Is there an association between alopecia areata and systemic lupus erythematosus? A population-based study.

abstract：:LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...

journal_title：Immunologic research

authors： Jongstra-Bilen J,Jongstra J

更新日期：2006-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a chronic autoimmune disease in which β cells are destroyed. Islet transplantation is the most promising therapeutic treatment for T1D patients. However, allograft rejection and autoimmune reaction have been recognized as primary causes of graft loss after transplantation. Alpha-1-antitrypsin ...

journal_title：Immunologic research

authors： Yang L,Liao YT,Yang XF,Reng LW,Qi H,Li FR

更新日期：2015-05-01 00:00:00

abstract：:Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to cortico...

journal_title：Immunologic research

authors： Rojas CM,Borella E,Palma L,Ragozzino S,De Ramón E,Gomez-Huelgas R,Punzi L,Doria A

更新日期：2015-02-01 00:00:00

abstract：:Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, tempora...

journal_title：Immunologic research

authors： Rudy GB,Sutherland RM,Lew AM

更新日期：1997-01-01 00:00:00

abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

journal_title：Immunologic research

authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

更新日期：2017-08-01 00:00:00

abstract：:Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracel...

journal_title：Immunologic research

authors： Lu Y,Durkin JP

更新日期：1997-01-01 00:00:00

abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...

journal_title：Immunologic research

authors： Fu C,Jiang A

更新日期：2010-03-01 00:00:00

abstract：:Invariant CD1d-restricted natural killer T (iNKT) cells function during innate and adaptive immune responses. A functional and numerical deficiency of iNKT cells is well documented in both nonobese diabetic (NOD) mice and humans with autoimmune type 1 diabetes (T1D). Restoring the numerical and/or functional deficienc...

journal_title：Immunologic research

authors： Hussain S,Wagner M,Ly D,Delovitch TL

更新日期：2005-01-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T-B+NK-) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mu...

journal_title：Immunologic research

authors： Khanolkar A,Wilks JD,Liu G,Simpson BM,Caparelli EA,Kirschmann DA,Bergerson J,Fuleihan RL

更新日期：2020-02-01 00:00:00

abstract：:Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increase...

journal_title：Immunologic research

authors： Draskovic-Pavlovic B,Vucevic D,Bozic B,Majstorovic I,Colic M

更新日期：2012-04-01 00:00:00

abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...

journal_title：Immunologic research

authors： Sharma R,Das A

更新日期：2018-02-01 00:00:00

abstract：:Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...

journal_title：Immunologic research

authors： Chaudhari BR,Murphy RF,Agrawal DK

更新日期：2006-01-01 00:00:00

abstract：:Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune responses. On the other hand, such an inverse correlation has also been evidenced between allergies and bacterial infections, associated to Th1 responses. In th...

journal_title：Immunologic research

authors： Roumier T,Capron M,Dombrowicz D,Faveeuw C

更新日期：2008-01-01 00:00:00

abstract：:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadl...

journal_title：Immunologic research

authors： Segal Y,Blank M,Shoenfeld Y

更新日期：2018-12-01 00:00:00

abstract：:The examination of the immune T cell response to herpes simplex virus (HSV) antigen glycoprotein D (gD) in an ongoing infection has revealed a uniquely broad range of antigenic determinants seen. This has been shown in the murine T cell response to gD determinants where over 60% of the overlapping peptides are recogni...

journal_title：Immunologic research

authors： Heber-Katz E

更新日期：1998-01-01 00:00:00

abstract：:Naive CD4 T cell activation is a complex process involving many steps. T cell receptor (TCR) signals, provided by interaction with peptide/MHC on antigen-presenting cells (APC), control many events associated with activation. The extent of TCR signaling and the magnitude of the T cell response is in turn controlled by...

journal_title：Immunologic research

authors： Dubey C,Croft M

更新日期：1996-01-01 00:00:00

abstract：:In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...

journal_title：Immunologic research

authors： Bizzaro N,Tozzoli R,Villalta D

更新日期：2015-02-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...

journal_title：Immunologic research

authors： Zhang P,Chen BJ,Chao NJ

更新日期：2011-04-01 00:00:00

abstract：:This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-o...

journal_title：Immunologic research

authors： Scavuzzi BM,Simão ANC,Iriyoda TMV,Lozovoy MAB,Stadtlober NP,Franchi Santos LFDR,Flauzino T,de Medeiros FA,de Sá MC,Consentin L,Reiche EMV,Maes M,Dichi I

更新日期：2018-02-01 00:00:00

abstract：:In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm...

journal_title：Immunologic research

authors： Tsur A,Hughes GC,Shoenfeld Y,Carp H

更新日期：2015-02-01 00:00:00

abstract：:CD23, also known as the low affinity receptor for IgE (Fc epsilon RII), belongs to a novel superfamily of type-II integral membrane proteins. Fc epsilon RII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by severa...

journal_title：Immunologic research

authors： Sarfati M,Fournier S,Wu CY,Delespesse G

更新日期：1992-01-01 00:00:00

abstract：:WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...

journal_title：Immunologic research

authors： Ramesh N,Geha R

更新日期：2009-01-01 00:00:00

abstract：:Activation-induced cell death (AICD) has been demonstrated in T-cell hybridomas, immature thymocytes, and activated mature T cells. However, the molecular mechanisms of AICD and its physiological role in T-helper-cell differentiation remain uncertain. Recently, we have shown that Th1 and Th2 cells have distinct mechan...

journal_title：Immunologic research

authors： Roberts AI,Devadas S,Zhang X,Zhang L,Keegan A,Greeneltch K,Solomon J,Wei L,Das J,Sun E,Liu C,Yuan Z,Zhou JN,Shi Y

更新日期：2003-01-01 00:00:00

abstract：:An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it is the immune response that may also contribute to the developme...

journal_title：Immunologic research

authors： Liu MT,Lane TE

更新日期：2001-01-01 00:00:00

abstract：:The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclero...

journal_title：Immunologic research

authors： Barnum SR

更新日期：2002-01-01 00:00:00

abstract：:Mutations of the Wiskott-Aldrich Syndrome Protein (WASP) are responsible for classic Wiskott-Aldrich Syndrome (WAS), X-linked thrombocytopenia (XLT), and in rare instances congenital X-linked neutropenia (XLN). WASP is a regulator of actin polymerization in hematopoietic cells with well-defined functional domains that...

journal_title：Immunologic research

authors： Ochs HD

更新日期：2009-01-01 00:00:00

abstract：:About one half of circulating human B cells express the Leu-8 peripheral lymph node homing receptor that has been implicated in adhesion of lymphocytes and neutrophils to vascular endothelium. A novel and unique function of the Leu-8 antigen has been found in the present study: anti-Leu-8 monoclonal antibody directly ...

journal_title：Immunologic research

authors： Murakawa Y,Strober W,James SP

更新日期：1991-01-01 00:00:00

abstract：:The erbB family of receptor tyrosine kinases are growth factor receptors that are overexpressed or mutated in a large variety of human cancers. Studies of erbB-mediated signal transduction will lead to an understanding of the role played by this family of receptors in normal and transformed cells. In this article, we ...

journal_title：Immunologic research

authors： O'Rourke DM,Greene MI

更新日期：1998-01-01 00:00:00

abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...

journal_title：Immunologic research

authors： Modell V,Orange JS,Quinn J,Modell F

更新日期：2018-06-01 00:00:00