当前位置： SCI文献检索 > IMMUNOLOGY LETTERS期刊下所有文献 > Type I interferons enhance production of IFN-gamma by NK cells.

Type I interferons enhance production of IFN-gamma by NK cells.

Abstract：

:In murine models, challenge with different viral and parasitic infection is closely associated with the production of type I interferons (IFN-alpha/beta) and NK cell production of interferon-gamma (IFN-gamma). Therefore, we wished to determine if IFN-alpha/beta had a role in the regulation of NK cell production of IFN-gamma. IFN-alpha/beta alone stimulated low levels of IFN-gamma production by purified populations of IL-2 activated NK cells but in combination with IL-12 resulted in the production of significant levels of IFN-gamma. Interestingly, maximal production of IFN-gamma by NK cells stimulated with IL-2 plus IFN-alpha/beta was dependent on endogenous tumor necrosis factor-alpha (TNF-alpha). Further studies revealed that TNF-alpha enhanced the ability of IFN-alpha/beta to stimulate production of IFN-gamma by NK cells. In contrast to the stimulatory effect of IFN-alpha/beta on NK cell production of IFN-gamma, IFN-alpha/beta inhibited IL-2 induced proliferation of NK cells. This inhibitory effect was not reversed by the addition of neutralizing antibodies specific for IFN-gamma or TNF-alpha. These data demonstrate that the type I interferons enhance NK cell production of IFN-gamma and suggest that they may be important in the regulation of NK cell production of IFN-gamma during infection.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Hunter CA,Gabriel KE,Radzanowski T,Neyer LE,Remington JS

doi

10.1016/s0165-2478(97)00091-6

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1-5

issue

1

eissn

0165-2478

issn

1879-0542

pii

S0165247897000916

journal_volume

59

pub_type

杂志文章

相关文献

IMMUNOLOGY LETTERS文献大全
  • Targeting PPAR ligands as possible approaches for metabolic reprogramming of T cells in cancer immunotherapy.

    abstract：:Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2020.01.006

    authors： Bahrambeigi S,Molaparast M,Sohrabi F,Seifi L,Faraji A,Fani S,Shafiei-Irannejad V

    更新日期：2020-04-01 00:00:00

  • Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO.

    abstract：:The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2012.06.005

    authors： Inostroza-Nieves Y,Venkatraman P,Zavala-Ruiz Z

    更新日期：2012-09-01 00:00:00

  • Effect of an autoreactive T cell clone from (NZB x NZW)F1 mice on the production of anti-DNA antibodies in vivo and in vitro.

    abstract：:An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(88)90175-7

    authors： Naiki M,Imai Y,Kamita Y,Osawa T

    更新日期：1988-08-01 00:00:00

  • Effect of IL-4 on peripheral blood lymphocyte proliferation: implication in immunopathogenesis of H. pylori infection.

    abstract：:Interleukin (IL) 4 is a type 2 cytokine which has a negative immunoregulatory role in human infection. IL-4 suppresses the production of interferon-gamma and enhances IL-10 synthesis. However, the effect of IL-4 on proliferative response of lymphocytes remains to be elucidated. We have previously reported an increase ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(95)02440-9

    authors： Fan XG,Yakoob J,Fan XJ,Keeling PW

    更新日期：1995-11-01 00:00:00

  • T-cell interactions with extracellular matrix proteins in periodontal disease.

    abstract：:Lymphoid cell infiltration of periodontal tissues undergoing pathological destruction suggests a functional interdependence between connective tissue proteins such as collagen, fibronectin and elastin and mononuclear cells, mainly T lymphocytes. The aim of the study was to assess T lymphocyte proliferation after stimu...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(98)00060-1

    authors： Słotwińska SM,Górski A,Wierzbicka M,Dybizbański E,Mrowiec T,Iwanicka-Frankowska E

    更新日期：1998-10-01 00:00:00

  • Innate lymphoid cells, precursors and plasticity.

    abstract：:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2016.07.004

    authors： Gronke K,Kofoed-Nielsen M,Diefenbach A

    更新日期：2016-11-01 00:00:00

  • Insight into lymphoid tissue morphogenesis.

    abstract：:Secondary lymphoid organs (SLO) are crucial structures for immune-surveillance and rapid immune responses allowing resident lymphocytes to encounter antigen-presenting cells that carry antigens from peripheral tissues. These structures develop during embryonic life through a tightly regulated process that involves int...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2013.08.001

    authors： Coles M,Veiga-Fernandes H

    更新日期：2013-11-01 00:00:00

  • Human T cell subsets differ in their ability to migrate in vitro and to produce T cell migration inhibitory factor.

    abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90122-7

    authors： Kowalczyk D,Pryjma J,Zembala M

    更新日期：1986-08-01 00:00:00

  • Effects of Helicobacter pylori infection on gastric inflammation and local cytokine production in histamine-deficient (histidine decarboxylase knock-out) mice.

    abstract：UNLABELLED:Helicobacter pylori infection in humans causes gastritis. The infection elicits a complex immune response in which the activation of mast cells and histamine release is of particular importance. Histamine further promotes the immune response and stimulates gastric acid secretion. The inflammatory effects of ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2004.05.005

    authors： Klausz G,Buzás E,Scharek P,Tiszlavicz L,Gyulai Z,Fülöp AK,Falus A,Mándi Y

    更新日期：2004-07-15 00:00:00

  • The human Fc receptor for IgA (Fc alpha RI, CD89) on transgenic peritoneal macrophages triggers phagocytosis and tumor cell lysis.

    abstract：:Even though IgA is considered to play an important role in immunity, surprisingly little is known about the presence of IgA Fc receptor (Fc alpha R)-expressing effector cells in tissues. Difficulties in obtaining human tissue macrophages, led us to study peritoneal macrophages in a human Fc alpha RI transgenic (Tg) mo...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(99)00034-6

    authors： van Egmond M,Hanneke van Vuuren AJ,van de Winkel JG

    更新日期：1999-05-03 00:00:00

  • Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles.

    abstract：:Neuraminidases act as a virulence factors for several pathogens that invade the human body through Peyer's patch M-cells. Because of the structural similarity of Aleuria aurantia lectin (AAL) to neuraminidases, we hypothesized that AAL might also target human M-cells. In an in vitro human M-cell co-culture model signi...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.03.020

    authors： Roth-Walter F,Bohle B,Schöll I,Untersmayr E,Scheiner O,Boltz-Nitulescu G,Gabor F,Brayden DJ,Jensen-Jarolim E

    更新日期：2005-09-15 00:00:00

  • Predicted secondary structure and hydrophobic cores of T-cell (TCGF or IL-2) and platelet-derived growth factors as well as of transforming protein p28sis of simian sarcoma virus are similar to those of interferons.

    abstract：:Estimation of a content of secondary structures from amino acid composition of IL-2 (TCGF), PDGF and transforming protein p28sis of simian sarcoma virus by means of the previously suggested nomograms (V.P. Zav'yalov and A.I. Denesyuk (1982) Immunol. Lett. 4, 7-14) allowed us to conclude that a dominant secondary struc...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(85)90178-6

    authors： Zav'yalov VP,Denesyuk AI

    更新日期：1985-01-01 00:00:00

  • HIV and human complement: inefficient virolysis and effective adherence.

    abstract：:Both, HIV envelope proteins gp120 and gp41 can directly activate complement system, even in the absence of HIV-specific antibodies. During the budding process HIV acquires host membrane-associated molecules among these complement regulatory proteins (CRPs). The presence of CRPs on the viral surface rescues HIV from co...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2004.11.007

    authors： Bánki Z,Stoiber H,Dierich MP

    更新日期：2005-03-15 00:00:00

  • Benazepril inhibited the NF-κB and TGF-β networking on LV hypertrophy in rats.

    abstract：PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.05.005

    authors： Yan SH,Zhao NW,Zhu XX,Wang Q,Wang HD,Fu R,Sun Y,Li QY

    更新日期：2013-05-01 00:00:00

  • Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.

    abstract：:Cell surface molecules are present on several lymphocyte subsets and are differentially expressed during lymphocyte development and activation. Human Leukocyte Differentiation Antigen (HLDA) Workshops have played an essential role in the identification and characterization of the molecules found in the membrane of hem...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2010.10.009

    authors： Llinàs L,Lázaro A,de Salort J,Matesanz-Isabel J,Sintes J,Engel P

    更新日期：2011-01-30 00:00:00

  • Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.

    abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective way to cure hematological malignancies. However, graft-versus-host disease (GVHD) following transplantation limits the clinical application to some extent. The donor T lymphocytes play a central role in the occurrence and development of GVH...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2011.01.010

    authors： Sang W,Zhou C,Cheng N,Li Z,Zeng L,Xu K

    更新日期：2011-05-01 00:00:00

  • Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: a unique landscape of innate immunity.

    abstract：:Pathogens in general and pathogenic viruses in particular have evolved a myriad of mechanisms to escape the immune response of mammalian species. Viruses that cause acute disease tend to bear characteristics that make them very contagious, as survival does not derive from chronicity of infection, but spread of disease...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2013.05.007

    authors： Toka FN,Golde WT

    更新日期：2013-05-01 00:00:00

  • Increased expression of C1-inhibitor mRNA in patients with hereditary angioedema treated with Danazol.

    abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(03)00029-4

    authors： Pappalardo E,Zingale LC,Cicardi M

    更新日期：2003-05-01 00:00:00

  • Quantitative effect of H-2-linked gene(s) on antibody response to human gamma-globulin.

    abstract：:H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(82)90111-0

    authors： Heumann AM,Mouton D,Biozzi G

    更新日期：1982-11-01 00:00:00

  • Th1 and Th2 cytokine profiles induced by hepatitis C virus F protein in peripheral blood mononuclear cells from chronic hepatitis C patients.

    abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.05.002

    authors： Yue M,Deng X,Zhai X,Xu K,Kong J,Zhang J,Zhou Z,Yu X,Xu X,Liu Y,Zhu D,Zhang Y

    更新日期：2013-05-01 00:00:00

  • Use of antibody gene library for the isolation of specific single chain antibodies by ampicillin-antigen conjugates.

    abstract：:Isolation of recombinant antibodies from antibody libraries is commonly performed by different molecular display formats including phage display and ribosome display or different cell-surface display formats. We describe a new method which allows the selection of Escherichia coli cells producing the required single ch...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.02.005

    authors： Neumann-Schaal M,Messerschmidt K,Grenz N,Heilmann K

    更新日期：2013-03-01 00:00:00

  • Autocrine regulation of ICAM-1 expression on bladder cancer cell lines: evidence for the role of IL-1 alpha.

    abstract：:We have studied the autocrine regulation of essential expression of the intercellular adhesion molecule-1 (ICAM-1) on 8 transitional cell carcinoma (TCC) cell lines (histopathological grades 1-3). The constitutive expression of ICAM-1 was regulated by soluble factors in an autocrine fashion. These factors were produce...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)90182-1

    authors： Alexandroff AB,Jackson AM,Esuvaranathan K,Prescott S,James K

    更新日期：1994-05-01 00:00:00

  • Identification of the polymorphisms in IFITM1 gene and their association in a Korean population with ulcerative colitis.

    abstract：:Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.09.026

    authors： Mo JS,Na KS,Yu JI,Chae SC

    更新日期：2013-11-01 00:00:00

  • High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice.

    abstract：:It remains unclear whether lipopolysaccharide (LPS) pre-treatment, which prevents Th2-type responses via Toll-like receptor 4 (TLR4), inhibits anaphylaxis. To determine the dose-dependent effects of LPS pre-treatment on anaphylactic decreases in rectal temperature caused by ovalbumin (OVA) re-exposure in immunized mic...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2008.03.001

    authors： Shiva D,Matsumoto T,Kremenik MJ,Kato Y,Yano H

    更新日期：2008-06-15 00:00:00

  • Identification of CD244-expressing myeloid-derived suppressor cells in patients with active tuberculosis.

    abstract：:Development of active TB is accompanied by immune suppression and the underlining mechanisms have been explored extensively in recent years. MDSCs are a heterogeneous group of immature and progenitor myeloid cells with strong immunosuppressive ability for both natural and adaptive immunity. In our analysis of CD244 (2...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.12.003

    authors： Yang B,Wang X,Jiang J,Zhai F,Cheng X

    更新日期：2014-03-01 00:00:00

  • Study of interaction between L-glutamate and human blood lymphocytes.

    abstract：:The presence of specific glutamate receptors on T lymphocytes separated from normal human blood was investigated. Upon study of T lymphocytes interaction with [3H]glutamate the last one was found to bind specifically to these cells, Kd = 2.36 x 10(-7) M. Thirteen unlabelled compounds were tested as potential glutamate...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(97)00086-2

    authors： Kostanyan IA,Merkulova MI,Navolotskaya EV,Nurieva RI

    更新日期：1997-08-01 00:00:00

  • MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis.

    abstract：:Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an effective immune response against TB, (ii) MyD88 is essential, but not because it transduces signals from TLRs, (iii) adaptive immunity...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2007.11.015

    authors： Reiling N,Ehlers S,Hölscher C

    更新日期：2008-02-15 00:00:00

  • Infectivity of Leishmania promastigotes is associated with surface antigenic expression.

    abstract：:Differentiation between a non-infective and an infective Leishmania promastigote population was demonstrated. Promastigotes in the stationary phase (day 5) were found to be highly infective in vitro to BALB/c mouse peritoneal macrophages, compared with those of the logarithmic phase (day 3). The infective promastigote...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(85)90114-2

    authors： Rizvi FS,Afchain D,Sherlock I,Sadigursky M,Capron A,Santoro F

    更新日期：1985-01-01 00:00:00

  • Changes in the acute phase complement component and IL-6 levels in patients with chronic hepatitis C receiving interferon alpha-2b.

    abstract：:In order to study the effect of interferon alpha on the levels of acute phase complement proteins in vivo, serum concentrations of C9 and C1-inhibitor (C1-INH) were measured in patients with chronic hepatitis C before and 3 months after the beginning of interferon alpha2b therapy. Serum levels of the activation produc...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(00)00183-8

    authors： Bíró L,Varga L,Pár A,Nemesánszky E,Csepregi A,Telegdy L,Ibrányi E,Dávid K,Horváth G,Szentgyörgyi L,Nagy I,Dalmi L,Abonyi M,Füst G,Horányi M

    更新日期：2000-05-01 00:00:00

  • Potential role of the mannose receptor in antigen transport.

    abstract：:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(98)00117-5

    authors： Martínez-Pomares L,Gordon S

    更新日期：1999-01-01 00:00:00