Abstract:
:The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation product, thromboxane B2 (TXB2), was studied. Tuftsin causes both albumin-elicited and C. parvum-activated møo to set free superoxide anion (O2) and hydrogen peroxide (H2O2). It also stimulates the liberation of TXB2 from albumin-elicited møo. The demonstrated induction of the release of toxic oxygen species from møo by tuftsin may explain how tuftsin-augmented møo-mediated cytotoxicity is accomplished.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Hartung HP,Toyka KVdoi
10.1016/0165-2478(83)90021-4subject
Has Abstractpub_date
1983-01-01 00:00:00pages
1-6issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(83)90021-4journal_volume
6pub_type
杂志文章abstract::Rabbit anti-ovalbumin antibodies were found to bind to Swiss NIH 3T3 fibroblasts by indirect immunofluorescence, and to induce DNA synthesis when these cells were arrested in G0 phase of their replicating cycle (G0-S activity). The proof that these effects were related to the ovalbumin paratopes is based on the follow...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90069-1
更新日期:1987-05-01 00:00:00
abstract::We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90035-o
更新日期:1990-03-01 00:00:00
abstract::The cytotoxicity of natural killer (NK) and lymphokine activated killer (LAK) cells against two human bladder tumor cell lines (BT-A and BT-B) was investigated using a fluorometric assay by labeling tumor cell DNA with Hoechst dye No. 33342. Our results demonstrate that BT-A and BT-B cells have low sensitivity to the ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90150-9
更新日期:1991-03-01 00:00:00
abstract::It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02497-2
更新日期:1996-03-01 00:00:00
abstract::Treatment of purified human C5 with hydrogen peroxide leads to a reduction of functional activity in the classical immune haemolysis assay. The effect of H2O2 is enhanced by traces of iron-EDTA, and becomes even stronger when ascorbic acid is present in addition. The enhancement by iron and protective effects of vario...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90103-9
更新日期:1987-02-01 00:00:00
abstract::CD27, which belongs to the TNF receptor family, is a costimulatory molecule that participates in T-cell activation. Unlike costimulatory molecules such as OX40 and 4-1BB, little is known about the role CD27 plays a role in the development of experimental diseases. We asked whether CD27 and its ligand CD70 participate ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.05.004
更新日期:2008-08-15 00:00:00
abstract::Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.05.001
更新日期:2003-10-31 00:00:00
abstract:BACKGROUND AND PURPOSE:Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, has effects of dispelling wind and dampness, promoting blood circulation, and relieving pain. Our group has already studied and confirmed that POEa and POEe (ethyl acetate and ethyl ether extract of P. orientale, respectively)...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.11.009
更新日期:2018-09-01 00:00:00
abstract::The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90135-x
更新日期:1994-07-01 00:00:00
abstract::Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00177-2
更新日期:2000-05-01 00:00:00
abstract::T cells utilize the vascular adhesion molecule E-selectin to enter inflamed skin. T cells identified by the mAb HECA-452 [cutaneous lymphocyte-associated antigen (CLA) T cells] are enriched in E-selectin ligand expressing cells. However, the proportion of CLA(+) T cells reactive with an E-selectin/Fc chimeric construc...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.12.002
更新日期:2007-02-15 00:00:00
abstract::Cellular membranes contain microdomains known as 'lipid rafts' or detergent-insoluble microdomains (DRM), enriched in cholesterol and sphingolipids. DRM can play an important role in many cellular processes, including signal transduction, cytoskeletal organization, and pathogen entry. Many receptors like T cell recept...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2007.12.003
更新日期:2008-03-15 00:00:00
abstract::CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2011.10.008
更新日期:2012-01-30 00:00:00
abstract::Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.12.001
更新日期:2015-03-01 00:00:00
abstract::Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycy...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90040-x
更新日期:1987-06-01 00:00:00
abstract::The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly r...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.05.013
更新日期:2005-11-15 00:00:00
abstract::MHC tetramers are used to directly enumerate and visualize the antigen-specific T lymphocyte population of interest by flow cytometry, regardless of the T lymphocyte's functional capacity. Assay sensitivity can be hindered by non-specific binding activity, which is due to the inherent interactions of CD8 and MHC. Poin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.11.016
更新日期:2005-05-15 00:00:00
abstract:OBJECTIVES:Cytokine production from activated T cells play a pathogenetic role in mucosal lesions of coeliac disease (CD). Active interleukin (IL)-18 is expressed in the small intestinal mucosa in CD but not in healthy controls. IL-18 enhances intercellular adhesion molecule-1 (ICAM-1) expression. We analyzed IL-18 ser...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00243-2
更新日期:2003-02-03 00:00:00
abstract::Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.05.013
更新日期:2014-09-01 00:00:00
abstract::Differentiation between a non-infective and an infective Leishmania promastigote population was demonstrated. Promastigotes in the stationary phase (day 5) were found to be highly infective in vitro to BALB/c mouse peritoneal macrophages, compared with those of the logarithmic phase (day 3). The infective promastigote...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90114-2
更新日期:1985-01-01 00:00:00
abstract::As the most common non-traumatic disabling disease among adolescents, multiple sclerosis (MS) is a devastating neurological inflammatory disease of the central nervous system. Research has not yet fully elucidated its pathogenesis, but it has shown MS to be a complex, multifactorial disease with many interplaying fact...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.02.012
更新日期:2020-06-01 00:00:00
abstract::In this study, we tried to establish a relationship between the immunopotentiating effects and the antioxidant activity of the immunostimulating compound, diethyldithiocarbamate (DDC). We studied the effects of DDC treatment on enriched T and B murine spleen lymphocytes in an in vivo-ex vivo model of O2-induced immune...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90048-x
更新日期:1988-06-01 00:00:00
abstract::Angiogenic and poorly angiogenic tumor variants were obtained by an intraperitoneal inoculation of cells from clones of polyoma-virus transformed BALB/c 3T3 cells into syngeneic mice. The angiogenic tumor cells expressed a higher tumorigenicity phenotype and a higher capacity to produce artificial pulmonary metastases...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02675-2
更新日期:1996-12-01 00:00:00
abstract::Protective immunity against Salmonella infection is known to require CD4 Th1 cells and B cells, but the role of MHC class-I-restricted CD8 T cells is less clear. Previous studies have suggested that CD8 T cells participate in secondary, but not primary, bacterial clearance. However, these studies have used experimenta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.10.009
更新日期:2012-12-17 00:00:00
abstract:UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.03.018
更新日期:2004-05-15 00:00:00
abstract::Dendritic cells (DCs) differentiated in the presence of IL-10 preferentially induce regulatory T-cells and tolerance. Whether the tolerogenic properties displayed by these DCs (Tol-DCs) can be overcome has not been fully explored. Here we show for the first time that Tol-DCs express higher levels of TLR5 mRNA, but not...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.06.007
更新日期:2009-08-15 00:00:00
abstract::We report here that Trichosanthin (Tk), a primary active component isolated from a Chinese traditional medicinal herb, Trichosanthes kirilowii, potently inhibits lymphocyte proliferative response in vitro. We found that Tk treatment increased production of the interleukins IL-4 and IL-10, while production of IL-2 and ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2007.03.008
更新日期:2007-05-15 00:00:00
abstract::Recent advances in next-generation sequencing have enabled rapid and efficient evaluation of the mutational landscape of cancers. As a result, many cancer-specific neoantigens, which can generate antitumor cytotoxic T-cells inside tumors, have been identified. Previously, we reported a metastatic melanoma case with hi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.02.004
更新日期:2019-04-01 00:00:00
abstract::In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.04.005
更新日期:2020-07-01 00:00:00
abstract::When IL-4 mRNA was distinguished from mRNA encoding its antagonist, the splice variant IL-4delta2, it was found to correlate directly with expression of TLR2 in fresh peripheral blood mononuclear cells (PBMCs) from normal donors (p=0.0013). Similarly IL-4 mRNA was high when TLR2 mRNA was abundant compared to levels of...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.06.001
更新日期:2006-08-15 00:00:00