Abstract:
:The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhibited by preincubation of the cells with C3 and trypsin (15 min, 37 degrees C). However, the phagocytosis of opsonized yeast particles was not influenced by acceptor-bound C3b, proving that C3b-C3b acceptor interaction did not alter the function of C3b-receptors. Acceptor-bound C3b on the macrophages failed to mediate phagocytosis of human 0,Rh+ red cells having C3b-receptors.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Fábry Z,Erdei A,Gergely Jdoi
10.1016/0165-2478(83)90068-8subject
Has Abstractpub_date
1983-06-01 00:00:00pages
287-91issue
6eissn
0165-2478issn
1879-0542pii
0165-2478(83)90068-8journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.imlet.2017.12.008
更新日期:2018-02-01 00:00:00
abstract::The influence of human recombinant granulocyte-macrophage colony-stimulating factor (rH GM-CSF) on respiratory burst response of isolated human neutrophils was examined. Preincubation of cells with rH GM-CSF significantly increased the respiratory burst in response to formyl-methionyl-leucyl-phenylalanine (FMLP), meas...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90114-h
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.10.011
更新日期:2018-09-01 00:00:00
abstract::The antigen receptors on the surface of B- and T-lymphocytes are complexes of several integral membrane proteins, essential for their proper expression and function. Recent studies demonstrated that transmembrane (TM) domains of the components of these receptors play a critical role in their association and function. ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(98)00100-x
更新日期:1998-12-01 00:00:00
abstract::Thymocyte conditioned medium (TCM) was prepared using 2 lots of fetal calf, and 1 lot each of horse and rabbit sera. The 4 TCM and the respective sera alone were compared in their ability to support primary in vitro sensitization to sheep red blood cells (SRBC) as assayed by direct plaque formation. As would be expect...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90084-8
更新日期:1987-01-01 00:00:00
abstract::Between the ages of 2 to approximately 11 days mice respond to a challenge with syngeneic IgE by producing anti-IgE antibodies; by the age of 2 weeks they are unresponsive. Even adult mice, however, produce high titers of anti-IgE antibodies when immunized with a conjugate of syngeneic IgE and a foreign antigen such a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00087-3
更新日期:1995-09-01 00:00:00
abstract::Natural levels of goat antiphosphorylethanolamine (anti-PE) antibodies decreased after injection of purified human C-reactive protein (CRP). The concentration of anti-CRP antibodies followed a continuous increment from non-detectable levels to a plateau at 80 days after first injection. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90070-3
更新日期:1988-05-01 00:00:00
abstract::Even though IgA is considered to play an important role in immunity, surprisingly little is known about the presence of IgA Fc receptor (Fc alpha R)-expressing effector cells in tissues. Difficulties in obtaining human tissue macrophages, led us to study peritoneal macrophages in a human Fc alpha RI transgenic (Tg) mo...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00034-6
更新日期:1999-05-03 00:00:00
abstract::Rabbit anti-ovalbumin antibodies were found to bind to Swiss NIH 3T3 fibroblasts by indirect immunofluorescence, and to induce DNA synthesis when these cells were arrested in G0 phase of their replicating cycle (G0-S activity). The proof that these effects were related to the ovalbumin paratopes is based on the follow...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90069-1
更新日期:1987-05-01 00:00:00
abstract::Previous studies have demonstrated that culture supernatants of LPS-stimulated murine splenic B lymphocytes (BLPSSN) are able to inhibit the growth of freshly isolated B cells via an IgM antibody. In this work we investigated the progress of LPS-activated B lymphocytes through the cell cycle in the presence of this an...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90070-5
更新日期:1992-08-01 00:00:00
abstract::Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2019.01.006
更新日期:2019-11-01 00:00:00
abstract::Type I Diabetes mellitus (DM1) is the effect of T cell dependent autoimmune destruction of insulin producing beta cells in the pancreas islet. T cells are activated in response to islet dominant autoantigens, the result being the development of DM1. Insulin is one of the islet autoantigens responsible for activation o...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00309-6
更新日期:2001-01-15 00:00:00
abstract::We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of c...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00153-3
更新日期:1998-02-01 00:00:00
abstract::The phenomenon of virus neutralization is a function of three variables: the antibody (Ab), the virus and the target cell. Variation in any one of these parameters may drastically affect the results of assays for neutralization. In focusing on the virus as a variable in assays for the neutralization of HIV-1, it has b...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(96)02560-6
更新日期:1996-06-01 00:00:00
abstract::Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.09.026
更新日期:2013-11-01 00:00:00
abstract::Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycy...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90040-x
更新日期:1987-06-01 00:00:00
abstract::Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.imlet.2019.03.003
更新日期:2019-09-01 00:00:00
abstract::Both CD8 and CD2 are T cell surface receptors involved in physical cell interaction and in transmembrane signalling. The present paper addresses their role in the induction of two different functions of the cloned murine cytotoxic T cell C196: target cell lysis and IFN-gamma production. These functions were induced in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90018-6
更新日期:1991-10-01 00:00:00
abstract::An isogenic pair of virulent and avirulent Yersinia enterocolitica O9 strains was used to examine the influence of the virulence plasmid on the non-specific modification of the cellular immunity in BALB/c mice after experimental infection with yersiniae. The modification of contact hypersensitivity response to dinitro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)02481-6
更新日期:1996-01-01 00:00:00
abstract::ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(99)00024-3
更新日期:1999-05-03 00:00:00
abstract:UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.03.018
更新日期:2004-05-15 00:00:00
abstract::We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90197-x
更新日期:1990-01-01 00:00:00
abstract::Phagolysis of apoptotic eosinophils plays an important role in the successful resolution of asthmatic inflammation. However, little is known about underlying mechanisms. Our aim is to investigate whether annexin I is involved in the dexamethasone-mediated enhancement of phagolysis of apoptotic eosinophils by A549 cell...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2007.06.002
更新日期:2007-08-15 00:00:00
abstract::Two chicken monoclonal antibodies (MAbs), HU/Ch2-7 and HU/Ch6-1, against heterophil Hanganutziu-Deicher (HD) antigens with N-glycolylneuraminic acid (NeuGc) at a terminal carbohydrate were established by cell fusions using chicken B cell lines lacking thymidine kinase and spleen cells from chickens immunized with II3N...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90205-3
更新日期:1992-03-01 00:00:00
abstract::In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce co...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90115-q
更新日期:1991-05-01 00:00:00
abstract::HIV-1 positive patients generate Nef-specific CTL response, indicating that Nef is a potent immunogen. However, Nef is also known to down regulate the expression of CD4 and MHC-I molecules, thereby protecting virally infected target cells. We compared the immunogenicity of non-functional nef vaccine constructs to wild...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00141-x
更新日期:2003-10-31 00:00:00
abstract::Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.02.008
更新日期:2017-04-01 00:00:00
abstract::Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.017
更新日期:2014-12-01 00:00:00
abstract::Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90125-t
更新日期:1991-04-01 00:00:00
abstract::Autoimmune hepatitis (AIH) is a chronic liver disease mediated by immunity, and could lead to liver fibrosis and hepatocellular carcinoma. However, the mechanisms for breaking hepatic tolerance and driving AIH still remain elusive. We herein reported that the non-specific liver inflammation triggered by carbon tetrach...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.11.010
更新日期:2020-02-01 00:00:00