A monoclonal antibody to CD11c antigen inhibits the production of superoxide anion induced by concanavalin A in PMA-differentiated U-937 cells.

abstract：:A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i...

journal_title：Immunology letters

authors： Scarlatti G,Leitner T,Hodara V,Jansson M,Karlsson A,Wahlberg J,Rossi P,Uhlén M,Fenyö EM,Albert J

更新日期：1996-06-01 00:00:00

abstract：:Using the method of estimation of alpha-helical and beta-folded types of secondary structure from amino acid composition, it has been established that interferons contain about 60-70% of alpha-helices and not more than 10-20% of beta-structure. The same result was obtained using empirical and stereochemical rules for ...

journal_title：Immunology letters

authors： Zav'yalov VP,Denesyuk AI

更新日期：1982-01-01 00:00:00

abstract：:Partially purified IgE receptor(s) of rat basophilic leukemia cells (RBL) designated R and H and having apparent molecular weight of 45,000 and 55,000 daltons, respectively, were subjected to proteolysis with papain. Polyacrylamide gel electrophoresis of the digests in the presence of sodium dodecyl sulfate revealed a...

journal_title：Immunology letters

authors： Roth PA,Froese A

更新日期：1982-03-01 00:00:00

abstract：:The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...

journal_title：Immunology letters

authors： Choremi-Papadopoulou E,Faure GC,Malenica B,Misbah SA,Zlabinger GJ

更新日期：2009-06-30 00:00:00

abstract：:During a pathogenic infection, an inflammatory process is triggered in which several inflammatory mediators, such as cytokines, chemokines, growth factors, complement system components, nitric oxide, and others induce integrity alteration on the endothelial barrier. Chemokines are responsible for regulating leukocyte ...

journal_title：Immunology letters

authors： Cipitelli MDC,Amâncio Paiva I,Badolato-Corrêa J,de-Oliveira-Pinto LM

更新日期：2019-08-01 00:00:00

abstract：:In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...

journal_title：Immunology letters

authors： Bellora F,Castriconi R,Dondero A,Carrega P,Mantovani A,Ferlazzo G,Moretta A,Bottino C

更新日期：2014-10-01 00:00:00

abstract：:Pentoxifylline (PTX), a methylxanthine derivative and phosphodiesterase inhibitor, is known to influence production and/or function of some cytokines. We examined the effect of PTX on the in vitro expression of cytokine genes using endotoxin- or phytohaemagglutinin (PHA)-stimulated human blood mononuclear cells. The e...

journal_title：Immunology letters

authors： Rieneck K,Diamant M,Haahr PM,Schönharting M,Bendtzen K

更新日期：1993-08-01 00:00:00

abstract：:Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance...

journal_title：Immunology letters

authors： Gougeon ML,Lecoeur H,Sasaki Y

更新日期：1999-03-01 00:00:00

abstract：:When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...

journal_title：Immunology letters

authors： Malbec O,Daëron M

更新日期：2012-03-30 00:00:00

abstract：:Isolated inherited deficiency states of almost every complement protein have been recognized. Almost all are autosomal recessive traits. Deficiency of the early-acting components C1, C4 and C2 is associated with increased risk of immune complex disease, particularly systemic lupus erythematosus. Patients with deficien...

journal_title：Immunology letters

authors： Alper CA

更新日期：1987-02-01 00:00:00

abstract：:A new method of panning for B lymphocytes is described in which the ability of the sIg+ cells to adhere depends on the nature and concentration of nonspecific protein used rather than on the use of anti-immunoglobulin. Rat lymph node cells were suspended in 3% bovine serum albumin in Tris-buffered Hanks' and incubated...

journal_title：Immunology letters

authors： Severson CD,Burg DL,Lafrenz DE,Feldbush TL

更新日期：1987-08-01 00:00:00

abstract：:A direct role for delayed hypersensitivity in organized granuloma formation has been emphasized in the literature, but some clinical and experimental studies have suggested a more complicated relationship. In order to further evaluate T-cell function in cutaneous granulomatous inflammation, hepatic granulomas isolated...

journal_title：Immunology letters

authors： Epstein WL,Okamoto M,Suya H,Fukuyama K

更新日期：1986-11-17 00:00:00

abstract：:Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characteriz...

journal_title：Immunology letters

authors： Napoli C,Benincasa G,Criscuolo C,Faenza M,Liberato C,Rusciano M

更新日期：2021-01-06 00:00:00

abstract：:The thymus contains a low frequency of B cells, about 0.1-0.5% of total population of thymocytes that were shown to contribute in thymic negative selection. The fact that B cells in the periphery have been contributed in the generation of the T regulatory cell compartment emerged the idea that this process may indeed ...

journal_title：Immunology letters

authors： Mohammed Ali HH,Drela N

更新日期：2017-05-01 00:00:00

abstract：:This study aimed to investigate the influence of physical activity in innate immunity to conduce to an effective antitumoral immune response analyzing the phenotype and activation status of infiltrating cells. We analysed the intracellular cytokines and the transcription factors of tumor infiltrating lymphocytes (TILS...

journal_title：Immunology letters

authors： Bianco TM,Abdalla DR,Desidério CS,Thys S,Simoens C,Bogers JP,Murta EFC,Michelin MA

更新日期：2017-10-01 00:00:00

abstract：:IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting with a previously isolated cDNA clone encoding human gp130, recombinant soluble gp130 (sgp130) lacking the transmembrane and cytoplasmic r...

journal_title：Immunology letters

authors： Yasukawa K,Futatsugi K,Saito T,Yawata H,Narazaki M,Suzuki H,Taga T,Kishimoto T

更新日期：1992-02-01 00:00:00

abstract：:Multiple antigen peptides (MAP), consisting of a number of peptide copies synthesized on a branching lysyl core, offer a novel approach for rendering small peptides immunoreactive in solid-phase immunoassays. An octameric MAP, carrying 6 repeats of the sequence -N-A-A-G-, tandem repeated in the immunodominant region o...

journal_title：Immunology letters

authors： Habluetzel A,Pessi A,Bianchi E,Rotigliano G,Esposito F

更新日期：1991-09-01 00:00:00

abstract：:Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...

journal_title：Immunology letters

authors： Rossi GA,Peri C,Raynal ME,Defilippi AC,Risso FM,Schenone G,Pallestrini E,Melioli G

更新日期：2003-03-03 00:00:00

abstract：:HIV-1 positive patients generate Nef-specific CTL response, indicating that Nef is a potent immunogen. However, Nef is also known to down regulate the expression of CD4 and MHC-I molecules, thereby protecting virally infected target cells. We compared the immunogenicity of non-functional nef vaccine constructs to wild...

journal_title：Immunology letters

authors： Majumder B,Gray B,McBurney S,Schaefer TM,Dentchev T,Mahalingam S,Reinhart TA,Ayyavoo V

更新日期：2003-10-31 00:00:00

abstract：:The previously called "hemoglobinase" Sm32 molecule of the adult worm of Schistosoma mansoni was chemically synthesized in 22 polymeric peptides based on the t-boc strategy. Their immunogenicity was evaluated in rabbits to which a mixture of five to six peptides of 20 amino acids long were given in three doses with Fr...

journal_title：Immunology letters

authors： Noya O,Alarcón de Noya B,Guzmán F,Bermúdez H

更新日期：2003-09-08 00:00:00

abstract：:The Nramp1 gene was originally described as Ity/Lsh/Bcg, a single gene controlling resistance and susceptibility of inbred mice to a range of intramacrophage pathogens. Functional studies demonstrated that Ity/Lsh/Bcg had multiple pleiotropic effects on macrophage activation pathways, broadening interest in the gene t...

journal_title：Immunology letters

authors： Blackwell JM,Searle S

更新日期：1999-01-01 00:00:00

abstract：:Coelomic fluid from the earthworm Lumbricus terrestris is known to contain immunoactive cells and molecules involved in immune defense. To assess the ability of such molecules to form precipitating complexes with anti-human immunoglobulins, radial immunodiffusion experiments were conducted. Anti-human IgG, anti-human ...

journal_title：Immunology letters

authors： Eyambe GS

更新日期：1993-02-01 00:00:00

abstract：:Mimotopes derived from peptide phage display libraries may reproduce basic functions of epitopes including their antigenicity. In case of toxins, this property makes phage displayed mimotopes highly specific vaccine components free of the toxicity. To explore the potential of mimotopes for vaccine development, their a...

journal_title：Immunology letters

authors： Hernández R,Gazarian TG,Hérion PS,Gazarian KG

更新日期：2002-02-01 00:00:00

abstract：:A considerable body of evidence from various laboratories indicates that specific T cell responses generated during infection with Leishmania parasites play an important role both in the resolution and progression of cutaneous leishmaniasis. Recent data, summarized in this article, indicate that resolution of lesions ...

journal_title：Immunology letters

authors： Müller I,Pedrazzini T,Louis JA

更新日期：1988-11-01 00:00:00

abstract：:Antigen receptor (AgR) crosslinking by antigens or AgR-specific antibodies induces a cascade of enzymatic events in lymphocytes which involves activation of several non-receptor tyrosine- and serine/threonine kinases, phosphatases, phospholipases, etc. Here we show data demonstrating that a thiol group-reactive protei...

journal_title：Immunology letters

authors： Rozsnyay Z,Sarmay G,Gergely J

更新日期：1993-08-01 00:00:00

abstract：:There is increasing evidence for the role of basophils in allergic bronchial asthma. We studied the potential role of basophils in the pathogenesis of post-exercise-induced bronchoconstriction by measuring the histamine release from basophils both spontaneously and following ConA, FMLP, anti-IgE and TPA treatment. Two...

journal_title：Immunology letters

authors： Kivity S,Schwarz I,Agami O,Topilsky M,Fireman E

更新日期：1994-09-01 00:00:00

abstract：:Classical swine fever (CSF) and pseudorabies (PR) are both major infectious diseases of pigs, causing enormous economic losses to the swine industry in many countries. A marker vaccine that enables differentiation of infected from vaccinated animals (DIVA) is highly desirable for control and eradication of these two d...

journal_title：Immunology letters

authors： Lei JL,Xia SL,Wang Y,Du M,Xiang GT,Cong X,Luo Y,Li LF,Zhang L,Yu J,Hu Y,Qiu HJ,Sun Y

更新日期：2016-06-01 00:00:00

abstract：:Lymphoid cell infiltration of periodontal tissues undergoing pathological destruction suggests a functional interdependence between connective tissue proteins such as collagen, fibronectin and elastin and mononuclear cells, mainly T lymphocytes. The aim of the study was to assess T lymphocyte proliferation after stimu...

journal_title：Immunology letters

authors： Słotwińska SM,Górski A,Wierzbicka M,Dybizbański E,Mrowiec T,Iwanicka-Frankowska E

更新日期：1998-10-01 00:00:00

abstract：:The effect of B cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. Thirteen CBA mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse Ig antibody from 24 hours to 8 weeks after birth. Controls were given normal rabbit IgG (...

journal_title：Immunology letters

authors： Rayfield LS,Smith TA,Andrews SJ,Bergmeier LA

更新日期：1989-01-15 00:00:00

abstract：:The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...

journal_title：Immunology letters

authors： Pereira-da-Silva G,Roque-Barreira MC,Van Damme EJ

更新日期：2008-08-15 00:00:00