Autoreactivity in HIV-infected individuals does not increase during vaccination with envelope rgp160.


:The HIV-1 envelope protein contains several regions with amino acid homology to HLA class I and class II molecules. We evaluated possible changes in antibody responses to those regions during vaccination with rgp 160 produced in a baculovirus system. Forty asymptomatic HIV-infected patients with CD4 cell counts above 400 were vaccinated with rgp 160. Twenty-one patients were tissue-typed as HLA A2. Sixty-two percent of these patients exhibited cytotoxic lymphocyte antibodies directed to CD8+, HLA A2 cells. This cytotoxicity decreased during HIV gp160 vaccination. In order to further characterize the specificity of these responses, analogues of HLA class I and HLA-DR peptides were chemically synthesized together with their correct HIV-1 gp160 sequences. Enzyme-linked immunosorbent assays (ELISA) with sera from before, during and after immunization were performed with HIV proteins, peptides and their homologues. All patients showed an increase in their previously poor specific T-cell activation to gp160. Fourteen patients developed increased avidities or titres to HIV proteins and/or peptides. Contrarily, serum IgG titers to the HLA homologous peptides were initially low and decreased further during the course of vaccination. This decrease occurred in the majority of patients, 35-40 of the 40 individuals, depending on the antigen. Independent measures of autoantibodies to Ro/SS-A and La/SS-B remained undetectable.


Immunol Lett


Immunology letters


Lundholm P,Wahren M,Sandström E,Volvovitz F,Wahren B




Has Abstract


1994-07-01 00:00:00














  • FcgammaRI (CD64) resides constitutively in lipid rafts.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Beekman JM,van der Linden JA,van de Winkel JG,Leusen JH

    更新日期:2008-03-15 00:00:00

  • Quantitative effect of H-2-linked gene(s) on antibody response to human gamma-globulin.

    abstract::H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Heumann AM,Mouton D,Biozzi G

    更新日期:1982-11-01 00:00:00

  • Lack of CD24 expression in mice reduces the number of leukocytes in the colon.

    abstract::CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Bretz NP,Salnikov AV,Doberstein K,Garbi N,Kloess V,Joumaa S,Naumov I,Boon L,Moldenhauer G,Arber N,Altevogt P

    更新日期:2014-09-01 00:00:00

  • Hybridoma autoantibodies to erythrocytes from NZB mice and the induction of hemolytic anemia.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ozaki S,Nagasawa R,Sato H,Shirai T

    更新日期:1984-01-01 00:00:00

  • Cysticercosis: towards the design of a diagnostic kit based on synthetic peptides.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hernández M,Beltrán C,García E,Fragoso G,Gevorkian G,Fleury A,Parkhouse M,Harrison L,Sotelo J,Sciutto E

    更新日期:2000-01-10 00:00:00

  • J chain-positive cells in bursectomized chicks.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Moriya O,Ichikawa Y

    更新日期:1984-01-01 00:00:00

  • CD4 Th1 but not Th2 clones efficiently activate macrophages to eliminate Trypanosoma cruzi through a nitric oxide dependent mechanism.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Rodrigues MM,Ribeirão M,Boscardin SB

    更新日期:2000-07-03 00:00:00

  • Elimination of monocytes from cultures activated with recall antigens.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Pryjma J,Zembala M,Baran J,Ernst M,Flad HD

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Park SY,Lee SW,Baek SH,Lee SJ,Lee WS,Rhim BY,Hong KW,Kim CD

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  • Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Zsebik B,Citri A,Isola J,Yarden Y,Szöllosi J,Vereb G

    更新日期:2006-04-15 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Asadi G,Varmaziar FR,Karimi M,Rajabinejad M,Ranjbar S,Karaji AG,Salari F,Hezarkhani LA,Rezaiemanesh A

    更新日期:2021-01-25 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Raile A,Hammann KP,Scheiner O,Schulz T,Erdei A,Dierich MP

    更新日期:1982-06-01 00:00:00

  • Superior efficacy of dendritic cell-tumor fusion vaccine compared with tumor lysate-pulsed dendritic cell vaccine in colon cancer.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kao JY,Zhang M,Chen CM,Chen JJ

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ottó S

    更新日期:1983-04-01 00:00:00

  • Synergistic effect of prolactin on IFN-gamma-mediated growth arrest in human monoblastic cells: correlation with the up-regulation of IFN-gamma receptor gene expression.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Sedo A,Van Weyenbergh J,Rouillard D,Bauvois B

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  • Monoclonal antibodies against metallothioneins from the human liver.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Van Houdt K,Nicasi I,Van Mechelen E,Veulemans B,De Ley M

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  • Modification of macrophage response to lipopolysaccharide by fetuin.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Dziegielewska KM,Andersen NA,Saunders NR

    更新日期:1998-01-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Wysoczanska B,Bogunia-Kubik K,Suchnicki K,Mlynarczewska A,Lange A

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Brauweiler AM,Cambier JC

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Iwai H,Fernandes G

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    pub_type: 杂志文章


    authors: Silva BDS,Trentini MM,da Costa AC,Kipnis A,Junqueira-Kipnis AP

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Das MR,Gridley DS,Kettering JD

    更新日期:1991-09-01 00:00:00

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    abstract::Human natural killer (NK) cell activity was not significantly affected by leukotriene (LT) B4 over a wide concentration range (10(-6)-10(-14) M), whether added directly to the NK cell assay or after preincubation of effector cells for 2 h with the drug before addition of Cr labelled K562 target cells. In addition, LTB...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hall TJ,Brostoff J

    更新日期:1985-01-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Chi G,Pei JH,Ma QY,Ru YX,Feng ZH

    更新日期:2020-02-01 00:00:00

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    abstract::Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Zav'yalov VP,Denesyuk AI

    更新日期:1987-01-01 00:00:00

  • Variations of serum IgG subclass levels in hepatitis C virus infection during interferon-alpha therapy.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Musset L,Ghillani P,Lunel F,Cacoub P,Cresta P,Frangeul L,Rosenheim M,Preud'homme JL

    更新日期:1997-01-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Monastra G,Secchi EF

    更新日期:1993-10-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Rajashree P,Das SD

    更新日期:2008-05-15 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Wilson E,Walcheck B,Davis WC,Jutila MA

    更新日期:1998-11-01 00:00:00