Abstract:
:The question is still unresolved whether in insulin-dependent (type I) diabetes T-lymphocytes mediate an autoimmune response towards pancreatic islets. We now present direct evidence in an animal model for autoimmune T-lymphocytes with specificity for islet antigens. Mice of strain C57BL/6 were immunized repeatedly with islet homogenates. Lymphocytes isolated from draining lymph nodes and the spleen show a specific proliferative response when challenged with mouse rat or islet antigens but do not respond to liver or spleen antigens. Islet antigen specific lymphoblasts have been maintained by in vitro culture for several weeks in the presence of T-cell growth factor containing medium.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Kolb H,Ben-Nun A,Cohen IR,Barberena I,Kiesel Udoi
10.1016/0165-2478(85)90090-2subject
Has Abstractpub_date
1985-01-01 00:00:00pages
29-32issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(85)90090-2journal_volume
9pub_type
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更新日期:2003-01-02 00:00:00
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journal_title:Immunology letters
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