Abstract:
:In a recent, thought-provoking novel by Elizabeth McCracken (The Giant's House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be "immune to love", explaining the concept to his perplexed interlocutor, "...people become immune to love like they become immune to any disease. Either they had it bad early in life, like chicken pox and that's that; or they keep getting exposed to it in little doses and build up an immunity; or somehow they just don't catch it, something in'em is born resistant. I'm the last type. I'm immune to love and poison ivy". (p. 275) (E. McCracken, The Giant's House. Avon Books, New York, 1997). Substitute the words 'HIV infection' for 'love' and this intriguing metaphor summarizes the state of the art working hypotheses for the phenomenon of resistance to HIV infection in HIV-exposed individuals who, against all odds, do not seroconvert. These hypotheses will be discussed hereafter and particular emphasis will be placed upon a possible role for mucosal immunity in this phenomenon.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Clerici M,Salvi A,Trabattoni D,Lo Caputo S,Semplici F,Biasin M,Ble C,Meacci F,Romeo C,Piconi S,Mazzotta F,Villa ML,Mazzoli Sdoi
10.1016/s0165-2478(98)00181-3subject
Has Abstractpub_date
1999-03-01 00:00:00pages
21-5issue
1-3eissn
0165-2478issn
1879-0542pii
S0165-2478(98)00181-3journal_volume
66pub_type
杂志文章abstract::Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.06.002
更新日期:2010-08-16 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
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doi:10.1016/j.imlet.2008.11.001
更新日期:2009-01-29 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00275-3
更新日期:2000-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00183-8
更新日期:2000-05-01 00:00:00
abstract::In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(81)90095-x
更新日期:1981-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90056-3
更新日期:1987-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.08.025
更新日期:2017-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90070-5
更新日期:1992-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90155-1
更新日期:1988-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00330-3
更新日期:2002-03-01 00:00:00
abstract::Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...
journal_title:Immunology letters
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00104-9
更新日期:2002-10-01 00:00:00
abstract::Sepsis is an abnormal immune response to infection characterized by an overwhelming systemic inflammation and cell death. Non-apoptotic cell death pertaining to pyroptosis, necroptosis and autophagy contribute to sepsis pathogenesis apart from classical apoptotic cell death. The objective of the current study is to in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.12.009
更新日期:2021-01-03 00:00:00
abstract::CD8+CD28- regulatory T cells (Tregs) play important roles in chronic viral infections. Programmed death 1 (PD-1) is highly expressed on hepatitis C virus (HCV)-specific CTLs. However, little is known regarding the role of CD8+CD28-PD1+ T cells in hepatitis C. Herein, we found that the frequency of CD8+CD28-PD1+, but n...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.07.008
更新日期:2018-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90046-4
更新日期:1984-01-01 00:00:00
abstract::Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.05.002
更新日期:2013-05-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by the destruction of insulin-secreting β cells upon autoreactive T cell attack. Oral administration of autoantigens is an attractive approach to treating T1DM, but an effective carrier should be used in order to protect antigens. Lactococcu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.04.008
更新日期:2016-06-01 00:00:00
abstract::Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90013-7
更新日期:1987-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.10.006
更新日期:2020-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.12.002
更新日期:2007-02-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90063-9
更新日期:1983-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(00)00251-0
更新日期:2000-09-15 00:00:00
abstract::The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.05.010
更新日期:2009-06-30 00:00:00
abstract::Monoclonal antibodies of the Orthoclone series were used to identify total T lymphocytes (OKT3) and their helper-inducer (OKT4) and cytotoxic-suppressor (OKT8) subsets in 25 patients with chronic Chagas' disease and 25 healthy controls. No significant difference in the number of total T cells (OKT3+) circulating in th...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90011-7
更新日期:1984-01-01 00:00:00
abstract::This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90046-x
更新日期:1985-01-01 00:00:00
abstract::The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90004-5
更新日期:1985-01-01 00:00:00
abstract::This article has been withdrawn at the request of the authors and Guest Editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.09.015
更新日期:2009-10-04 00:00:00
abstract::Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.10.020
更新日期:2006-03-15 00:00:00
abstract::The prevalence of asthma and allergic disease has increased in many countries and there has been speculation that immunization promotes allergic sensitization. Bordetella pertussis infection exacerbates allergic asthmatic responses. We investigated whether whole-cell pertussis vaccine (Pw) enhanced or prevented B. per...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.10.011
更新日期:2005-02-15 00:00:00