Abstract:
:Leukaemic blood lymphocytes from patients with B prolymphocytic leukaemia express the common acute lymphoblastic leukaemia antigen (CALLA). The in vitro incubation of prolymphocytes with leucocyte conditioned medium produced the acquisition of plasma cell morphology, of intracytoplasmic immunoglobulins and the simultaneous reduction of CALLA expression. The presence of CALLA appears to be unrelated to different clinical courses. Our report demonstrates that the antigen is present also in relatively mature stages of B lymphocyte differentiation. The blastic appearance of prolymphocytes could suggest that CALLA may be related to active metabolism or function of these cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
de Paoli P,Battistin S,Fantin O,Nimis R,Reitano M,Santini Gdoi
10.1016/0165-2478(85)90005-7subject
Has Abstractpub_date
1985-01-01 00:00:00pages
263-6issue
5eissn
0165-2478issn
1879-0542pii
0165-2478(85)90005-7journal_volume
9pub_type
杂志文章abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifaceted hematopoietic cytokine and the culture of mouse bone marrow with GM-CSF produces a variety of myeloid cells including granulocytes, macrophages, and dendritic cells. In the present study, we cultured mouse splenocytes with GM-CSF and examined ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.03.003
更新日期:2016-05-01 00:00:00
abstract::Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.01.006
更新日期:2020-04-01 00:00:00
abstract::Domain deleted paraproteins are suitable tools to study the interaction between IgG domains and Fc receptor (FcR) binding sites. The effect of the C gamma 2 or C gamma 3 domain deleted paraproteins was compared on antibody dependent cellular cytotoxicity (ADCC) and on FcR mediated rosette formation. The C gamma 2 doma...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90035-0
更新日期:1986-06-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.02.004
更新日期:2004-04-30 00:00:00
abstract::Control animals and rats infected 90 days earlier, by inoculation of 1 x 10(6) trypomastigotes of Trypanosoma cruzi at weaning, were subjected to adult thymectomy (ATx) or sham operation (S-ATx) and assessed 3 months later for the presence of myocardial lesions and levels of lymph node and spleen T-cell populations. C...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90028-z
更新日期:1993-08-01 00:00:00
abstract::Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis facto...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.11.001
更新日期:2018-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.09.010
更新日期:2006-03-15 00:00:00
abstract::An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90011-c
更新日期:1992-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(99)00024-3
更新日期:1999-05-03 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02645-4
更新日期:1996-12-01 00:00:00
abstract::Inflammation elicits an acute phase response, which includes changes in plasma concentrations of a number of cytokines, reflecting changes in their gene transcription in the liver. In this study, the induction of complement factor 3 (C3) was investigated in HepG2 cells, a human hepatoma cell line often used as a model...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00180-8
更新日期:2001-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90050-x
更新日期:1992-05-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90120-3
更新日期:1986-08-01 00:00:00
abstract::Dendritic cells (DCs) are professional antigen presenting cells, well equipped to initiate an immune response. For effective induction of an immune response, DC should migrate from the periphery to the lymph node to present the antigen to T lymphocytes. Currently, tumor-antigen loaded DCs are used in clinical vaccinat...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00105-6
更新日期:2003-10-09 00:00:00
abstract::Clinical immunology is in the Netherlands a separate clinical specialty within internal medicine and pediatrics. Clinical immunologists work closely together with nephrologists, rheumatologists and many other medical specialists. Apart from research and teaching, clinical immunologists are taking care of patients with...
journal_title:Immunology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.imlet.2014.10.008
更新日期:2014-12-01 00:00:00
abstract::It was attempted to monitor the immunological response of monoclonal antibodies directed to human alkaline phosphatase in ancient Egyptian bones from the ptolemeic period. The intactness of the respective epitopes of the bone enzyme was successfully demonstrated in an ELISA. Fortunately, the mummified bone was not con...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)02467-0
更新日期:1995-12-01 00:00:00
abstract::Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90010-y
更新日期:1993-11-01 00:00:00
abstract::The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90135-x
更新日期:1994-07-01 00:00:00
abstract::To test whether apoptotic thymocytes can be identified by altered packing of lipids in their plasma membranes, thymocytes were isolated from mice injected with hydrocortisone and stained with merocyanine 540 (MC540), a fluorescent probe sensitive to lipid packing. At 9-10 h after injection, a subpopulation of H2-Klo c...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90101-7
更新日期:1993-06-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90122-8
更新日期:1994-07-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90158-7
更新日期:1991-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.08.007
更新日期:2013-07-01 00:00:00
abstract::Mechanistic target for rapamycin (mTOR) is a serine/threonine protein kinase that forms two distinct complexes mTORC1 and mTORC2, integrating mitogen and nutrient signals to regulate cell survival and proliferation; processes which are commonly deregulated in human cancers. mTORC1 and mTORC2 have divergent molecular a...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2018.01.015
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.05.005
更新日期:2013-05-01 00:00:00
abstract::When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90160-x
更新日期:1987-12-01 00:00:00
abstract::The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00029-4
更新日期:2003-05-01 00:00:00
abstract::A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02550-3
更新日期:1996-06-01 00:00:00
abstract::The present study was designed to investigate whether human equivalents of murine T helper cell subsets can be demonstrated by propagation of peripheral blood lymphocytes (PBL) with either recombinant human (rh) interleukin (IL) 2 or rhIL4 in the presence of neutralising antibodies. Cells of both cultures, termed T-IL...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90142-w
更新日期:1991-02-01 00:00:00
abstract::Mice lacking suppressor of cytokine signaling 1 (SOCS1) accumulate CD8(+) T lymphocytes in the thymus and in the periphery. Whereas IL-7 and IL-15 promote the generation of CD8 single positive (SP) thymocytes, IL-15 drives the expansion of CD8 T cells in the periphery. Here, we investigated whether increased productio...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.04.009
更新日期:2010-08-16 00:00:00
abstract::Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line. In Jurkat lymphoma cells, AFP decreases the synthesis of prostaglandins and increases the release of arachidonic acid and leukotrienes. The...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90092-7
更新日期:1987-01-01 00:00:00