Immune activation in non-treated suicidal major depression.

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by the selective destruction of the insulin-producing β cells. Research into the pathogenesis of T1D has been hindered by the lack of detection of the autoimmune process during the asymptomatic period and by the inaccessibility to the target tissue. Therefore curre...

journal_title：Immunology letters

authors： Planas R,Pujol-Borrell R,Vives-Pi M

更新日期：2010-10-30 00:00:00

abstract：:Numerous studies have dealt with occurrence of dendritic cells in various nonlymphoid organs such as kidney, liver or heart, whereas lymphocyte patterns in these organs have not been analyzed in detail. In the present study, leukocytes were quantified as cells/mm2 in the perivascular, interstitial and parenchymal tiss...

journal_title：Immunology letters

authors： Holzinger C,Zuckermann A,Reinwald C,Imhof M,Schöllhammer A,Kramer G,Wolner E,Steiner G

更新日期：1996-11-01 00:00:00

abstract：:Callithrix jacchus, the common marmoset, is a small new world primate that is considered effective as an experimental animal model for various human diseases. In this study, we generated monoclonal antibodies (mAbs) against common marmoset lymphocytes for immunological studies on the common marmoset. We established fi...

journal_title：Immunology letters

authors： Ito R,Maekawa S,Kawai K,Suemizu H,Suzuki S,Ishii H,Tanioka Y,Satake M,Yagita H,Habu S,Ito M

更新日期：2008-12-22 00:00:00

abstract：:An essential key to pathogenicity in Yersinia is the presence of a 70 kb plasmid (pYV) which encodes a type-III secretion system and several virulence outer proteins whose main function is to enable the bacteria to survive in the host. Thus, a specific immune response is needed in which cytokines are engaged. The aim ...

journal_title：Immunology letters

authors： Monnazzi LG,Carlos IZ,de Medeiros BM

更新日期：2004-06-15 00:00:00

abstract：:Dendritic cells (DCs) differentiated in the presence of IL-10 preferentially induce regulatory T-cells and tolerance. Whether the tolerogenic properties displayed by these DCs (Tol-DCs) can be overcome has not been fully explored. Here we show for the first time that Tol-DCs express higher levels of TLR5 mRNA, but not...

journal_title：Immunology letters

authors： Vicente-Suarez I,Brayer J,Villagra A,Cheng F,Sotomayor EM

更新日期：2009-08-15 00:00:00

abstract：:NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signallin...

journal_title：Immunology letters

authors： Trevelin SC,Shah AM,Lombardi G

更新日期：2020-05-01 00:00:00

abstract：:Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...

journal_title：Immunology letters

authors： Hojo H,Kaneko A,Nanya K,Kayagaki N,Hashimoto Y

更新日期：1994-06-01 00:00:00

abstract：:Adult B-acute lymphoblastic leukemia (B-ALL) does not share the favorable prognosis seen in pediatric patients with the same disease. Less than 50% of patients experience long-term survival and for those adults over age 60, long-term survival is only 10%. At time of relapse, 5-year prognosis is a dismal 7%. Novel and ...

journal_title：Immunology letters

authors： Sikaria S,Aldoss I,Akhtari M

更新日期：2016-04-01 00:00:00

abstract：:Circulating lymphocytes were enumerated in 25 patients with coeliac disease and in 24 healthy donors by immunofluorescent staining using monoclonal antibodies for T cell surface phenotypic markers T11 (mature), T4 (helper) and T8 (suppressor) or polyvalent antisera for surface immunoglobulins (B cells). Proportions of...

journal_title：Immunology letters

authors： Vĕtvicka V,Tlaskalová-Hogenová H,Fric P,Brochier J

更新日期：1986-08-01 00:00:00

abstract：:CD103(+)CD11b(+) dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103(+)CD11b(+) DC...

journal_title：Immunology letters

authors： Fernández-Santoscoy M,Wenzel UA,Persson E,Yrlid U,Agace W,Wick MJ

更新日期：2016-08-01 00:00:00

abstract：:The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhib...

journal_title：Immunology letters

authors： Fábry Z,Erdei A,Gergely J

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Infantile hemangiomas (IHs) are the most common benign tumors of childhood. They are characterized by a unique clinical course with two phases, proliferation and involution, which are followed by regression. The therapy of infantile hemangiomas was revolutionized in 2008 by the introduction of propranolol, h...

journal_title：Immunology letters

authors： Wnęk A,Andrzejewska E,Kobos J,Taran K,Przewratil P

更新日期：2017-05-01 00:00:00

abstract：:Administration of opioids that bind to the classical mu opioid receptor has been shown to lead to unintended alterations in immune function. Traditionally, altered immune function has been investigated with circulating immune cells. Effects of mu agonists on intestinal epithelial immune function have not been describe...

journal_title：Immunology letters

authors： Neudeck BL,Loeb JM

更新日期：2002-12-03 00:00:00

abstract：:Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, di...

journal_title：Immunology letters

authors： Gao P,Mu M,Chen Y,He J,Tao X,Song C

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...

journal_title：Immunology letters

authors： Chen Y,McKenna GJ,Ong C,Mui AL,Chung SW

更新日期：2002-04-01 00:00:00

abstract：:Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are ...

journal_title：Immunology letters

authors： Stefani MM,Takehara HA,Mota I

更新日期：1983-01-01 00:00:00

abstract：:The possibility of inducing immune responses to murine interleukin-4 (IL-4) and IL-13 and generating anti-cytokine monoclonal antibodies (mAbs) was studied in IL-4- and IL-13-knockout mice. The minimal doses of IL-4 or IL-13 that could induce significant anti-cytokine responses with titers of 5000-10,000 were 20 micro...

journal_title：Immunology letters

authors： Shichkin VP,Spivak NY

更新日期：2006-02-15 00:00:00

abstract：:Cell surface molecules are present on several lymphocyte subsets and are differentially expressed during lymphocyte development and activation. Human Leukocyte Differentiation Antigen (HLDA) Workshops have played an essential role in the identification and characterization of the molecules found in the membrane of hem...

journal_title：Immunology letters

authors： Llinàs L,Lázaro A,de Salort J,Matesanz-Isabel J,Sintes J,Engel P

更新日期：2011-01-30 00:00:00

abstract：:Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune activation, which lim...

journal_title：Immunology letters

authors： Maroni D,Rana S,Mukhopadhyay C,Natarajan A,Naramura M

更新日期：2015-12-01 00:00:00

abstract：:The effect of melphalan (L-PAM; L-phenylalanine mustard) administration on natural killer (NK) and natural cytotoxic (NC) activities of spleen cells from normal noninoculated BALB/c mice and mice bearing large MOPC-315 plasmacytoma tumors was investigated. Injection of L-PAM (7.5 or 15.0 mg/kg) had no effect on NK and...

journal_title：Immunology letters

authors： Nahas F,Ophir R,Ben-Efraim S

更新日期：1985-01-01 00:00:00

abstract：:Recent data provide evidence that antigen-specific CD4+ T-cell clones or antigen-activated T-cell lines can kill antigen-presenting cells (APC). We focused our studies on monocytes acting as APC in cultures of T cells freshly isolated from peripheral blood. The presence of monocytes in culture was monitored by their a...

journal_title：Immunology letters

authors： Pryjma J,Zembala M,Baran J,Ernst M,Flad HD

更新日期：1995-06-01 00:00:00

abstract：:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...

journal_title：Immunology letters

authors： van Bohemen CG,Langenberg ML,Rauws EA,Oudbier J,Weterings E,Zanen HC

更新日期：1989-01-15 00:00:00

abstract：:In several diseases where the immune system plays an important role there has been a tremendous progress in treatment efficacy during the last decades. Based on necessary basic science these improvements are results of rapid, numerous and open-minded clinical trials where pieces of positive results step by step have b...

journal_title：Immunology letters

authors： Ludvigsson J

更新日期：2014-05-01 00:00:00

abstract：:Foxp3+ Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self. Therefore, it is expected that lower numbers and/or less than optimal function could impact on the functioning of the immune system, and thereby contributing to the development of autoimmune diseases. In the present report, by co...

journal_title：Immunology letters

authors： Godoy GJ,Paira DA,Olivera C,Breser ML,Sanchez LR,Motrich RD,Rivero VE

更新日期：2020-07-01 00:00:00

abstract：:Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice conta...

journal_title：Immunology letters

authors： Berger CN,Epstein CJ

更新日期：1992-06-01 00:00:00

abstract：:To examine whether grape seed proanthocyanidin extract (GSPE) which is known to act as an antioxidant has therapeutic effect on collagen-induced arthritis (CIA) in mice, an animal model of rheumatoid arthritis. Mice were treated with an intraperitoneal injection of GSPE (10, 50, or 100 mg/kg) or saline. Clinical, hist...

journal_title：Immunology letters

authors： Cho ML,Heo YJ,Park MK,Oh HJ,Park JS,Woo YJ,Ju JH,Park SH,Kim HY,Min JK

更新日期：2009-06-04 00:00:00

abstract：:To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted durin...

journal_title：Immunology letters

authors： Schattner A,Hanuka N,Sarov B,Bentwich Z

更新日期：1994-04-01 00:00:00

abstract：:T cell specific, B cell specific and Ia specific polyclonal antisera, as well as monoclonal antibodies, were employed to characterize cells involved in regulation of T cells, proliferating upon stimulation with concanavalin A or phytohaemagglutinin. Evidence for Ia+ accessory cells was obtained and the constellation o...

journal_title：Immunology letters

authors： Ponsard DC,Chou CT,Cinader B,Dubiski S

更新日期：1986-08-01 00:00:00

abstract：:The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) ...

journal_title：Immunology letters

authors： Gern L,Rais O,Capiau C,Hauser P,Lobet Y,Simoen E,Voet P,Pêtre J

更新日期：1994-03-01 00:00:00

abstract：:Previous studies have demonstrated that culture supernatants of LPS-stimulated murine splenic B lymphocytes (BLPSSN) are able to inhibit the growth of freshly isolated B cells via an IgM antibody. In this work we investigated the progress of LPS-activated B lymphocytes through the cell cycle in the presence of this an...

journal_title：Immunology letters

authors： Uher F,Mihalik R,Alonso ME,Gergely J

更新日期：1992-08-01 00:00:00