Abstract:
:Even though IgA is considered to play an important role in immunity, surprisingly little is known about the presence of IgA Fc receptor (Fc alpha R)-expressing effector cells in tissues. Difficulties in obtaining human tissue macrophages, led us to study peritoneal macrophages in a human Fc alpha RI transgenic (Tg) mouse model. Naive peritoneal macrophages did not express hFc alpha RI. Expression, however, could be induced by overnight culture, and was upregulated by GM-CSF. In addition, the receptor proved functional since macrophage-mediated phagocytosis and tumor cell kill were effectively triggered via hFc alpha RI. To assess necessity of the FcR gamma-chain signaling molecule for hFc alpha RI function in macrophages, Tg mice were crossed with mice deficient in FcR gamma-chain (gamma-/-). Tg, gamma-/- macrophages were unable to kill tumor cells. This, because Tg macrophages failed to express hFc alpha RI in the absence of FcR gamma-chain, and overnight culture did not overcome this lack of expression. Further studies with the transgenic mouse model presented in this study will help to define the precise conditions under which Fc alpha RI is expressed on macrophages. It will, furthermore, represent a useful tool to study Fc alpha RI function in immune defense.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
van Egmond M,Hanneke van Vuuren AJ,van de Winkel JGdoi
10.1016/s0165-2478(99)00034-6subject
Has Abstractpub_date
1999-05-03 00:00:00pages
83-7issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(99)00034-6journal_volume
68pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.imlet.2006.01.005
更新日期:2006-05-15 00:00:00
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.11.009
更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1982-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1983-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2017.11.014
更新日期:2018-02-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.11.009
更新日期:2017-01-01 00:00:00
abstract::Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...
journal_title:Immunology letters
pub_type: 信件
doi:10.1016/j.imlet.2009.08.004
更新日期:2009-09-22 00:00:00