Abstract:
:Melanoma is a prototype of immunogenic tumor to which various types of immunotherapy have been applied extensively over the past decades. Melanoma vaccines are designed for the purpose of immune modulation and subsequent anti-tumor effects in the process of an active specific immunotherapy. Previous attempts of these vaccines include immunization with whole tumor cells/cell lysates admixed with nonspecific adjuvants. While these vaccines generated enhanced anti-tumor immunity in a subset of patients, some of which showing prolonged survival compared to historical controls, no clinical benefit has so far been demonstrated in a properly controlled phase III study. New-generation melanoma vaccines, which are based on genetic modifications of tumor cells to express cytokines, generated long-lasting systemic anti-tumor immunity in animal models. Translation of these preclinical results primarily into melanoma patients with advanced diseases, shows the potential of these vaccines to induce systemic anti-tumor immune responses and in some instances tumor regression with acceptably low toxicity. Higher efficacy of this novel vaccine approach would be expected when used in a postsurgical adjuvant setting when the tumor load is small. Also other novel vaccine approaches such as dendritic cell-based therapy hold promise for the treatment of melanoma. But the clinical value of all these new approaches has to be analysed in prospectively randomized clinical studies.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Schadendorf D,Paschen A,Sun Ydoi
10.1016/s0165-2478(00)00251-0subject
Has Abstractpub_date
2000-09-15 00:00:00pages
67-74issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(00)00251-0journal_volume
74pub_type
杂志文章,评审abstract::The present study was designed to investigate whether human equivalents of murine T helper cell subsets can be demonstrated by propagation of peripheral blood lymphocytes (PBL) with either recombinant human (rh) interleukin (IL) 2 or rhIL4 in the presence of neutralising antibodies. Cells of both cultures, termed T-IL...
journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
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abstract::Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized...
journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
abstract::To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted durin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90201-1
更新日期:1994-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2007-02-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2009.12.009
更新日期:2010-05-04 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00015-2
更新日期:1999-04-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1982-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2016.02.014
更新日期:2016-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90150-9
更新日期:1991-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90103-9
更新日期:1987-02-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90104-a
更新日期:1993-06-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90040-8
更新日期:1983-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.05.013
更新日期:2005-11-15 00:00:00
abstract::Numerous studies have dealt with occurrence of dendritic cells in various nonlymphoid organs such as kidney, liver or heart, whereas lymphocyte patterns in these organs have not been analyzed in detail. In the present study, leukocytes were quantified as cells/mm2 in the perivascular, interstitial and parenchymal tiss...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02595-3
更新日期:1996-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.05.006
更新日期:2009-06-30 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.10.009
更新日期:2012-12-17 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.10.011
更新日期:2018-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2003-01-02 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
abstract::The production of neutralizing antibodies against the central portion of HIV-1 gp120 requires cooperation between T cell and B cell epitopes of this region. We found a motif common to the carboxyterminus of the second conserved region of HIV-1 gp120 and sequences of some human proteins, most of which participate in im...
journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1990-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00140-5
更新日期:1998-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:1999-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.imlet.2014.10.008
更新日期:2014-12-01 00:00:00
abstract::Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...
journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00