on cAMP production by human peripheral blood mononuclear cells (MNC). In response to stimulation with CRF (100 nM), a statistically significant (P = 0.019) increase occurred in the amount o...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90189-9
更新日期:1993-03-01 00:00:00
abstract::Recombinant gp120 of the HIV-1(IIIB) isolate (BH10 clone) has been mutated to form the PR12 protein with the first 74 C-terminal amino acids and the V1, V2 and V3 hypervariable loops deleted. A variety of studies have shown that the CD4 binding domain (CD4bd) is very well exposed in PR12 in contrast to rgp120(LAI). Us...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00289-9
更新日期:2001-12-03 00:00:00
abstract::The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.015
更新日期:2014-12-01 00:00:00
abstract::To monitor genetically-controlled cytokine-producing ability in mice in vitro, we developed a high-density cell culture system, which is preferable for inducing CD4+ T cell-dependent self-priming responses without any antigenic stimulation. When BALB/c spleen cells were cultured at high density (over 1.0 x 10(7) cells...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00143-1
更新日期:1999-12-01 00:00:00
abstract::The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)00163-4
更新日期:1994-12-01 00:00:00
abstract::The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00126-0
更新日期:1998-01-01 00:00:00
abstract::Both, HIV envelope proteins gp120 and gp41 can directly activate complement system, even in the absence of HIV-specific antibodies. During the budding process HIV acquires host membrane-associated molecules among these complement regulatory proteins (CRPs). The presence of CRPs on the viral surface rescues HIV from co...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2004.11.007
更新日期:2005-03-15 00:00:00
abstract::Recently, a newly identified human HERV-K18 like endogenous retrovirus (IDDMK(1,2)22) has been associated to the etiology of type I diabetes (IDDM). Although the exact mechanism remains unclear, it was postulated that the 3' end ORF product of the env gene of IDDMK(1,2)22 would trigger a V beta 7-specific human T cell...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00340-6
更新日期:2002-04-01 00:00:00
abstract::A rapid, sensitive and simple method is provided for detecting Bence-Jones proteins in unconcentrated urine by electrosyneresis. This is based on the fact that the free light-chains, similar to the intact immunoglobulin molecules, form complexes with albumin under the effect of glutaraldehyde. Consequently, the origin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90005-6
更新日期:1983-04-01 00:00:00
abstract::Natural levels of goat antiphosphorylethanolamine (anti-PE) antibodies decreased after injection of purified human C-reactive protein (CRP). The concentration of anti-CRP antibodies followed a continuous increment from non-detectable levels to a plateau at 80 days after first injection. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90070-3
更新日期:1988-05-01 00:00:00
abstract::Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.02.008
更新日期:2017-04-01 00:00:00
abstract::We investigated IgE-mediated allergic responses in a metabolic syndrome model rat strain, SHRSP.Z, which develops obesity and hypertension to cast light on the relationship between metabolic disturbances and allergic responses. IgE-mediated cutaneous anaphylactic responses were severely attenuated in this strain regar...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.11.007
更新日期:2010-01-18 00:00:00
abstract::The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.03.001
更新日期:2009-04-27 00:00:00
abstract::Wnt5a is a secreted pleiotropic glycoprotein produced in an inflammatory state by a wide spectrum of ubiquitous cell populations. Recently, we demonstrated that Wnt5a skews the differentiation of human monocyte derived dendritic cells (moDCs) to a tolerogenic functional state. In this study we focus our interest on th...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.08.015
更新日期:2014-11-01 00:00:00
abstract::The binding of anti-IgM IgG to human monoclonal IgM has been studied calorimetrically and results have been compared with parallel turbidity measurements of the same reaction. In the first series of experiments using the flow calorimeter equipped with a mixing cell, varied flow rates gave identical values for the ther...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90091-9
更新日期:1984-01-01 00:00:00
abstract::Blood coagulation and inflammation pathways are linked in many aspects. A number of serum factors involved in coagulation cascades affect directly or indirectly inflammatory responses, whereas proinflammatory cytokines influence blood coagulation pathways. In this work we demonstrated that thrombin is an effective sti...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00015-2
更新日期:1999-04-15 00:00:00
abstract::The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...
journal_title:Immunology letters
pub_type: 信件
doi:10.1016/j.imlet.2008.06.002
更新日期:2008-08-15 00:00:00
abstract::Leukaemic blood lymphocytes from patients with B prolymphocytic leukaemia express the common acute lymphoblastic leukaemia antigen (CALLA). The in vitro incubation of prolymphocytes with leucocyte conditioned medium produced the acquisition of plasma cell morphology, of intracytoplasmic immunoglobulins and the simulta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90005-7
更新日期:1985-01-01 00:00:00
abstract::It was attempted to monitor the immunological response of monoclonal antibodies directed to human alkaline phosphatase in ancient Egyptian bones from the ptolemeic period. The intactness of the respective epitopes of the bone enzyme was successfully demonstrated in an ELISA. Fortunately, the mummified bone was not con...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)02467-0
更新日期:1995-12-01 00:00:00
abstract::CD103(+)CD11b(+) dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103(+)CD11b(+) DC...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.05.012
更新日期:2016-08-01 00:00:00
abstract::DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00235-8
更新日期:2001-09-03 00:00:00