Abstract：
:Naive CD4 T cell activation is a complex process involving many steps. T cell receptor (TCR) signals, provided by interaction with peptide/MHC on antigen-presenting cells (APC), control many events associated with activation. The extent of TCR signaling and the magnitude of the T cell response is in turn controlled by accessory molecules on APC, which stabilize T-APC interactions. Full T cell activation additionally requires multiple costimulatory signals, generated upon ligation of T cell coreceptors by accessory molecules, and these lead to IL-2 production, proliferation and differentiation of the naive cell into an effector state. This review summarizes the role played by accessory molecules in naive CD4 activation and discusses how integration of signals from these molecules, with signals from the TCR, may determine the outcome of T-APC interaction. The available data provide explanations for why only APC which express high levels of multiple costimulatory/adhesion molecules, such as dendritic cells and activated B cells, induce efficient naive T cell responses, and suggest that ICAM-1/LFA-1 and B7/CD28 interactions are major pathways used to initiate naive T cell activation.
journal_name
Immunol Resjournal_title
Immunologic researchauthors
Dubey C,Croft Mdoi
10.1007/BF02918501subject
Has Abstractpub_date
1996-01-01 00:00:00pages
114-25issue
2eissn
0257-277Xissn
1559-0755journal_volume
15pub_type
杂志文章,评审abstract：:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadl...
journal_title：Immunologic research
pub_type： 杂志文章,评审
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：1999-01-01 00:00:00
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journal_title：Immunologic research
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更新日期：2014-01-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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更新日期：1996-01-01 00:00:00
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更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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更新日期：2007-01-01 00:00:00
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更新日期：2011-04-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2017-08-01 00:00:00
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更新日期：2016-12-01 00:00:00
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更新日期：2020-02-01 00:00:00
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journal_title：Immunologic research
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
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更新日期：2015-05-01 00:00:00
