Abstract:
:The thymus contains a low frequency of B cells, about 0.1-0.5% of total population of thymocytes that were shown to contribute in thymic negative selection. The fact that B cells in the periphery have been contributed in the generation of the T regulatory cell compartment emerged the idea that this process may indeed be initiated firstly within the thymus. The results of this study revealed that activated thymic B cells maintained the high percentage of nTreg generation or counteracted the decrease of this percentage observed in non-activated culture, and both activators (LPS and IMQ) have the same effect in the process of nTreg generation by B cells. In addition, the activated cultures showed increase of the level of expression of Foxp3 transcription factor. In this study we confirmed that thymic B cells in the condition of our experiments did not influence the generation of nTregs, but rather maintain their viability when activated by both activators.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Mohammed Ali HH,Drela Ndoi
10.1016/j.imlet.2017.03.007subject
Has Abstractpub_date
2017-05-01 00:00:00pages
56-63eissn
0165-2478issn
1879-0542pii
S0165-2478(16)30289-9journal_volume
185pub_type
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