Abstract：
:As the most common non-traumatic disabling disease among adolescents, multiple sclerosis (MS) is a devastating neurological inflammatory disease of the central nervous system. Research has not yet fully elucidated its pathogenesis, but it has shown MS to be a complex, multifactorial disease with many interplaying factors. One of these factors, natural killer (NK) cells, lymphocytes of the innate immune system, have recently gained attention due to the effects of daclizumab therapy, causing an expansion of the immunoregulatory subset of NK cells. Since then, NK cells and their relation to MS have been the focus of research, with many new findings being published in the last decade. In this review, NK cells are pictured as potent cytotoxic killers, as well as unique immune-regulators. Additionally, an overview of our current knowledge regarding NK cells in MS is given. The role of NK cells in MS is reviewed in the context of well-established environmental factors and current disease modifying therapies to gain further understanding of the pathogenesis and treatment options in MS.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Mimpen M,Smolders J,Hupperts R,Damoiseaux Jdoi
10.1016/j.imlet.2020.02.012subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1-11eissn
0165-2478issn
1879-0542pii
S0165-2478(19)30645-5journal_volume
222pub_type
杂志文章,评审abstract：:Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.12.003
更新日期：2005-05-15 00:00:00
abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00163-4
更新日期：1994-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90035-0
更新日期：1986-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90073-6
更新日期：1994-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00227-i
更新日期：1995-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90127-6
更新日期：1986-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90114-2
更新日期：1985-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.11.018
更新日期：2006-04-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90063-9
更新日期：1983-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00061-3
更新日期：1998-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90092-3
更新日期：1992-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(99)00044-9
更新日期：1999-05-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.03.018
更新日期：2004-05-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.03.010
更新日期：2019-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02655-7
更新日期：1996-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.014
更新日期：2016-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.01.004
更新日期：2018-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2012-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.02.004
更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-2478(86)90053-2
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1989-01-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90109-n
更新日期：1991-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2021.01.001
更新日期：2021-01-06 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.06.006
更新日期：2009-06-30 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90069-1
更新日期：1987-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.03.005
更新日期：2017-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00340-6
更新日期：2002-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.12.002
更新日期：2018-02-01 00:00:00
abstract：:Different splice variants of the CD44 cell-surface molecule have been linked to metastasis formation in several animal and human cancers. We have used metastatic CSML-100 and non-metastatic CSML-0 mouse adenocarcinoma cell lines to determine whether variant CD44 molecules could be implicated in the different behaviour...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02588-6
更新日期：1996-09-01 00:00:00
