Abstract:
:Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, differentiation, and cytoskeletal rearrangement of AECs, but it is not clear whether YAP regulates phagocytosis. In this study, interference with YAP expression inhibited phagocytosis in MLE-12 cells and in primary cultures of AEC. Filopodia formation promoted phagocytosis in AECs, and YAP enhanced filopodia formation in AECs. Blocking PI3K signaling resulted in reduced YAP protein expression and inhibition of phagocytosis. The results indicate that YAP expression was regulated by PI3K signaling and promoted phagocytosis in AECs by upregulating filopodia formation.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Gao P,Mu M,Chen Y,He J,Tao X,Song Cdoi
10.1016/j.imlet.2020.06.009subject
Has Abstractpub_date
2020-09-01 00:00:00pages
44-49eissn
0165-2478issn
1879-0542pii
S0165-2478(20)30334-5journal_volume
225pub_type
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