Abstract：
:A series of nor-MDP analogues were evaluated for adjuvanticity in rodents using beta hCG-TT conjugate as the antigen. Of these, one compound, N-acetylnor-muramyl-L-N-methylalanyl-D-isoglutamine octylamide (nor-MDP octylamide (N-Me-Ala] was found to be effective. This compound, formulated with beta hCG-TT in water-in-oil emulsion and administered to rodents, significantly enhanced the anti-hCG response. The anti-hCG titers induced were three-fold higher than that of control formulation. Moreover, inclusion of this compound in the first injection only gave adequate levels of antibodies to the hormone which persisted longer in the blood circulation. Effectiveness of antibodies in neutralizing hCG was tested in vitro by the mouse Leydig cell bioassay. Biological vs. immunological binding capacities (B/I ratio) were compared. The results suggest that nor-MDP octylamide (N-Me-Ala) will be useful as an adjuvant for human vaccines.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Alam A,Capoor AK,Rao LVdoi
10.1016/0165-2478(91)90244-5subject
Has Abstractpub_date
1991-01-01 00:00:00pages
53-7issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(91)90244-5journal_volume
27pub_type
杂志文章abstract：:The mechanism of cytolysis by natural killer cells has been shown to involve a soluble lytic factor - the natural killer cytotoxic factor (NKCF). We have investigated the generation of NKCF on exposure of subpopulations of human blood lymphocytes to autologous B lymphocytes and EBV infected B lymphocytes (BEBV), and t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90096-9
更新日期：1986-03-01 00:00:00
abstract：:Experiments with malaria in mice suggest that protective immunity depends not only on antibody but also on activation of macrophages. Activated macrophages may cause intra-erythrocytic death of parasites by releasing reactive oxygen intermediates and/or tumour necrosis factor. Macrophage activation for both types of p...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(85)90173-7
更新日期：1985-01-01 00:00:00
abstract：:Immunoglobulin species, recombined from Fab and Fc fragments with anti-red cell specificity were used as cytophilic antibodies in studies of triggering the effector activity of immunoglobulins. Recombinant immunoglobulins containing a single Fab' appeared inactive in binding to cell receptors and triggering antibody d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90046-4
更新日期：1984-01-01 00:00:00
abstract：:A consensus motif for a bovine major histocompatibility complex (MHC) class I molecule, A20, was derived from parainfluenza type-3 (PI-3) virus-infected muscle-derived fibroblast cells and peripheral blood leukocytes by extraction of the naturally processed peptides from MHC class I molecules by treatment with TFA and...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00244-l
更新日期：1995-02-01 00:00:00
abstract：:Homogeneous IgG fractions were obtained by chromatography of the sera of patients with multiple sclerosis (MS) on Protein G-Sepharose under conditions that remove non-specifically bound proteins. These IgGs contained several chelated metals, the relative amount of which decreases in the order: Fe>or=Ca>Cu>or=Zn>or=Mg>...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.018
更新日期：2006-02-28 00:00:00
abstract：:Flt3 ligand, a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Its potential use in a clinical setting has been suggested. Here, we studied the effect of in situ delivery of Flt3 ligand plasmid (FL) on the antibody resp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00039-1
更新日期：2002-05-01 00:00:00
abstract：:Members of the transforming growth factor beta (TGF-beta) superfamily are soluble factors that regulate a variety of functional responses including proliferation, differentiation, apoptosis and cell cycle, among others, depending not only on the cell type and its differentiation state, but also on the milieu of cytoki...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2006.12.010
更新日期：2007-03-15 00:00:00
abstract：:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90056-7
更新日期：1984-01-01 00:00:00
abstract：:Interleukin 2 (IL 2) is a lymphocyte growth factor capable of inducing the rapid growth of antigen- or mitogen-stimulated T cells. To understand the molecular mechanisms of IL 2 action, we studied the synthesis of cellular polypeptides induced by IL 2. For a homogeneous cell population responsive to IL 2, we used a mu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90115-4
更新日期：1985-01-01 00:00:00
abstract：:Screening of expression cDNA libraries derived from human neoplasms with autologous sera (SEREX) is an established method for defining antigens immunogenic in individual cancer patients. Although the majority of SEREX-derived cDNA clones encode autoantigens, some of them represent shared cancer antigens with cancer-re...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00209-2
更新日期：2003-01-02 00:00:00
abstract：:The monoclonal antibody 3A35 which binds mouse polymorphonuclear leucocytes (PMN) and monocytes was injected intravenously (i.v.) into normal mice. A great diminution of circulating PMN was observed. The percentage of PMN passed through a minimum (2.5%) 20 min after antibody injection and returned to normal value (18....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90048-3
更新日期：1985-01-01 00:00:00
abstract：:Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (o...
journal_title：Immunology letters
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.imlet.2017.07.014
更新日期：2017-10-01 00:00:00
abstract：:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90069-2
更新日期：1989-01-15 00:00:00
abstract：:Indoleamine 2,3-dioxygenase (IDO) is an enzyme with an immunosuppressive effect whose function is diverted by tumor cells to counteract immune cell functions, inducing immune escape of tumor cells. The aim of this study was to investigate the clinical significance of IDO in nasopharyngeal carcinoma (NPC). Compared to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.11.012
更新日期：2016-01-01 00:00:00
abstract：:Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4+CD25bri regulatory ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.009
更新日期：2017-01-01 00:00:00
abstract：:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00085-j
更新日期：1995-07-01 00:00:00
abstract：:Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the presen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.03.012
更新日期：2018-06-01 00:00:00
abstract：:Two crucial mediators of monocyte activation by lipopolysaccharide (LPS) are the acute phase plasma factor, lipopolysaccharide binding protein (LBP) and cell-surface-expressed CD14. Whether macrophage (M phi) recognized and respond to LPS in a similar manner is unknown. Here we show that human monocyte-derived M phi r...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02645-4
更新日期：1996-12-01 00:00:00
abstract：:Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90010-y
更新日期：1993-11-01 00:00:00
abstract：:Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice conta...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90092-3
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...
journal_title：Immunology letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.imlet.2017.12.008
更新日期：2018-02-01 00:00:00
abstract：:In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(91)90213-t
更新日期：1991-07-01 00:00:00
abstract：:Estimation of a content of secondary structures from amino acid composition of IL-2 (TCGF), PDGF and transforming protein p28sis of simian sarcoma virus by means of the previously suggested nomograms (V.P. Zav'yalov and A.I. Denesyuk (1982) Immunol. Lett. 4, 7-14) allowed us to conclude that a dominant secondary struc...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90178-6
更新日期：1985-01-01 00:00:00
abstract：:The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was to establish the time-dependent relation between plasma cytokines interleukin (IL)-10, transforming growth factor (TGF)-beta1, ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.07.009
更新日期：2004-09-01 00:00:00
abstract：:Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephe...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02522-9
更新日期：1996-05-01 00:00:00
abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein expressed by rat mast cells and basophils. MAFA clustering by its specific monoclonal antibody, (mAb) G63, efficiently inhibits the FcvarepsilonRI induced secretory response of mucosal-type mast cells of the RBL-2H3 line, as well as b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00013-5
更新日期：2002-06-03 00:00:00
abstract：:Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90003-1
更新日期：1981-11-01 00:00:00
abstract：:As the most common non-traumatic disabling disease among adolescents, multiple sclerosis (MS) is a devastating neurological inflammatory disease of the central nervous system. Research has not yet fully elucidated its pathogenesis, but it has shown MS to be a complex, multifactorial disease with many interplaying fact...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.02.012
更新日期：2020-06-01 00:00:00
abstract：:Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cel...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.09.010
更新日期：2006-03-15 00:00:00
abstract：:SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90102-1
更新日期：1986-03-01 00:00:00
